論文

査読有り
2000年11月

Acetaldehyde production by non-pathogenic Neisseria in human oral microflora: Implications for carcinogenesis in upper aerodigestive tract

INTERNATIONAL JOURNAL OF CANCER
  • M Muto
  • ,
  • Y Hitomi
  • ,
  • A Ohtsu
  • ,
  • H Shimada
  • ,
  • Y Kashiwase
  • ,
  • H Sasaki
  • ,
  • S Yoshida
  • ,
  • H Esumi

88
3
開始ページ
342
終了ページ
350
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/1097-0215(20001101)88:3<342::AID-IJC4>3.0.CO;2-I
出版者・発行元
WILEY-BLACKWELL

Many epidemiological studies have identified chronic alcohol consumption as a significant risk factor for cancer of the upper aerodigestive tract (UAT) in human. Although acetaldehyde, the first metabolite from ethanol by alcohol dehydrogenase (ADH), is regarded as a carcinogen, how systemic production of acetaldehyde particularly affects the UAT remains unclear. In our study, we searched for the regional source of acetaldehyde in UAT, especially the involvement of bacteria in the human normal oral microflora. Here we demonstrate that, among the bacterial species identified from the human oral cavity, genus Neisseria had extremely high ADH activity and produced significant amounts of acetaldehyde when cultured with medium containing ethanol in vitro. The ability to produce acetaldehyde was more than 100-fold higher than that produced by any other genera we studied. Furthermore, alcohol ingestion influences the bacterial composition of the oral microflora, resulting in an increased proportion of Neisseria. Although Neisseria present: in normal oral microflora is generally non-pathogenic, these findings suggest that this microbe can be a regional source of carcinogenic acetaldehyde and thus potentially play an important role in alcohol-related carcinogenesis in human UAT. Int. J. Cancer 88:342-350, 2000. (C) 2000 Wiley-Liss. Inc.

リンク情報
DOI
https://doi.org/10.1002/1097-0215(20001101)88:3<342::AID-IJC4>3.0.CO;2-I
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000089710600004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/1097-0215(20001101)88:3<342::AID-IJC4>3.0.CO;2-I
  • ISSN : 0020-7136
  • eISSN : 1097-0215
  • Web of Science ID : WOS:000089710600004

エクスポート
BibTeX RIS