2002年3月
Molecular basis of proton motive force generation: Structure of formate dehydrogenase-N
SCIENCE
- ,
- ,
- ,
- 巻
- 295
- 号
- 5561
- 開始ページ
- 1863
- 終了ページ
- 1868
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.1068186
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a major component of Escherichia coli nitrate respiration, has been determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two heme b groups, and a menaquinone analog. These redox centers are aligned in a single chain, which extends almost 90 angstroms through the enzyme. The menaquinone reduction site associated with a possible proton pathway was also characterized. This structure provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes.
- リンク情報
- ID情報
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- DOI : 10.1126/science.1068186
- ISSN : 0036-8075
- Web of Science ID : WOS:000174299500030