論文

査読有り
2018年7月1日

Changes in upper extremity function, ADL, and HRQoL in colorectal cancer patients after the first chemotherapy cycle with oxaliplatin: a prospective single-center observational study

Supportive Care in Cancer
  • Ami Tabata
  • ,
  • Masashi Kanai
  • ,
  • Takahiro Horimatsu
  • ,
  • Tadao Tsuboyama
  • ,
  • Kanae Matsushima
  • ,
  • Toshihiro Kato

26
7
開始ページ
2397
終了ページ
2405
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00520-018-4070-z
出版者・発行元
Springer Verlag

Purpose: Oxaliplatin, an important chemotherapeutic agent in colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN), for which prophylactic or therapeutic interventions are lacking. We aimed to investigate changes in upper extremities, activities of daily living (ADL), and health-related quality of life (HRQoL) parameters after the first chemotherapy cycle. Methods: Thirty-eight colorectal cancer patients scheduled to receive the leucovorin, 5′-fluorouracil, oxaliplatin (FOLFOX) therapy or the capecitabine, oxaliplatin (CAPOX) therapy, participated. Patients underwent objective assessment of sensory function, muscular strength, and manual dexterity and answered the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and the Disabilities of the Arm, Shoulder, and Hand-Disability/Symptom (DASH-DS) questionnaires for subjective assessment. The CIPN was assessed at baseline and prior to the second drug cycle. Results: Light touch sensation in both hands worsened significantly after the first drug cycle, though no significant changes were observed in muscular strength and manual dexterity. The QLQ-C30 analysis showed that Physical Functioning, Role Functioning, Nausea and Vomiting, and Dyspnea were significantly worse, whereas Emotional Functioning was improved. The DASH-DS analysis revealed significant worsening of dysfunction and subjective symptoms. Conclusions: Our results suggest that light touch sensation may worsen even in the absence of multiple chemotherapy cycles. Even if arm and hand function (muscular strength and manual dexterity) is apparently intact, patients may experience dysfunction and decreased HRQoL. For preserving or improving patients’ ADL and HRQoL, it is imperative to provide support at chemotherapy initiation.

リンク情報
DOI
https://doi.org/10.1007/s00520-018-4070-z
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29423680
ID情報
  • DOI : 10.1007/s00520-018-4070-z
  • ISSN : 1433-7339
  • ISSN : 0941-4355
  • PubMed ID : 29423680
  • SCOPUS ID : 85041545265

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