2012年8月
The protein kinase MLTK regulates chondrogenesis by inducing the transcription factor Sox6
DEVELOPMENT
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- ,
- ,
- 巻
- 139
- 号
- 16
- 開始ページ
- 2988
- 終了ページ
- 2998
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1242/dev.078675
- 出版者・発行元
- COMPANY OF BIOLOGISTS LTD
Sox9 acts together with Sox5 or Sox6 as a master regulator for chondrogenesis; however, the inter-relationship among these transcription factors remains unclear. Here, we show that the protein kinase MLTK plays an essential role in the onset of chondrogenesis through triggering the induction of Sox6 expression by Sox9. We find that knockdown of MLTK in Xenopus embryos results in drastic loss of craniofacial cartilages without defects in neural crest development. We also find that Sox6 is specifically induced during the onset of chondrogenesis, and that the Sox6 induction is inhibited by MLTK knockdown. Remarkably, Sox6 knockdown phenocopies MLTK knockdown. Moreover, we find that ectopic expression of MLTK induces Sox6 expression in a Sox9-dependent manner. Our data suggest that p38 and JNK pathways function downstream of MLTK during chondrogenesis. These results identify MLTK as a novel key regulator of chondrogenesis, and reveal its action mechanism in chondrocyte differentiation during embryonic development.
- リンク情報
- ID情報
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- DOI : 10.1242/dev.078675
- ISSN : 0950-1991
- PubMed ID : 22764049
- Web of Science ID : WOS:000306706300016