渡邉智裕 (Tomohiro Watanabe) - マイポータル

基本情報

所属: 近畿大学医学部内科学教室 (消化器内科部門）准教授

学位: 博士（医学）(京都大学)

研究者番号: 40444468
J-GLOBAL ID: 201401067043016852

研究キーワード

研究分野

経歴

もっとみる

学歴

1998年 - 2002年

京都大学大学院医学研究科内科系専攻
1987年 - 1993年

京都大学医学部医学科

委員歴

2020年1月 - 現在

日本消化器病学会学会評議員
2019年11月 - 現在

第２７回若手膵臓研究会当番世話人
2019年8月 - 現在

医療系大学間共用試験実施評価機構医学系CBT実施小委員会ブラッシュアップ専門部会委員
2019年5月 - 現在

Society for Mucosal Immunology International Congress of Mucosal Immunology 査読委員
2019年 - 現在

近畿大学医学部 OSCE委員

もっとみる

受賞

もっとみる

論文

241

ATG16L1 negatively regulates RICK/RIP2-mediated innate immune responses

Hajime Honjo, Tomohiro Watanabe, Yasuyuki Arai, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Kouhei Yamashita, Masatoshi Kudo

International Immunology 2020年9月10日査読有り
Gut microbiome alterations in type 1 autoimmune pancreatitis after induction of remission by prednisolone

Ken Kamata, Tomohiro Watanabe, Kosuke Minaga, Akane Hara, Ikue Sekai, Yasuo Otsuka, Tomoe Yoshikawa, Ah‐Mee Park, Masatoshi Kudo

Clinical & Experimental Immunology 2020年9月2日査読有り
Identification of serum IFN-α and IL-33 as novel biomarkers for type 1 autoimmune pancreatitis and IgG4-related disease

Kosuke Minaga, Tomohiro Watanabe, Akane Hara, Ken Kamata, Shunsuke Omoto, Atsushi Nakai, Yasuo Otsuka, Ikue Sekai, Tomoe Yoshikawa, Kentaro Yamao, Mamoru Takenaka, Yasutaka Chiba, Masatoshi Kudo

Scientific Reports 10(1) 2020年9月査読有り
Diffuse Pancreas Swelling in a Patient with Multiple Myeloma

Akane Hara, Kosuke Minaga, Tomohiro Watanabe

Gastroenterology 2020年6月査読有り
Recurrent abdominal pain caused by nephroptosis.

Saki Yoshida, Mariko Matsumura, Kiyoshi Maekawa, Kosuke Minaga, Ken Kamata, Masahiro Nozawa, Tomohiro Watanabe, Masatoshi Kudo

Clinical journal of gastroenterology 13(4) 621 - 625 2020年2月28日査読有り
Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis.

Kosuke Minaga, Tomohiro Watanabe, Yasuyuki Arai, Masahiro Shiokawa, Akane Hara, Tomoe Yoshikawa, Ken Kamata, Kouhei Yamashita, Masatoshi Kudo

Journal of gastroenterology 55(5) 565 - 576 2020年1月20日査読有り
Possible involvement of autophagy in esophageal ulcers in anorexia nervosa.

Sho Masaki, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Yoriaki Komeda, Masatomo Kimura, Masatoshi Kudo

Clinical journal of gastroenterology 13(4) 473 - 476 2020年1月3日査読有り
Intestinal dysbiosis mediates experimental autoimmune pancreatitis via activation of plasmacytoid dendritic cells.

Ken Kamata, Tomohiro Watanabe, Kosuke Minaga, Akane Hara, Tomoe Yoshikawa, Ayana Okamoto, Kentaro Yamao, Mamoru Takenaka, Ah-Mee Park, Masatoshi Kudo

International immunology 31(12) 795 - 809 2019年11月8日査読有り
RICK/RIP2 is a NOD2-independent nodal point of gut inflammation

Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Toshiharu Sakurai, Yoriaki Komeda, Tomoyuki Nagai, Atsushi Kitani, Masaki Tajima, Ivan J Fuss, Masatoshi Kudo, Warren Strober

International Immunology 31(10) 669 - 683 2019年9月18日査読有り
Hepatic portal venous gas associated with Klebsiella oxytoca infection in the absence of preceding antibiotic treatment

Hidekazu Tanaka, Tomohiro Watanabe, Tomoyuki Nagai, Kosuke Minaga, Ken Kamata, Yoriaki Komeda, Masatoshi Kudo

Clinical Journal of Gastroenterology 12(4) 316 - 319 2019年8月査読有り
The IFN-α-IL-33 Axis as Possible Biomarkers in IgG4-Related Disease

Kosuke Minaga, Tomohiro Watanabe, Ken Kamata, Mamoru Takenaka, Satoru Yasukawa, Masatoshi Kudo

The American Journal of Gastroenterology 114(6) 1002 - 1003 2019年6月査読有り
Recent Updates on the Relationship between Cancer and Autoimmune Pancreatitis

Ayana Okamoto, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo

Internal Medicine 58(11) 1533 - 1539 2019年6月1日査読有り
Autoimmune hepatitis and IgG4-related disease

Kosuke Minaga, Tomohiro Watanabe, Hobyung Chung, Masatoshi Kudo

World Journal of Gastroenterology 25(19) 2308 - 2314 2019年5月21日査読有り
Cytokines produced by innate immune cells in IgG4-related disease

Tomoe Yoshikawa, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Masatoshi Kudo

Modern Rheumatology 29(2) 219 - 225 2019年3月4日査読有り
Mechanistic Insights into Autoimmune Pancreatitis and IgG4-Related Disease

Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Masatoshi Kudo, Warren Strober

Trends in Immunology 39(11) 874 - 889 2018年11月査読有り
Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice.

Yojiro Sakuma, Yuzo Kodama, Takaaki Eguchi, Norimitsu Uza, Yoshihisa Tsuji, Masahiro Shiokawa, Takahisa Maruno, Katsutoshi Kuriyama, Yoshihiro Nishikawa, Yuki Yamauchi, Motoyuki Tsuda, Tatsuki Ueda, Tomoaki Matsumori, Toshihiro Morita, Teruko Tomono, Nobuyuki Kakiuchi, Atsushi Mima, Yuko Sogabe, Saiko Marui, Takeshi Kuwada, Akihiko Okada, Tomohiro Watanabe, Hiroshi Nakase, Tsutomu Chiba, Hiroshi Seno

Scientific reports 8(1) 8829 - 8829 2018年6月11日査読有り
Dysbiosis-Associated Polyposis of the Colon—Cap Polyposis

Kazuki Okamoto, Tomohiro Watanabe, Yoriaki Komeda, Ayana Okamoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Satoru Hagiwara, Toshiharu Sakurai, Tomonori Tanaka, Hiroki Sakamoto, Kiyoshige Fujimoto, Naoshi Nishida, Masatoshi Kudo

Frontiers in Immunology 9 2018年5月7日査読有り
Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review

Kosuke Minaga, Tomohiro Watanabe, Ken Kamata, Naoki Asano, Masatoshi Kudo

World Journal of Gastroenterology 24(16) 1725 - 1733 2018年4月28日査読有り
Induction of Complete Remission by Azacitidine in a Patient with Myelodysplastic Syndrome-Associated Inflammatory Bowel Disease

Masashi Kono, Yoriaki Komeda, Toshiharu Sakurai, Ayana Okamoto, Kosuke Minaga, Ken Kamata, Satoru Hagiwara, Hiroaki Inoue, Eisuke Enoki, Itaru Matsumura, Tomohiro Watanabe, Masatoshi Kudo

Journal of Crohn's and Colitis 12(4) 499 - 502 2018年3月28日査読有り
Autoimmune Pancreatitis Mouse Model

Ken Kamata, Tomohiro Watanabe, Kosuke Minaga, Warren Strober, Masatoshi Kudo

Current Protocols in Immunology 120(1) 2018年1月査読有り
Chronic Fibro-Inflammatory Responses in Autoimmune Pancreatitis Depend on IFN-α and IL-33 Produced by Plasmacytoid Dendritic Cells

Tomohiro Watanabe, Kouhei Yamashita, Yasuyuki Arai, Kosuke Minaga, Ken Kamata, Tomoyuki Nagai, Yoriaki Komeda, Mamoru Takenaka, Satoru Hagiwara, Hiroshi Ida, Toshiharu Sakurai, Naoshi Nishida, Warren Strober, Masatoshi Kudo

The Journal of Immunology 198(10) 3886 - 3896 2017年5月15日査読有り
Immunopathogenesis of pancreatitis

T. Watanabe, M. Kudo, W. Strober

Mucosal Immunology 10(2) 283 - 298 2017年3月1日査読有り
IgG4-Related Disease and Innate Immunity

Tomohiro Watanabe, Kouhei Yamashita, Masatoshi Kudo

IGG4-RELATED DISEASE 401 115 - 128 2017年査読有り招待有り
Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders

Tomohiro Watanabe, Naoki Asano, Masatoshi Kudo, Warren Strober

Proceedings of the Japan Academy Series B: Physical and Biological Sciences 93(8) 578 - 599 2017年査読有り
Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis

T. Watanabe, Y. Sadakane, N. Yagama, T. Sakurai, H. Ezoe, M. Kudo, T. Chiba, W. Strober

MUCOSAL IMMUNOLOGY 9(5) 1234 - 1249 2016年9月査読有り
Pathogenicity of IgG in patients with IgG4-related disease

Masahiro Shiokawa, Yuzo Kodama, Katsutoshi Kuriyama, Kenichi Yoshimura, Teruko Tomono, Toshihiro Morita, Nobuyuki Kakiuchi, Tomoaki Matsumori, Atsushi Mima, Yoshihiro Nishikawa, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Ryuki Minami, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Akira Kurita, Yugo Sawai, Yoshihisa Tsuji, Norimitsu Uza, Kazuyoshi Matsumura, Tomohiro Watanabe, Kenji Notohara, Tatsuaki Tsuruyama, Hiroshi Seno, Tsutomu Chiba

GUT 65(8) 1322 - 1332 2016年8月査読有り
Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses

Naoki Asano, Akira Imatani, Tomohiro Watanabe, Jun Fushiya, Yutaka Kondo, Xiaoyi Jin, Nobuyuki Ara, Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Warren Strober, Tooru Shimosegawa

CANCER RESEARCH 76(5) 1135 - 1145 2016年3月査読有り
Plasmacytoid Dendritic Cell Activation and IFN-α Production Are Prominent Features of Murine Autoimmune Pancreatitis and Human IgG4-Related Autoimmune Pancreatitis

Yasuyuki Arai, Kouhei Yamashita, Katsutoshi Kuriyama, Masahiro Shiokawa, Yuzo Kodama, Toshiharu Sakurai, Kiyomi Mizugishi, Kazushige Uchida, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Masatoshi Kudo, Kazuichi Okazaki, Warren Strober, Tsutomu Chiba, Tomohiro Watanabe

The Journal of Immunology 195(7) 3033 - 3044 2015年10月1日査読有り
NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6

T. Watanabe, N. Asano, G. Meng, K. Yamashita, Y. Arai, T. Sakurai, M. Kudo, I. J. Fuss, A. Kitani, T. Shimosegawa, T. Chiba, W. Strober

Mucosal Immunology 7(6) 1312 - 1325 2014年11月25日査読有り
Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease

Warren Strober, Naoki Asano, Ivan Fuss, Atsushi Kitani, Tomohiro Watanabe

Immunological Reviews 260(1) 249 - 260 2014年7月査読有り招待有り
Risk of Cancer in Patients With Autoimmune Pancreatitis

Masahiro Shiokawa, Yuzo Kodama, Kenichi Yoshimura, Chiharu Kawanami, Jun Mimura, Yukitaka Yamashita, Masanori Asada, Masataka Kikuyama, Yoshihiro Okabe, Tetsuro Inokuma, Masaya Ohana, Hiroyuki Kokuryu, Kazuo Takeda, Yoshihisa Tsuji, Ryuki Minami, Yojiro Sakuma, Katsutoshi Kuriyama, Yuji Ota, Wataru Tanabe, Takahisa Maruno, Akira Kurita, Yugo Sawai, Norimitsu Uza, Tomohiro Watanabe, Hironori Haga, Tsutomu Chiba

AMERICAN JOURNAL OF GASTROENTEROLOGY 108(4) 610 - 617 2013年4月査読有り
Toll-like receptor activation in basophils contributes to the development of IgG4-related disease

Tomohiro Watanabe, Kouhei Yamashita, Toshiharu Sakurai, Masatoshi Kudo, Masahiro Shiokawa, Norimitsu Uza, Yuzo Kodama, Kazushige Uchida, Kazuichi Okazaki, Tsutomu Chiba

Journal of Gastroenterology 48(2) 247 - 253 2013年2月査読有り
Sensing of commensal organisms by the intracellular sensor nod1 mediates experimental pancreatitis

Yoshihisa Tsuji, Tomohiro Watanabe, Masatoshi Kudo, Hidenori Arai, Warren Strober, Tsutomu Chiba

Immunity 37(2) 326 - 338 2012年8月24日査読有り
Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation

A. Takai, H. Marusawa, Y. Minaki, T. Watanabe, H. Nakase, K. Kinoshita, G. Tsujimoto, T. Chiba

Oncogene 31(13) 1733 - 1742 2012年3月29日査読有り
Involvement of activation of toll-like receptors and nucleotide-binding oligomerization domain-like receptors in enhanced IgG4 responses in autoimmune pancreatitis

Tomohiro Watanabe, Kouhei Yamashita, Saori Fujikawa, Toshiharu Sakurai, Masatoshi Kudo, Masahiro Shiokawa, Yuzo Kodama, Kazushige Uchida, Kazuichi Okazaki, Tsutomu Chiba

ARTHRITIS AND RHEUMATISM 64(3) 914 - 924 2012年3月査読有り
Correlation between hyporesponsiveness to Toll-like receptor ligands and liver dysfunction in patients with chronic hepatitis C virus infection

H. Chung, T. Watanabe, M. Kudo, T. Chiba

JOURNAL OF VIRAL HEPATITIS 18(10) E561 - E567 2011年10月査読有り
NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

W. Strober, T. Watanabe

Mucosal Immunology 4(5) 484 - 495 2011年9月査読有り招待有り
Activation of type I IFN signaling by NOD1 mediates mucosal host defense againstHelicobacter pyloriinfection

Tomohiro Watanabe, Naoki Asano, Atsushi Kitani, Ivan J. Fuss, Tsutomu Chiba, Warren Strober

Gut Microbes 2(1) 61 - 65 2011年1月査読有り
Card15 Polymorphisms in the Immunopathogenesis of Crohn's Disease and Mycobacterial Infectious Diseases

Tomohiro Watanabe, Tsutomu Chiba

Gastroenterology 139(6) 2212 - 2214 2010年12月査読有り
Hepatitis C Virus Core Protein Induces Homotolerance and Cross-Tolerance to Toll-Like Receptor Ligands by Activation of Toll-Like Receptor 2

Hobyung Chung, Tomohiro Watanabe, Masatoshi Kudo, Tsutomu Chiba

JOURNAL OF INFECTIOUS DISEASES 202(6) 853 - 861 2010年9月査読有り
Enhanced cytokine responses to Toll-like and NOD-like receptor ligands in primary biliary cirrhosis-CREST overlap syndrome

Manabu Fukuhara, Tomohiro Watanabe, Taro Ueo, Hiroshi Ida, Yuzo Kodama, Tsutomu Chiba

RHEUMATOLOGY 49(8) 1602 - 1604 2010年8月査読有り
NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

Tomohiro Watanabe, Naoki Asano, Stefan Fichtner-Feigl, Peter L. Gorelick, Yoshihisa Tsuji, Yuko Matsumoto, Tsutomu Chiba, Ivan J. Fuss, Atsushi Kitani, Warren Strober

Journal of Clinical Investigation 120(5) 1645 - 1662 2010年5月3日査読有り
Defective Interleukin-10 Signaling in Human Inflammatory Bowel Disease

Tomohiro Watanabe, Tsutomu Chiba

Gastroenterology 138(5) 2016 - 2018 2010年5月査読有り
Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease

Reiko Akitake, Tomohiro Watanabe, Chikage Zaima, Norimitsu Uza, Hiroshi Ida, Shinsuke Tada, Naoshi Nishida, Tsutomu Chiba

GUT 59(4) 542 - 545 2010年4月査読有り
Identification and characterization of IgG4-associated autoimmune hepatitis

Hobyung Chung, Tomohiro Watanabe, Masatoshi Kudo, Osamu Maenishi, Yoshio Wakatsuki, Tsutomu Chiba

LIVER INTERNATIONAL 30(2) 222 - 231 2010年2月査読有り
Colonic Polyposis Associated With Autoimmune Pancreatitis

Hiroyuki Matsui, Tomohiro Watanabe, Kenji Ueno, Satoru Ueno, Yoshihisa Tsuji, Kayoko Matsumura, Masato Nakatsuji, Yoshihide Ueda, Tsutomu Chiba

PANCREAS 38(7) 840 - 842 2009年10月査読有り
Massive jejunal bleeding due to Heyde syndrome successfully treated with double balloon endoscopy.

Sakiko Ohta, Tomohiro Watanabe, Shuko Morita, Satoru Ueno, Yoshihisa Tsuji, Hiroshi Nakase, Tsutomu Chiba

Clinical journal of gastroenterology 2(3) 187 - 189 2009年6月査読有り
Simultaneous Occurrence of Inflammatory Bowel Disease and Myelodysplastic Syndrome due to Chromosomal Abnormalities in Bone Marrow Cells

Fumiyasu Nakamura, Tomohiro Watanabe, Kimiko Hori, Yoshiaki Ohara, Kouhei Yamashita, Yoshihisa Tsuji, Yoshihide Ueda, Sakae Mikami, Hiroshi Nakase, Tsutomu Chiba

DIGESTION 79(4) 215 - 219 2009年査読有り
IgG4-related autoimmune pancreatitis involving the colonic mucosa

Kenji Ueno, Tomohiro Watanabe, Yukiko Kawata, Tomoyuki Gotoh, Yoshihisa Tsuji, Hiroshi Ida, Shinsuke Tada, Shujiro Yazumi, Tsutomu Chiba

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 20(11) 1118 - 1121 2008年11月査読有り
The molecular basis of NOD2 susceptibility mutations in Crohn's disease

W. Strober, A. Kitani, I. Fuss, N. Asano, T. Watanabe

MUCOSAL IMMUNOLOGY 1(Suppl 1) S5 - S9 2008年11月査読有り招待有り

もっとみる

MISC

PPI長期投与の有無からみた胃底腺ポリープの臨床病理学的検討

松村まり子, 辻直子, 梅原康湖, 正木翔, 岡元寿樹, 山田光成, 永井知行, 米田頼晃, 櫻井俊治, 松井繁長, 渡邉智裕, 樫田博史, 工藤正俊

日本消化器病学会雑誌 116(臨増大会) A755 - A755 2019年11月
血清IFN-α/IL-33が治療効果判定に有用と考えられた自己免疫性膵炎/IgG4関連疾患の1例

原茜, 三長孝輔, 岡本彩那, 石川嶺, 山崎友裕, 中井敦史, 大本俊介, 鎌田研, 山雄健太郎, 竹中完, 渡邉智裕, 安川覚, 工藤正俊

日本消化器病学会近畿支部例会プログラム・抄録集 111回 78 - 78 2019年10月
DLBCLに発症したリンパ管拡張症に対してステロイド投与、食事療法が奏効した1症例

大塚康生, 米田頼晃, 正木翔, 筑後孝章, 吉川馨介, 高島耕太, 橋本有人, 山田光成, 本庶元, 永井知行, 櫻井俊治, 松井繁長, 渡邉智裕, 辻直子, 樫田博史, 工藤正俊

日本消化器病学会近畿支部例会プログラム・抄録集 111回 91 - 91 2019年10月
血清IFN-α/IL-33が治療効果判定に有用と考えられた自己免疫性膵炎/IgG4関連疾患の1例

原茜, 三長孝輔, 岡本彩那, 石川嶺, 山崎友裕, 中井敦史, 大本俊介, 鎌田研, 山雄健太郎, 竹中完, 渡邉智裕, 安川覚, 工藤正俊

日本消化器病学会近畿支部例会プログラム・抄録集 111回 78 - 78 2019年10月
微小膵癌診断の新たなアプローチ法―3D CTによる膵実質萎縮評価から見えてきたもの―

山雄健太郎, 竹中完, 吉川智恵, 石川嶺, 岡本彩那, 中井敦, 山崎友宏, 大本俊介, 鎌田研, 三長孝輔, 松本逸平, 竹山宜典, 鶴崎正勝, 渡邉智裕, 工藤正俊

膵臓(Web) 34(3) A33‐A34(J‐STAGE) 2019年6月18日

もっとみる

書籍等出版物

展望小林がん学術振興会

渡邉智裕(担当:分担執筆, 範囲:自然免疫反応の制御を用いた膵臓癌の予防法の開発)

2018年11月
消化器内科診察レジデントマニュアル

渡邉智裕(担当:共著)

医学書院 2018年
腸内細菌叢からみた膵臓疾患の発症機序の解明と新規治療法の開発

渡邉智裕(担当:分担執筆)

ヤクルトバイオサイエンス研究財団年報第26号 2018年
ESMO HandBook Immuno-Oncology 2018

Harding JJ, Watanabe T, El-Dika I, Nishida N, Abou-alfa GK, Kudo M(担当:共著, 範囲:2.5 GI Malignancies, 2.5.3 HCC)

2018年
腸内細菌叢からみた膵炎の発症機序の解明と新規治療法の開発

渡邉智裕(担当:分担執筆)

先進医薬研究振興財団 2017年度研究成果報告集 2018年