1998年7月
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc(1) complex
SCIENCE
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- 巻
- 281
- 号
- 5373
- 開始ページ
- 64
- 終了ページ
- 71
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.281.5373.64
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Mitochondrial cytochrome bc(1) complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc(1) complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.
- リンク情報
- ID情報
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- DOI : 10.1126/science.281.5373.64
- ISSN : 0036-8075
- Web of Science ID : WOS:000074685800037