Tomohiro Watanabe

Last updated: Mar 28, 2019 at 22:55

Name	Tomohiro Watanabe
Affiliation	Kindai University
Section	Faculty of Medicine

Research Areas

Clinical internal medicine / Gastroenterology /

Published Papers

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Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection

Komeda Y, Watanabe T, Sakurai T, Kono M, Okamoto K, Nagai T, Takenaka M, Hagiwara S, Matsui S, Nishida N, Tsuji N, Kashida H, Kudo M

World J Gastroenterol 25(12) 1502-1512 Mar 2019 [Refereed]

Hepatic portal venous gas associated with Klebsiella oxytoca infection in the absence of preceding antibiotic treatment

Tanaka H, Watanabe T, Nagai T, Minaga K, Kamata K, Komeda Y, Kudo M

Clin J Gastroenterol Feb 2019 [Refereed]

Recent Updates on the Relationship between Cancer and Autoimmune Pancreatitis

Okamoto A, Watanabe T, Kamata K, Minaga K, Kudo M.

Intern Med 2019 [Refereed]

Efficacy and Safety of Chemotherapy Following Anti-PD-1 Antibody Therapy for Gastric Cancer: A Case of Sclerosing Cholangitis

Kono M, Sakurai T, Okamoto K, Masaki S, Nagai T, Komeda Y, Kamata K, Minaga K, Yamao K, Takenaka M, Watanabe T, Nishida N, Kudo M

Intern Med 2019 [Refereed]

Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer. Digestion

Sakurai T, Komeda Y, Nagai T, Kamata K, Minaga K, Yamao K, Takenaka M, Hagiwara S, Watanabe T, Nishida N, Kashida H, Nakagawa K, Kudo M

Digestion 2018 [Refereed]

Mechanistic Insights into Autoimmune Pancreatitis and IgG4-Related Disease

Tomohiro Watanabe

Trends Immunol 39(11) 874-889 2018 [Refereed][Invited]

Cytokines produced by innate immune cells in IgG4-related disease

Yoshikawa T, Watanabe T, Minaga K, Kamata K, Kudo M

Mod Rheumatol 29(2) 219-225 2019 [Refereed][Invited]

Outcomes of endoscopic biliary drainage in pancreatic cancer patients with an indwelling gastroduodenal stent: a multicenter cohort study in west Japan

Yamao K, Kitano M, Takenaka M, Minaga K, Sakurai T, Watanabe T, Kayahara T, Yoshikawa T, Yamashita Y, Asada M, Okabe Y, Hanada K, Chiba Y, Kudo M

Gastrointest Endosc 88(1) 66-75.e2 2018 [Refereed]

Sustained antiviral effects and clearance of hepatitis surface antigen after combination therapy with entecavir and pegylated interferon in chronic hepatitis B

Hagiwara S, Nishida N, Watanabe T, Ida H, Sakurai T, Ueshima K, Takita M, Komeda Y, Nishijima N, Osaki Y, Kudo M

Antivir Ther 23 513-521 2018 [Refereed]

A case of successful transluminal drainage of walled-off necrosis under contrast-enhanced harmonic endoscopic ultrasonography guidance

Minaga K, Takenaka M, Omoto S, Miyata T, Kamata K, Yamao K, Imai H, Watanabe T, Kitano M, Kudo M

J Med Ultrason 45(1) 161-165 2018 [Refereed]

Supplementation of pancreatic digestive enzymes alters the composition of intestinal microbiota in mice

Nishiyama H, Nagai T, Kudo M, Okazaki Y, Azuma Y, Watanabe T, Goto S, Ogata H, Sakurai T

Biochem Biophys Res Commun. 495(1) 273-279 2018 [Refereed]

The relationship between the use of statins and mortality, severity and pancreatic cancer in Danish patients with chronic pancreatitis

Bang U, Watanabe T, Bendtsen F

Eur J Gastroenterol Hepatol 30(3) 346-351 2018 [Refereed]

Induction of complete remission by azacitidine in a patient with myelodysplastic syndrome-associated inflammatory bowel disease

Kono M, Komeda Y, Sakurai T, Okamoto A, Minaga K, Kamata K, Hagiwara S, Inoue H, Enoki E, Matsumura I, Watanabe T, Kudo M

J Crohns Colitis 12(4) 499-502 2018 [Refereed]

Autoimmune Pancreatitis Mouse Model.

Kamata K, Watanabe T, Minaga K, Strober W, Kudo M

Curr Protoc Immunol 120(Feb 21) 15.31.1-15.31.8 2018 [Refereed][Invited]

Dysbiosis-Associated Polyposis of the Colon—Cap Polyposis

Okamoto K, Watanabe T, Komeda Y Okamoto A, Minaga K, Kamata K, Yamao K, Takenaka M, Hagiwara S, Sakurai T,Tanaka M, Sakamoto H, Fujimoto K,Kudo M

Front. Immunol 9 918-922 2018 [Refereed]

Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review

Minaga K, Watanabe T, Kamata K, Asano N, Kudo M

24(16) 1725-1733 2018 [Refereed][Invited]

Value of additional endoscopic ultrasonography for surveillance after surgical removal of intraductal papillary mucinous neoplasms.

Kamata K, Takenaka M, Minaga K, Omoto S, Miyata T, Yamao K, Imai H, Nakai A, Tanaka H, Chiba Y, Watanabe T, Sakurai T, Nishida N, Chikugo T, Matsumoto I, Takeyama Y, Kitano M, Kudo M

Dig Endosc 30(5) 659-666 2018 [Refereed]

Cystic duct antegrade stenting for cholangitis after the long-term deployment of lumen-apposing metal stents for calculous cholecystitis

Kamata K, Takenaka M, Minaga K, Nakai A, Omoto S, Miyata T, Yamao K, Imai H, Sakurai T, Watanabe T, Nishida N, Kudo M

Endosc Ultrasound 7(5) 349-350 2018 [Refereed]

Acute Pancreatitis with Disturbed Consciousness Caused by Hyperparathyroidism

Otsuka Y, Kamata K, Minaga K, Takenaka M, Watanabe T, Kudo M

Intern Med 57(21) 3075-3078 2018 [Refereed]

Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice

Sakuma Y, Kodama Y, Eguchi T, Uza N, Tsuji Y, Shiokawa M, Maruno T, Kuriyama K, Nishikawa Y, Yamauchi Y, Tsuda M, Ueda T, Matsumori T, Morita T, Tomono T, Kakiuchi N, Mima A, Sogabe Y, Marui S, Kuwada T, Okada A, Watanabe T, Nakase H, Chiba T, Seno H

Sci Rep 8(1) 8829 2018 [Refereed]

Clinical Efficacy and Safety of EUS-guided Gallbladder Drainage Replacement of Percutaneous Drainage: A Multicenter Retrospective Study.

Minaga K, Yamashita Y, Ogura T, Takenaka M, Shimokawa Y, Hisa T, Itonaga M, Kato H, Nishikiori H, Okuda A, Matsumoto H, Uenoyama Y, Watanabe T, Chiba Y, Higuchi K, Kudo M, Kitano M

Dig Endosc 2018 [Refereed]

Erythropoietic Protoporphyria-related Hepatopathy Successfully Treated with Phlebotomy

Tomohiro Watanabe

Intern Med 57(17) 2505-2509 2018 [Refereed]

"Molecular scoring of hepatocellular carcinoma for predicting metastatic recurrence and requirements of systemic chemotherapy"

Nishida N,Nishimura T, Kaido T, Minaga K, , Yamao K, Kamata K, Takenaka M, Ida H, Hagiwara S,MinamiY, Sakurai T Watanabe T, ,Kudo M

Cancers 10 367-367 2018 [Refereed]

アミロイドーシスを疑う胃病変

松井繁長、樫田博史、河野匡司、岡元寿樹、米田頼晃、永井知行、朝隈豊、櫻井俊治、　　　　渡邉智裕、工藤正俊

消化器内視鏡 29 756-758 2017

膵炎における腸管免疫機構破綻と重症化機序

渡邉智裕、三長孝輔、鎌田研、山雄健太郎、竹中完、工藤正俊 "

肝•胆•膵 75 991-996 2017 [Invited]

パターン認識受容体

渡邉智裕、工藤正俊

消化器病学　　　サイエンス 1 150-152 2017 [Invited]

Outcome of Combination Therapy with Sofosbuvir and Ledipasvir for Chronic Type C Liver Disease

Hagiwara S, Nishida N, Watanabe T, Sakurai T, Ida H, Minami Y, Takita M, Minami T, Iwanishi M, Chishina H, Ueshima K, Komeda Y, Arizumi T, Kudo M

Oncology 92(Suppl 1) 3-9 2017

Malignant Transformation of Hepatocellular Adenoma

Kwok WY, Hagiwara S, Nishida N, Watanabe T, Sakurai T, Ida H, Minami Y, Takita M, Minami T, Iwanishi M, Chishina H, Kono M, Ueshima K, Komeda Y, Arizumi T, Enoki E, Nakai T, Kumabe T, Nakashima O, Kondo F, Kudo M

Oncology 92(Suppl 1) 16-28 2017

Unique Characteristics Associated with Sustained Liver Damage in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals

Kono M, Nishida N, Hagiwara S, Minami T, Chishina H, Arizumi T, Minaga K, Kamata K, Komeda Y, Sakurai T, Takenaka M, Takita M, Yada N, Ida H, Minami Y, Ueshima K, Watanabe T, Kudo M

Dig Dis 35(6) 556-564 2017

Impact of Tumor Factors on Survival in Patients with Hepatocellular Carcinoma Classified Based on Kinki Criteria Stage B2

Arizumi T, Minami T, Chishina H, Kono M, Takita M, Yada N, Hagiwara S, Minami Y, Ida H, Ueshima K, Kamata K, Minaga K, Komeda Y, Takenaka M, Sakurai T, Watanabe T, Nishida N, Kudo M

Dig Dis 35(6) 583-588 2017

Detection of High-Grade Pancreatic Intraepithelial Neoplasia without Morphological Changes of the Main Pancreatic Duct over a Long Period: Importance for Close Follow-Up for Confirmation

Yamao K, Takenaka M, Nakai A, Omoto S, Kamata K, Minaga K, Miyata T, Imai H, Sakurai T, Watanabe T, Nishida N, Matsumoto I, Takeyama Y, Chikugo T, Kudo M

Oncology 93(Suppl 1) 81-86 2017

Characterization of Pancreatic Tumors with Quantitative Perfusion Analysis in Contrast-Enhanced Harmonic Endoscopic Ultrasonography

Omoto S, Takenaka M, Kitano M, Miyata T, Kamata K, Minaga K, Arizumi T, Yamao K, Imai H, Sakamoto H, Harwani Y, Sakurai T, Watanabe T, Nishida N, Takeyama Y, Chiba Y, Kudo M

Oncology 93(Suppl 1) 55-60 2017

Utility of Endoscopic Ultrasound-Guided Hepaticogastrostomy with Antegrade Stenting for Malignant Biliary Obstruction after Failed Endoscopic Retrograde Cholangiopancreatography

Imai H, Takenaka M, Omoto S, Kamata K, Miyata T, Minaga K, Yamao K, Sakurai T, Nishida N, Watanabe T, Kitano M, Kudo M

Oncology 93(Suppl 1) 69-75 2017

Needle Tract Seeding: An Overlooked Rare Complication of Endoscopic Ultrasound-Guided Fine-Needle Aspiration

Minaga K, Takenaka M, Katanuma A, Kitano M, Yamashita Y, Kamata K, Yamao K, Watanabe T, Maguchi H, Kudo M

Oncology 93(Suppl 1) 107-112 2017

Primary Hepatic Adenosquamous Carcinoma Associated with Primary Sclerosing Cholangitis

Yamao K, Takenaka M, Imai H, Nakai A, Omoto S, Kamata K, Minaga K, Miyata T, Sakurai T, Watanabe T, Nishida N, Matsumoto I, Takeyama Y, Chikugo T, Kudo M

Oncology 93(Suppl 1) 76-80 2017

Computer-Aided Diagnosis Based on Convolutional Neural Network System for Colorectal Polyp Classification: Preliminary Experience

Komeda Y, Handa H, Watanabe T, Nomura T, Kitahashi M, Sakurai T, Okamoto A, Minami T, Kono M, Arizumi T, Takenaka M, Hagiwara S, Matsui S, Nishida N, KashidaH, Kudo M

Oncology 93(Suppl 1) 30-34 2017 [Refereed]

Magnifying Narrow Band Imaging (NBI) for the Diagnosis of Localized Colorectal Lesions Using the Japan NBI Expert Team (JNET) Classification

Komeda Y, Kashida H, Sakurai T, Asakuma Y, Tribonias G, Nagai T, Kono M, Minaga K, Takenaka M, Arizumi T, Hagiwara S, Matsui S, Watanabe T, Nishida N, Chikugo T, Chiba Y, Kudo M

Oncology 93(Suppl 1) 49-54 2017

Clinical Analysis of Esophageal Stricture in Patients Treated with Intralesional Triamcinolone Injection after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer

Okamoto K, Matsui S, Watanabe T, Asakuma Y, Komeda Y, Okamoto A, Rei I, Kono M, Yamada M, Nagai T, Arizumi T, Minaga K, Kamata K, Yamao K, Takenaka M, Sakurai T, Nishida N, Kashida H, Chikugo T, Kudo M

Oncology 93(Suppl 1) 9-14 2017

EUS-Guided Pancreatic Duct Drainage for Repeat Pancreatitis in a Patient with Pancreatic Cancer

Kamata K, Takenaka M, Minaga K, Sakurai T, Watanabe T, Nishida N, Kudo M

Oncology 93(Suppl 1) 87-88 2017

Time to Transcatheter Arterial Chemoembolization Refractoriness in Patients with Hepatocellular Carcinoma in Kinki Criteria Stages B1 and B2

Arizumi T, Minami T, Chishina H, Kono M, Takita M, Yada N, Hagiwara S, Minami Y, Ida H, Ueshima K, Kamata K, Minaga K, Komeda Y, Takenaka M, Sakurai T, Watanabe T, Nishida N, Kudo M

Dig Dis 35(6) 589-597 2017

Prophylactic Suturing Closure Is Recommended after Endoscopic Treatment of Colorectal Tumors in Patients with Antiplatelet/Anticoagulant Therapy

Sakurai T, Adachi T, Kono M, Arizumi T, Kamata K, Minaga K, Yamao K, Komeda Y, Takenaka M, Hagiwara S, Watanabe T, Nishida N, Kashida H, Kudo M

Oncology 93(Suppl 1) 27-29 2017

Comparative Study of Clarithromycin- versus Metronidazole-Based Triple Therapy as First-Line Eradication for Helicobacter pylori

Adachi T, Matsui S, Watanabe T, Okamoto K, Okamoto A, Kono M, Yamada M, Nagai T, Komeda Y, Minaga K, Kamata K, Yamao K, Takenaka M, Asakuma Y, Sakurai T, Nishida N, Kashida H, Kudo M

Oncology 93(Suppl 1) 15-19 2017

Clinical Significance of Bmi1 Expression in Inflammatory Bowel Disease

Yamada M, Sakurai T, Komeda Y, Nagai T, Kamata K, Minaga K, Yamao K, Takenaka M, Hagiwara S, Matsui S, Watanabe T, Nishida N, Kashida H, Kudo M

Oncology 93(Suppl 1) 20-26 2017 [Refereed]

Association between the Risk Factors for Pancreatic Ductal Adenocarcinoma and Those for Malignant Intraductal Papillary Mucinous Neoplasm

Kamata K, Takenaka M, Nakai A, Omoto S, Miyata T, Minaga K, Matsuda T, Yamao K, Imai H, Chiba Y, Sakurai T, Watanabe T, Nishida N, Chikugo T, Matsumoto I, Takeyama Y, Kudo M

Oncology 93(Suppl 1) 102-106 2017

Risk Factors for Postoperative Bleeding in Endoscopic Submucosal Dissection of Colorectal Tumors

Okamoto K, Watanabe T*, Komeda Y, Kono T, Takashima K, Okamoto A, Kono M, Yamada M, Arizumi T, Kamata K, Minaga K, Yamao K, Nagai T, Asakuma Y, Takenaka M, Sakurai T, Matsui S, Nishida N, Chikugo T, Kashida H, Kudo M

Oncology 93(Suppl 1) 35-42 2017

A case of small invasive gastric cancer arising from Helicobacter pylori-negative gastric mucosa; fundic gland type adenocarcinoma

Komeda Y, Watanabe T, Matsui S, Kashida H, Sakurai T, Kono M, Minaga K, Nagai T, Hagiwara S, Enoki E, Kuod M

JGH Open 1(2) 74-75 2017 [Refereed]

Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy

Komeda Y, Kashida H, Sakurai T, Tribonias G, Okamoto K, Kono M, Yamada M, Adachi T, Mine H, Nagai T, Asakuma Y, Hagiwara S, Matsui S, Watanabe T, Kitano M, Chikugo T, Chiba Y, Kudo M

World J Gastroenterol 23(2) 328-335 2017 [Refereed]

Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis: Long-term outcomes after removal of a self-expandable metal stent

Kamata K, Takenaka M, Kitano M, Omoto S, Miyata T, Minaga K, Yamao K, Imai H, Sakurai T, Watanabe T, Nishida N, Kudo M

World J Gastroenterol 23(4) 661-667 2017 [Refereed]

Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of submucosal tumors of the upper gastrointestinal tract

Kamata K, Takenaka M, Kitano M, Omoto S, Miyata T, Minaga K, Yamao K, Imai H, Sakurai T, Watanabe T, Nishida N, Chikugo T, Chiba Y, Imamoto H, Yasuda T, Lisotti A, Fusaroli P, Kudo M

J Gastroenterol Hepatol 32(10) 1686-1692 2017 [Refereed]

Rescue EUS-guided intrahepatic biliary drainage for malignant hilar biliary stricture after failed transpapillary re-intervention

Minaga K, Takenaka M, Kitano M, Chiba Y, Imai H, Yamao K, Kamata K, Miyata T, Omoto S, Sakurai T, Watanabe T, Nishida N, Kudo M

Surg Endosc 31(11) 4764-4772 2017 [Refereed]

A Case of Type II Enteropathy-Associated T-Cell Lymphoma in a Patient With Ulcerative Colitis

Komeda Y, Kashida H, Sakurai T, Kono M, Nagai T, Asakuma Y, Hagiwara S, Matsui S, Watanabe T, Chikugo T, Kudo M

Am J Gastroenterol 112(6) 833 2017 [Refereed]

Stress Response Protein RBM3 Promotes the Development of Colitis-associated Cancer

Sakurai T, Kashida H, Komeda Y, Nagai T, Hagiwara S, Watanabe T, Kitano M, Nishida N, Fujita J, Kudo M

Inflamm Bowel Dis 23(1) 66-74 2017 [Refereed]

The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3

Sakurai T, Higashitsuji H, Kashida H, Watanabe T, Komeda Y, Nagai T, Hagiwara S, Kitano M, Nishida N, Abe T, Kiyonari H, Itoh K, Fujita J, Kudo M

Oncotarget 8(15) 24762-24776 2017 [Refereed]

The Overall Survival of Patients with Hepatocellular Carcinoma Correlates with the Newly Defined Time to Progression after Transarterial Chemoembolization

Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Yada N, Hagiwara S, Minami Y, Ida H, Komeda Y, Takenaka M, Sakurai T, Watanabe T, Nishida N, Kudo M

Liver Cancer 6(3) 227-235 2017 [Refereed]

Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma

Sakurai T, Yada N, Hagiwara S, Arizumi T, Minaga K, Kamata K, Takenaka M, Minami Y, Watanabe T, Nishida N, Kudo M

Cancer Sci 108(10) 1996-2003 2017 [Refereed]

Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis

Hagiwara S, Nishida N, Park AM, Komeda Y, Sakurai T, Watanabe T, Kudo M

Sci Rep 7(1) 10440 2017 [Refereed]

Watanabe T, Yamashita K, Kudo M

Curr Top Microbiol Immunol 401 115-128 2017 [Refereed][Invited]

Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders

Watanabe T*, Asano N, Kudo M, Strober W

Proc Jpn Acad Ser B Phys Biol Sci 93(8) 578-599 2017 [Refereed][Invited]

Malignant Transformation of Hepatocellular Adenoma

Oncology 92(Suppl 1) 16-28 2017

Outcome of Asunaprevir/Daclatasvir Combination Therapy for Chronic Liver Disease Type C

Hagiwara S, Nishida N, Watanabe T, Sakurai T, Ida H, Minami Y, Takita M, Minami T, Iwanishi M, Chishina H, Ueshima K, Komeda Y, Arizumi T, Kudo M

Dig Dis 34(6) 620-626 2016

Clinical Factors Predicting the Effect of Tolvaptan for Refractory Ascites in Patients with Decompensated Liver Cirrhosis

Chishina H, Hagiwara S, Nishida N, Ueshima K, Sakurai T, Ida H, Minami Y, Takita M, Kono M, Minami T, Iwanishi M, Umehara Y, Watanabe T, Komeda Y, Arizumi T, Kudo M

Dig Dis 34(6) 659-664 2016

Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells Is regulated by NOD1-mediated innate immune responses"

Asano N, Imatani A, Watanabe T, Fushiya J, Kondo Y, Jin X, Ara N, Uno K, Iijima K, Koike T, Strober W, Shimosegawa T

Cancer Res 76(5) 1135-1145 2016 [Refereed]

Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis

Watanabe T., Yagama N., Sadakane Y., Ezoe H., Sakurai T., Chiba T., Kudo M., Strober W.

Mucosal Immunol 9(5) 1234-1249 2016 [Refereed]

The molecular basis of NOD2 risk polymorphisms

Watanabe T, Asano N, Strober W

Autoantibodies and Autoimmunity 31-36 2014

Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation

Y. Arai; Y. Nishinaka; T. Arai; M. Morita; K. Mizugishi; S. Adachi; A. Takaori-Kondo; T. Watanabe; K. Yamashita

Biochemical and Biophysical Research Communications 443(2) 556-561 2014 [Refereed]

NOD2 down-regulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6

Chiba T., Shimosegawa T., Strober W., Watanabe T., Meng G., Asano N., Arai Y., Yamashita K., Kudo M., Sakurai T., Kitani A., Fuss I.J.

Mucosal Immunol 7(6) 1312-1325 2014 [Refereed]

Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer

SAKURAI Toshiharu, KASHIDA Hiroshi, WATANABE Tomohiro, HAGIWARA Satoru, MIZUSHIMA Tsunekazu, IIJIMA Hideki, NISHIDA Naoshi, HIGASHITSUJI Hiroaki, FUJITA Jun, KUDO Masatoshi

Cancer Res 74(21) 6119-6128 2014 [Refereed]

Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn’s disease

STROBER Warren, ASANO Naoki, FUSS Ivan, KITANI Atsushi, WATANABE Tomohiro

Immunological Reviews 260(1) 249-260 2014 [Refereed][Invited]

Familial Mediterranean fever mutations in a patient with recurrent episodes of acute respiratory distress syndrome

Y. Arai; K. Yamashita; K. Mizugishi; T. Watanabe; T. Kondo; T. Kitano; H. Kawabata; N. Kadowaki; A. Takaori-Kondo

Clinical Immunology 147(1) 58-60 2013 [Refereed]

Risk of cancer in patients with autoimmune pancreatitis

M. Shiokawa; Y. Kodama; K. Yoshimura; C. Kawanami; J. Mimura; Y. Yamashita; M. Asada; M. Kikuyama; Y. Okabe; T. Inokuma; M. Ohana; H. Kokuryu; K. Takeda; Y. Tsuji; R. Minami; Y. Sakuma; K. Kuriyama; Y. Ota; W. Tanabe; T. Maruno; A. Kurita; Y. Sawai; N. Uza; T. Watanabe; H. Haga; T. Chiba

American Journal of Gastroenterology 108(4) 610-617 2013 [Refereed]

The implications of myelodysplastic syndrome - associated chromosomal abnormalities in the development of graft-versus-host disease

Y. Arai; K. Yamashita; K. Mizugishi; A. Takaori-Kondo; T. Chiba; T. Watanabe

European Journal of Haematology 90(6) 525-530 2013 [Refereed]

Toll-like receptor activation in basophils contributes to the development of IgG4-related disease

T. Watanabe; K. Yamashita; T. Sakurai; M. Kudo; M. Shiokawa; N. Uza; Y. Kodama; K. Uchida; K. Okazaki; T. Chiba

Journal of Gastroenterology 48(2) 247-253 2013 [Refereed]

Serum Neutrophil Extracellular Trap Levels Predict Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation

Y. Arai; K. Yamashita; K. Mizugishi; T. Watanabe; S. Sakamoto; T. Kitano; T. Kondo; H. Kawabata; N. Kadowaki; A. Takaori-Kondo

Biology of Blood and Marrow Transplantation 19(12) 1683-1689 2013 [Refereed]

Autoimmune hepatitis and immunoglobulin G4-associated autoimmune hepatitis

N. Yada; M. Kudo; H. Chung; T. Watanabe

Digestive Diseases 31(5-6) 415-420 2013 [Refereed]

Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production

T. Sakurai; M. Kudo; T. Watanabe; K. Itoh; H. Higashitsuji; T. Arizumi; T. Inoue; S. Hagiwara; K. Ueshima; N. Nishida; M. Fukumoto; J. Fujita

Digestive Diseases 31(5-6) 440-446 2013 [Refereed]

Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation

A. Takai; H. Marusawa; Y. Minaki; T. Watanabe; H. Nakase; K. Kinoshita; G. Tsujimoto; T. Chiba

Oncogene 31(13) 1733-1742 2012 [Refereed]

P38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression

A.-M. Park; M. Kudo; S. Hagiwara; M. Tabuchi; T. Watanabe; H. Munakata; T. Sakurai

Free Radical Biology and Medicine 52(11-12) 2284-2291 2012 [Refereed]

Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma

S. Hagiwara; M. Kudo; T. Nagai; T. Inoue; K. Ueshima; N. Nishida; T. Watanabe; T. Sakurai

British Journal of Cancer 106(12) 1997-2003 2012 [Refereed]

Involvement of activation of toll-like receptors and nucleotide-binding oligomerization domain-like receptors in enhanced IgG4 responses in autoimmune pancreatitis

T. Watanabe; K. Yamashita; S. Fujikawa; T. Sakurai; M. Kudo; M. Shiokawa; Y. Kodama; K. Uchida; K. Okazaki; T. Chiba

Arthritis and Rheumatism 64(3) 914-924 2012 [Refereed]

Activation of c-Jun N-terminal kinase in non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma

S. Hagiwara; M. Kudo; H. Chung; K. Ueshima; T. Inoue; S. Haji; T. Watanabe; A.-M. Park; H. Munakata; T. Sakurai

Hepatology Research 42(4) 394-400 2012 [Refereed]

Sensing of commensal organisms by the intracellular sensor nod1 mediates experimental pancreatitis

Y. Tsuji; T. Watanabe; M. Kudo; H. Arai; W. Strober; T. Chiba

Immunity 37(2) 326-338 2012 [Refereed]

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

Strober W,Watanabe T

Mucosal Immunol 4(5) 484-495 2011 [Refereed][Invited]

Hemobilia: Another complication associated with anti-thrombotic therapy

Y. Hiramatsu; T. Watanabe; M. Shiokawa; A. Kurita; M. Matsuura; N. Uza; Y. Kodama; T. Chiba

Clinical Journal of Gastroenterology 4(1) 49-51 2011 [Refereed]

Activation of type I IFN signaling by NOD1 mediates mucosal host defense against Helicobacter pylori infection.

T. Watanabe; N. Asano; A. Kitani; I.J. Fuss; T. Chiba; W. Strober

Gut microbes 2 61-65 2011 [Refereed][Invited]

Correlation between hyporesponsiveness to Toll-like receptor ligands and liver dysfunction in patients with chronic hepatitis C virus infection

H. Chung; T. Watanabe; M. Kudo; T. Chiba

Journal of Viral Hepatitis 18(10) 561-567 2011 [Refereed]

Autoimmune pancreatitis exhibiting multiple mass lesions

M. Shiokawa; Y. Kodama; Y. Hiramatsu; A. Kurita; Y. Sawai; N. Uza; T. Watanabe; T. Chiba

Case Reports in Gastroenterology 5(3) 528-533 2011 [Refereed]

Hepatitis C virus core protein induces homotolerance and cross-tolerance to Toll-like receptor ligands by activation of Toll-like receptor 2

H. Chung; T. Watanabe; M. Kudo; T. Chiba

Journal of Infectious Diseases 202(6) 853-861 Sep 2010 [Refereed]

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

T. Watanabe; N. Asano; S. Fichtner-Feigl; P.L. Gorelick; Y. Tsuji; Y. Matsumoto; T. Chiba; I.J. Fuss; A. Kitani; W. Strober

Journal of Clinical Investigation 120(5) 1645-1662 May 2010 [Refereed]

Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease

R. Akitake; T. Watanabe; C. Zaima; N. Uza; H. Ida; S. Tada; N. Nishida; T. Chiba

Gut 59(4) 542-545 Apr 2010 [Refereed]

Identification and characterization of IgG4-associated autoimmune hepatitis

H. Chung; T. Watanabe; M. Kudo; O. Maenishi; Y. Wakatsuki; T. Chiba

Liver International 30(2) 222-231 Feb 2010 [Refereed]

NOD1-mediated mucosal host defense against Helicobacter pylori

Watanabe T, Asano N, Kitani A, Fuss IJ, Chiba T, Strober W

(Jul 15) 476482. 2010 [Refereed][Invited]

Spontaneous rupture of liver plasmacytoma mimicking hepatocellular carcinoma

K. Ueda; H. Matsui; T. Watanabe; J. Seki; T. Ichinohe; Y. Tsuji; K. Matsumura; Y. Sawai; H. Ida; Y. Ueda; T. Chiba

Internal Medicine 49(7) 653-657 2010 [Refereed]

Age and immunoglobulin G4-associated autoimmune hepatitis: Author\ś response

H. Chung; T. Watanabe; M. Kudo; T. Chiba

Liver International 30(2) 333-333 2010 [Refereed]

Defective Interleukin-10 Signaling in Human Inflammatory Bowel Disease

T. Watanabe; T. Chiba

Gastroenterology 138(5) 2016-2018 2010 [Refereed]

Enhanced cytokine responses to Toll-like and NOD-like receptor ligands in primary biliary cirrhosis-CREST overlap syndrome

M. Fukuhara; T. Watanabe; T. Ueo; H. Ida; Y. Kodama; T. Chiba

Rheumatology 49(8) 1602-1604 2010 [Refereed]

Card15 polymorphisms in the immunopathogenesis of Crohn's disease and mycobacterial infectious diseases

Watanabe T, Chiba T,

Gastroenterology 139(6) 2212-2214 2010 [Refereed]

Isoflavones regulate innate immunity and inhibit experimental colitis

M. Morimoto; T. Watanabe; M. Yamori; M. Takebe; Y. Wakatsuki

Journal of Gastroenterology and Hepatology (Australia) 24(6) 1123-1129 Jun 2009 [Refereed]

Massive jejunal bleeding due to Hyde syndrome successfully treated with double balloon endoscopy

Ohta S, Watanabe T, Morita S, Ueno S, Tsuji Y, Nakase H, Chiba T

Clin J Gastroenterol 2(3) 187-189 2009 [Refereed]

Simultaneous occurrence of inflammatory bowel disease and myelodysplastic syndrome due to chromosomal abnormalities in bone marrow cells

F. Nakamura; T. Watanabe; K. Hori; Y. Ohara; K. Yamashita; Y. Tsuji; Y. Ueda; S. Mikami; H. Nakase; T. Chiba

Digestion 79(4) 215-219 2009 [Refereed]

Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers

K. Ikeuchi; H. Marusawa; M. Fujiwara; Y. Matsumoto; Y. Endo; T. Watanabe; A. Iwai; Y. Sakai; R. Takahashi; T. Chiba

International Journal of Cancer 125(9) 2029-2035 2009 [Refereed]

Books etc

Plain Text

ESMO HandBook Immuno-Oncology 2018

Harding JJ, Watanabe T, El-Dika I, Nishida N, Abou-alfa GK, Kudo M, (Part:Joint Work, 2.5 GI Malignancies, 2.5.3 HCC)

2018

Mucosal Immunology 4th Edition

Watanabe T, Chiba T, Strober W (Part:Contributor, Chapter 88 Immune mechanisms of pancreatitis)

Academic Press 2015

Conference Activities & Talks

Plain Text

若年性ポリポーシスより胃切除をした２症例

Tomohiro Watanabe

Nov 2018

表在型食道内分泌癌の一例

Nov 2018

Bleeding after endoscopic resection for early gastric lesions in patients on antithrombotic therapy

Tomohiro Watanabe

UEGW2017 Oct 2017

IL-33 plays a pathogenic role in chronic and autoimmune pancreatitis　 [Invited]

Tomohiro Watanabe

International Congress of Mucosal Immunology Jul 2017

Follow-up examination of the recurrence after endoscopic treatment of colorectal tumors

Komeda Y, Kashida H, Sakurai T, Asakuma Y, Nagai T, Matsui S, Watanabe T, Kudo M

DDW 2017 May 2017

Plasmacytoid dendritic cells producing both IFN-alpha and IL-33 mediate chronic fibro-inflammatory responses in IgG4-related disease

Watanabe T, Kudo M

Feb 2017

Single balloon enteroscopy in the elderly

Tomohiro Watanabe

APDW2016 Nov 2016

NOD2 Downregulates Colonic Inflammation Through IRF-4 Mediated Inhibition of K63 Directed Polyubiquitination of RICK and TRAF6 Molecules [Invited]

Tomohiro Watanabe

2015

Plasmacytoid dendritic cells activated by neutrophil extracellular traps contribute to the pathogenesis of IgG4-related disease

Arai Y, Yamashita K, Watanabe T, Takaori A, Chiba T

Feb 2014

Muramyl dipeptide activation of NOD2 negatively regulates TLR9-induced Th1 chemokine production

Tomohiro Watanabe

14th International Congress of Mucosal Immunogy (Boston) 2009

NOD1 mediates mucosal host defense utilizing a novel mechanims involving the IFN-stimulated gene factor 3 signaling pathway

Watanabe T, Chiba T

Kyoto University Global COE International Symposium / Retreat 2009 2009

Muramyl dipeptide activation of NOD2 inhibits multiple Toll-like receptors pathways vi ainduction of IRF4

Watanabe T, Asano N, Chiba T, Strober W

Dec 2008

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis [Invited]

Watanabe T, Asano N, Murray P, Ozato K, Kitani A, Fuss IJ, Strober W

2008

Muramyl dipeptide activation of NOD2 protects mice from experimental colitis [Invited]

Tomohiro Watanabe

US-Japan GI & Liver Meeting in 21st Century 2008

A liver tolerates to a portal antigen by generating CD11c+ cells wich select regulatory Cd4+ T cells via apoptosis

Watanabe T, Yamori M, ChibaT, Wakatsuki Y

12th International Congress of Mucosal Immunogy (Orlando) Jul 2005

CD4+CD25+ T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen "

Tomohiro Watanabe

12th International Congress of Mucosal Immunogy (Orlando) 2005

Deficient Th1 response to a gastritogenic antigen suppresses cell turnover and augments apoptosis of gastric epithelium

Tomohiro Watanabe

DDW2003 2003

CD4+CD25+ regulatory T cells inhibit antigen-specific colitis by altering the localization of colitogenic CD4+ T cells

Tomohiro Watanabe

DDW 2003 2003

The chemokine response in the stomach is regulated by the host immune status

Tomohiro Watanabe

2002

Differential localization of colitogenic CD4 T cell subsets monospecific to a micro flora-associated antigen in a SCID-transfer model

Tomohiro Watanabe

DDW2002 2002

Development of immunoregulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver

Tomohiro Watanabe

DDW2002 2002

A role played by salivary glands in the induction and maintenance of oral immunization to Helicobacter pylori in the stomach

Tomohiro Watanabe

DDW2001 2001

Peripheral tolerance mediated by CD4 T cells expressing CD95 ligand and screting IL-4 in the liver

Wakatsuki Y, Watanabe T, Chiba T, katsukura H, Kita T

11th International Congress of Mucosal Immunogy 2001

High dose-antigen feeding induces CD4 T cells with suppressor activity in the liver

Tomohiro Watanabe

Immunology 2000 2000

Involvement of intrahepatic lymphocyte in the induction of oral tolerance

Tomohiro Watanabe

10th International Congress of Mucosal Immunology 1999