論文

2020年12月

Near-focus magnification and second-generation narrow-band imaging for early gastric cancer in a randomized trial

Journal of Gastroenterology
  • Naomi Kakushima
  • Naohiro Yoshida
  • Hisashi Doyama
  • Tomonori Yano
  • Takahiro Horimatsu
  • Noriya Uedo
  • Yoshinobu Yamamoto
  • Hiromitsu Kanzaki
  • Shinichiro Hori
  • Kenshi Yao
  • Ichiro Oda
  • Satoshi Tanabe
  • Chizu Yokoi
  • Ken Ohata
  • Kenichi Yoshimura
  • Hideki Ishikawa
  • Manabu Muto
  • 全て表示

55
12
開始ページ
1127
終了ページ
1137
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00535-020-01734-3
出版者・発行元
Springer Science and Business Media LLC

BACKGROUND: Magnifying endoscopy with narrow-band imaging (NBI) is effective for the diagnosis of early gastric cancer (EGC). However, magnifying endoscopy is not yet popular globally because of the required level of skill and lack of availability. To overcome these problems, dual-focus endoscopy (standard- and near-focus (NF) modes) has been developed. In this study, we evaluated the diagnostic performance of NF with second-generation (2G)-NBI (NF-NBI) for the diagnosis of EGC. METHODS: This was a secondary analysis of a multicenter randomized controlled trial of 4523 high-risk patients who underwent gastroscopies at 13 institutions in Japan. Patients were randomly assigned to white-light imaging (WLI) followed by 2G-NBI or to 2G-NBI followed by WLI. Lesions suspicious for EGC, newly detected by non-magnifying WLI or 2G-NBI, were subsequently observed with NF-NBI. All detected lesions were biopsied or resected. The diagnostic performance of NF-NBI was compared with the final histology. RESULTS: A total of 870 detected lesions (145 EGC, 725 non-EGC) were analyzed. Overall diagnostic performance for EGC using NF-NBI was accuracy 87.7%, sensitivity 60.7%, specificity 93.1%, positive predictive value 63.8%, and negative predictive value 92.2%. There were no significant differences in diagnostic performance between lesions detected by WLI or 2G-NBI. For lesions diagnosed with high (333 lesions) and low (537 lesions) confidences, accuracy was 92.2% and 84.9%, sensitivity was 64.7% and 58.5%, and specificity was 90.5% and 88.8%, respectively. CONCLUSION: The diagnostic performance of NF-NBI is good and acceptable for diagnosis of EGC in combination with either WLI or 2G-NBI.

リンク情報
DOI
https://doi.org/10.1007/s00535-020-01734-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33021688
URL
http://link.springer.com/content/pdf/10.1007/s00535-020-01734-3.pdf
URL
http://link.springer.com/article/10.1007/s00535-020-01734-3/fulltext.html
ID情報
  • DOI : 10.1007/s00535-020-01734-3
  • ISSN : 0944-1174
  • eISSN : 1435-5922
  • PubMed ID : 33021688

エクスポート
BibTeX RIS