論文

2021年9月14日

Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites

Proceedings of the National Academy of Sciences
  • Takayuki Teruya
  • ,
  • Yung-Ju Chen
  • ,
  • Hiroshi Kondoh
  • ,
  • Yasuhide Fukuji
  • ,
  • Mitsuhiro Yanagida

118
37
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.2022857118
出版者・発行元
Proceedings of the National Academy of Sciences

Significance

Dementia is a slowly progressing, chronic, and usually irreversible decline in cognitive function. Mechanistic causes and definitive treatments remain elusive. Using comprehensive metabolomics, we identified five groups of 33 metabolites (A to E), 13 of them previously reported, possibly useful for diagnosis and therapy of forms of dementia, such as Alzheimer’s disease. Seven A compounds may act as neurotoxins, whereas B to E compounds may protect the nervous system against oxidative stress, maintain energy reserves, supply nutrients and neuroprotective factors. Five metabolites, ergothioneine, S -methyl-ergothioneine, trimethyl-histidine, methionine, and tryptophan, overlap with those reported for frailty. Interventions for cognitive diseases involving these dementia metabolomic markers may be accomplished either by inhibiting A compounds or by supplementing B to E compounds in patients.

リンク情報
DOI
https://doi.org/10.1073/pnas.2022857118
URL
http://www.pnas.org/syndication/doi/10.1073/pnas.2022857118
URL
https://pnas.org/doi/pdf/10.1073/pnas.2022857118
ID情報
  • DOI : 10.1073/pnas.2022857118
  • ISSN : 0027-8424
  • eISSN : 1091-6490

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