論文

査読有り
2016年10月

Identification of a predictive factor for distant metastasis in esophageal squamous cell carcinoma after definitive chemoradiotherapy

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
  • Katsuyuki Sakanaka
  • ,
  • Yuichi Ishida
  • ,
  • Satoshi Itasaka
  • ,
  • Yasumasa Ezoe
  • ,
  • Ikuo Aoyama
  • ,
  • Shinichi Miyamoto
  • ,
  • Takahiro Horimatsu
  • ,
  • Manabu Muto
  • ,
  • Masahiro Hiraoka

21
5
開始ページ
899
終了ページ
908
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10147-016-0967-z
出版者・発行元
SPRINGER JAPAN KK

Distant metastasis (DM) after definitive chemoradiotherapy has not been a focus of research in esophageal carcinoma. At present, local-regional control is improving following advances in salvage treatments after definitive chemoradiotherapy. There is a need to focus on suppressing the development of DM. The aim of this study was to identify pre-treatment factors associated with DM after definitive chemoradiotherapy.This study included 144 patients with thoracic esophageal squamous cell carcinoma (Stage I/II/III/IV; 35/17/69/23) (TNM 7th) who underwent definitive chemoradiotherapy; > 50 Gy was prescribed to all gross tumors with concurrent administration of 5-fluorouracil +/- A platinum. Pre-treatment factors included age, gender, performance status, tumor location, T/N/M status, tumor length, size of metastatic lymph nodes (LN size), and the presence of intramural metastasis or multiple primary tumors. The effects of pre-treatment factors on overall survival (OS) and DM were evaluated.The median follow-up period was 48 months. DM occurred as an initial progression in 21 % of patients, and LN size correlated with DM development (hazard ratio [HR] = 5.12; p = 0.0013) and poor OS (HR = 2.20; p = 0.0076) in univariate and multivariate analyses.LN size is a quantitative pre-treatment prognostic factor that should be assessed prior to definitive chemoradiotherapy. Patients with large metastatic lymph nodes are at high risk of DM and should be monitored.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1007/s10147-016-0967-z
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26936851
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000385189700012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s10147-016-0967-z
  • ISSN : 1341-9625
  • eISSN : 1437-7772
  • PubMed ID : 26936851
  • Web of Science ID : WOS:000385189700012

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