堀部智久 (Tomohisa Horibe) - マイポータル

基本情報

所属: 京都大学

J-GLOBAL ID: 201401037177082014
researchmap会員ID: 7000008744

論文

Increased GADD34 in oligodendrocytes in Alzheimer’s disease.

Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K

Neurosci Lett. 602 50-55 2015年8月査読有り
The Membrane-Lytic Peptides K8L9 and Melittin Enter Cancer Cells via Receptor Endocytosis following Subcytotoxic Exposure

Masayuki Kohno, Tomohisa Horibe, Koji Ohara, Shinji Ito, Koji Kawakami

CHEMISTRY & BIOLOGY 21(11) 1522-1532 2014年11月査読有り
Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide

Tomohisa Horibe, Aya Torisawa, Masayuki Kohno, Koji Kawakami

BMC CANCER 14 615 2014年8月査読有り
Transfection efficiency of normal and cancer cell lines and monitoring of promoter activity by single-cell bioluminescence imaging

Tomohisa Horibe, Aya Torisawa, Ryutaro Akiyoshi, Yoko Hatta-Ohashi, Hirobumi Suzuki, Koji Kawakami

LUMINESCENCE 29(1) 96-100 2014年2月査読有り
Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo

Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Keisuke Sato, Hiroshi Harada, Masahiro Hiraoka, Yasuhiko Tabata, Koji Kawakami

JOURNAL OF CONTROLLED RELEASE 176(1) 1-7 2014年2月査読有り
Protein Disulfide Isomerase P5-Immunopositive Inclusions in Patients with Alzheimer's Disease

Yasuyuki Honjo, Tomohisa Horibe, Aya Torisawa, Hidefumi Ito, Aki Nakanishi, Hiroshi Mori, Tohru Komiya, Ryosuke Takahashi, Koji Kawakami

JOURNAL OF ALZHEIMERS DISEASE 38(3) 601-609 2014年査読有り
Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy.

Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K

International journal of hepatology 2014 584650 2014年査読有り
Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma.

Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K

Oncology reports 29(6) 2147-2153 2013年6月査読有り
HER2-Targeted Hybrid Peptide That Blocks HER2 Tyrosine Kinase Disintegrates Cancer Cell Membrane and Inhibits Tumor Growth In Vivo

Megumi Kawamoto, Tomohisa Horibe, Masayuki Kohno, Koji Kawakami

MOLECULAR CANCER THERAPEUTICS 12(4) 384-393 2013年4月査読有り
Immunogenicity and toxicity of transferrin receptor-targeted hybrid peptide as a potent anticancer agent

Megumi Kawamoto, Masayuki Kohno, Tomohisa Horibe, Koji Kawakami

CANCER CHEMOTHERAPY AND PHARMACOLOGY 71(3) 799-807 2013年3月査読有り
Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle.

Ohara K, Kohno M, Horibe T, Kawakami K

Molecular and clinical oncology 1(2) 231-234 2013年3月査読有り
Effect of lectures by medical students on the awareness of lifestyle for elementary school students.

Hinotsu, S, Yoshikawa, J, Murata, K, Horibe, T, Kawakami, K

J Obesity & Weight loss Ther (in press). 2013年査読有り
Inhibition of Neurite Outgrowth by a Neuropilin-1 Binding Peptide Derived from Semaphorin 3A

M. Kohno, K. Ohara, T. Horibe, K. Kawakami

International Journal of Peptide Research and Therapeutics 1-8 2013年査読有り
Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding

Yoshimi Sato, Rieko Kojima, Masaki Okumura, Masatoshi Hagiwara, Shoji Masui, Ken-Ichi Maegawa, Masatoshi Saiki, Tomohisa Horibe, Mamoru Suzuki, Kenji Inaba

Scientific Reports 3 2456 2013年査読有り
Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells

Tomohisa Horibe, Aya Torisawa, Masayuki Kohno, Koji Kawakami

MOLECULAR CANCER 11 2012年8月査読有り
Derlin-1-immunopositive inclusions in patients with Alzheimer's disease

Yasuyuki Honjo, Hidefumi Ito, Tomohisa Horibe, Hiroyuki Shimada, Aki Nakanishi, Hiroshi Mori, Ryosuke Takahashi, Koji Kawakami

NEUROREPORT 23(10) 611-615 2012年7月査読有り
Cytotoxic activity to acute myeloid leukemia cells by Antp-TPR hybrid peptide targeting Hsp90

Tomohisa Horibe, Megumi Kawamoto, Masayuki Kohno, Koji Kawakami

JOURNAL OF BIOSCIENCE AND BIOENGINEERING 114(1) 96-103 2012年7月査読有り
Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy

Masato Kishida, Kazunori Ishige, Tomohisa Horibe, Noriko Tada, Nobutaka Koibuchi, Junichi Shoda, Kiyoshi Kita, Koji Kawakami

ONCOLOGY LETTERS 3(3) 525-529 2012年3月査読有り
Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells.

Horibe, T, Torisawa, A, Kohno, M, Kawakami, K

Mol Cancer 2012年査読有り
Targeting Interleukin-4 Receptor alpha with Hybrid Peptide for Effective Cancer Therapy

Liying Yang, Tomohisa Horibe, Masayuki Kohno, Mari Haramoto, Koji Ohara, Raj K. Puri, Koji Kawakami

MOLECULAR CANCER THERAPEUTICS 11(1) 235-243 2012年1月査読有り

もっとみる

MISC

Direct association of thioredoxin- 1 (TRX) with macrophage migration inhibitory factor (MIF); Regulatory role TRX on MIF internalization and signaling.

孫安生, 松尾禎之, 堀部智久, 川上浩二, 中村肇, 淀井淳司

第32 回分子生物学会、横浜、2 0 0 9 年12 月11 日 2009年査読有り

書籍等出版物

薬剤の低溶解性の克服

和訳堀部智久, 監修, 川上浩司

Pharm Tech Japan vol 29 (No 4), 143-150 2013年
バイオプロセスにおける純粋培養工程をさらに改良するためのシンプルな戦略

翻訳堀部, 智久, 監修, 川上浩司

Pharm Tech Japan vol28(No 7), 79-92 2012年
再生医療材料の安全性と臨床研究への応用

川上浩司, 堀部智久

実験医学増刊号 28, 152-158 2010年
抗癌分子標的ハイブリッドペプチド

堀部智久, 河野雅之, 一丸大樹, 川上浩司

遺伝子医学MOOK 17号, 103-108 2010年

産業財産権

特願2010-537823 Hsp90を標的にした新規抗癌キメラペプチド

川上浩司, 河野雅之, 堀部智久
特願2011-539160 選択性に優れた抗がんキメラペプチド

川上浩司, 河野雅之, 堀部智久, 中島央美, 楊麗英, 原本真里