2014年12月
Body Mass Index and Mortality Among Japanese Patients With Type 2 Diabetes: Pooled Analysis of the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- 巻
- 99
- 号
- 12
- 開始ページ
- E2692
- 終了ページ
- E2696
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1210/jc.2014-1855
- 出版者・発行元
- ENDOCRINE SOC
Context: Previous studies on the association between body mass index (BMI) and mortality in diabetes do not necessarily provide a comprehensive view in terms of the global population because of the exclusion of individuals with a BMI less than 18.5 kg/m(2).
Objective: The objective of the study was to examine the association between BMI and mortality.
Design, Setting, and Participants: We analyzed pooled data from 2 cohorts of 2620 Japanese patients with type 2 diabetes followed up for 6.3 years. Patients with a history of cardiovascular disease or cancer were excluded.
Main Outcome Measure: The end point was all-cause mortality. Hazard ratios were estimated by Cox regression adjusted for age, smoking, leisure-time physical activity, and other confounders.
Results: An analysis using BMI categories of 14.4-18.5 (5.2%), 18.5-22.4 (37.3%), 22.5-24.9 (31.0%), and 25.0-37.5 kg/m(2) (26.6%) revealed no significant trend in mortality among patients with a BMI of 18.5 kg/m(2) or greater (trend P = .69). In contrast, the hazard ratio of patients with a BMI less than 18.5 kg/m(2) vs 22.5-24.9 kg/m(2) was 2.58 (95% confidence interval 1.38-4.84; P = .01). Exclusion of deaths in the first 4 years of follow-up decreased the hazard ratio only slightly.
Conclusions: The lowest mortality rate was observed among patients with a BMI of 18.5-24.9 kg/m2, and obesity hadnobenefits regarding mortality. Further research is needed in lean patients, especially among aging populations in East Asia.
Objective: The objective of the study was to examine the association between BMI and mortality.
Design, Setting, and Participants: We analyzed pooled data from 2 cohorts of 2620 Japanese patients with type 2 diabetes followed up for 6.3 years. Patients with a history of cardiovascular disease or cancer were excluded.
Main Outcome Measure: The end point was all-cause mortality. Hazard ratios were estimated by Cox regression adjusted for age, smoking, leisure-time physical activity, and other confounders.
Results: An analysis using BMI categories of 14.4-18.5 (5.2%), 18.5-22.4 (37.3%), 22.5-24.9 (31.0%), and 25.0-37.5 kg/m(2) (26.6%) revealed no significant trend in mortality among patients with a BMI of 18.5 kg/m(2) or greater (trend P = .69). In contrast, the hazard ratio of patients with a BMI less than 18.5 kg/m(2) vs 22.5-24.9 kg/m(2) was 2.58 (95% confidence interval 1.38-4.84; P = .01). Exclusion of deaths in the first 4 years of follow-up decreased the hazard ratio only slightly.
Conclusions: The lowest mortality rate was observed among patients with a BMI of 18.5-24.9 kg/m2, and obesity hadnobenefits regarding mortality. Further research is needed in lean patients, especially among aging populations in East Asia.
- リンク情報
- ID情報
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- DOI : 10.1210/jc.2014-1855
- ISSN : 0021-972X
- eISSN : 1945-7197
- Web of Science ID : WOS:000346743300079