論文

査読有り
2008年11月

The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures

JOURNAL OF BONE AND MINERAL METABOLISM
  • Masataka Shiraki
  • ,
  • Tomohiko Urano
  • ,
  • Tatsuhiko Kuroda
  • ,
  • Mitsuru Saito
  • ,
  • Shiro Tanaka
  • ,
  • Mariko Miyao-Koshizuka
  • ,
  • Satoshi Inoue

26
6
開始ページ
595
終了ページ
602
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00774-008-0878-9
出版者・発行元
SPRINGER TOKYO

A functional polymorphism in methylenetetrahydrofolate reductase (MTHFR) has been identified at codon 677 (C677T). The T-allele variant (valine type) has lower enzyme activity than the wild type (C-allele or alanine type), resulting in a slightly elevated homocysteine level, which has been recently recognized as a risk factor for fracture. However, whether subjects bearing the T allele have higher susceptibility to fractures is still controversial. We have investigated the effects of MTHFR polymorphism on fracture susceptibility in Japanese postmenopausal women. A total of 502 postmenopausal ambulatory Japanese women were followed up for 5.1 +/- 3.4 (mean +/- SD) years, and a total of 155 patients with incident fractures (121 patients with vertebral fractures and 34 cases with fractures at other sites) were recorded. When compared with the patients without any fractures, the patients with incident fractures were older, had more prevalent fractures, had higher urinary levels of bone turnover markers as well as plasma homocysteine level, but were shorter in body height and had lower bone mineral density. The prevalence of the TT genotype of MTHFR was significantly higher in the patients with incident fractures compared to the other genotypes. The subjects with the TT genotype had a higher incidence rate of fracture and higher plasma level of homocysteine than the subjects bearing the non-TT genotype. This relationship was observed in both osteoporotic and nonosteoporotic groups. The hazard ratio for TT genotype without osteoporosis, non-TT genotype with osteoporosis, and TT genotype with osteoporosis was 1.49 (0.91-2.45), 3.64 (2.50-5.29), and 7.21 (4.34-11.97), respectively, compared to the non-TT genotype without osteoporosis. A higher hazard ratio for the TT genotype with osteoporosis was still apparent after adjustment for age, body size, and number of prevalent vertebral fractures. These results indicate that the TT genotype of MTHFR may be a risk factor for future fracture in addition to the traditional risk factors.

リンク情報
DOI
https://doi.org/10.1007/s00774-008-0878-9
CiNii Articles
http://ci.nii.ac.jp/naid/10024460115
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000260551800009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00774-008-0878-9
  • ISSN : 0914-8779
  • CiNii Articles ID : 10024460115
  • Web of Science ID : WOS:000260551800009

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