2018年
Chemical decontamination of iPS cell-derived neural cell mixtures
Chemical Communications
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- 巻
- 54
- 号
- 11
- 開始ページ
- 1355
- 終了ページ
- 1358
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c7cc08686e
- 出版者・発行元
- Royal Society of Chemistry
This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.
- リンク情報
- ID情報
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- DOI : 10.1039/c7cc08686e
- ISSN : 1364-548X
- ISSN : 1359-7345
- SCOPUS ID : 85041395901