論文

査読有り
2016年12月

Transcutaneous oxygen pressure as a surrogate Index of lower limb amputation

INTERNATIONAL ANGIOLOGY
  • Hiroomi Nishio
  • ,
  • Kenji Minakata
  • ,
  • Atsushi Kawaguchi
  • ,
  • Motoyuki Kumagai
  • ,
  • Takafumi Ikeda
  • ,
  • Akira Shimizu
  • ,
  • Masayuki Yokode
  • ,
  • Satoshi Morita
  • ,
  • Ryuzo Sakata

35
6
開始ページ
565
終了ページ
572
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
EDIZIONI MINERVA MEDICA

INTRODUCTION: A large number of clinical trials of therapeutic angiogenesis in patients with critical limb ischemia have been conducted in recent years. However, limb amputation, which is used as a primary endpoint in such studies, is not often required in Japan, which can make it difficult to carry out related clinical trials. Transcutaneous oxygen pressure (TcPO2) is widely used to evaluate the severity of limb ischemia, to decide the level of amputation, and to predict wound healing after limb amputation. The aim of the present study was to elucidate whether TcPO2 can be a surrogate index of limb ischemia, and to define an appropriate cutoff value for wound healing after limb amputation using meta-analysis.
EVIDENCE ACQUISITION: A computer search was performed to identify studies describing the association between TcPO2 and limb ischemic events. From these, studies focused on wound healing after limb amputation were combined and analyzed.
EVIDENCE SYNTHESIS: Eleven studies were identified for inclusion in this analysis. The analysis demonstrated that TcPO2 20 mmHg was a valid cutoff value for limb amputation and TcPO2 30 mmHg would be an appropriate value for wound healing after limb amputation.
CONCLUSIONS: TcPO2 of 20 and 30 mmHg were considered appropriate cutoff values for limb amputation and wound healing after amputation, respectively.

Web of Science ® 被引用回数 : 11

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000397703100006&DestApp=WOS_CPL

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