論文

査読有り
2007年1月

Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization

HISTOLOGY AND HISTOPATHOLOGY
  • H. Kondoh
  • ,
  • M. E. Lleonart
  • ,
  • D. Bernard
  • ,
  • J. Gil

22
1
開始ページ
85
終了ページ
90
記述言語
英語
掲載種別
出版者・発行元
F HERNANDEZ

Reactive oxygen species (ROS) play a crucial role not only in the physiological signal transduction but also in the pathogenesis of several human diseases such as atherosclerosis, neurodegenerative diseases, metabolic disorders, aging or cancer amongst others. Oxidative stress is also responsible for cellular and organism senescence, in accordance with what Harman initially proposed in the free radical theory of aging. Recent findings support the notion that protection from oxidative stress can increase life span significantly. We reported that enhanced glycolysis could modulate cellular life span with reduction of oxidative stress. Moreover, the tumor suppressor gene p53 controls post-transcriptionally the level of the glycolytic enzyme, phosphoglycerate mutase (PGM). As enhanced glycolysis is a distinctive and prominent feature of cancer cells (termed the Warburg effect), our findings disclosed a novel aspect of the Warburg effect: the connection between senescence and oxidative stress.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000242576500010&DestApp=WOS_CPL
ID情報
  • ISSN : 0213-3911
  • eISSN : 1699-5848
  • Web of Science ID : WOS:000242576500010

エクスポート
BibTeX RIS