1995年
Plasma levels of type II phospholipase A2 and cytokines in patients with sepsis
Research Communications in Molecular Pathology and Pharmacology
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- 巻
- 90
- 号
- 3
- 開始ページ
- 413
- 終了ページ
- 421
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
Plasma levels of type II phospholipase A2 (type II PLA2), cytokines and endotoxin were determined in patients with sepsis to investigate their interrelations and their role in the patient's prognosis. Type II PLA2 was measured by radioimmunoassay, tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and IL-8 were each measured by enzyme-linked immunosorbent assay (ELISA). Endotoxin was determined by a method based on an endotoxin-specific synthetic substrate. Plasma levels of type II PLA2 were significantly higher in the patients who died of sepsis than in those who survived the illness. There was a significant correlation between type II PLA2 and TNF-α and IL- 6. Type II PLA2, TNF-α, IL-6, and IL-8 may be useful as indices of disease severity. The results suggest that TNF-α and IL-6 stimulate the production of type II PLA2 in the plasma of patients with sepsis.
- リンク情報
- ID情報
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- ISSN : 0034-5164
- PubMed ID : 8746487
- SCOPUS ID : 0029417317