2015年3月
A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis
TISSUE ANTIGENS
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- 巻
- 85
- 号
- 3
- 開始ページ
- 204
- 終了ページ
- 208
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/tan.12535
- 出版者・発行元
- WILEY-BLACKWELL
Toll-like receptor 3 (TLR3) may be associated with T helper 1 immune response. This study aimed to investigate the role of a functional TLR3 single nucleotide polymorphism (SNP) in sarcoidosis. We genotyped 220 Japanese patients with sarcoidosis and 140 controls for TLR3SNP rs3775291 to analyze its association with susceptibility to sarcoidosis and assessed its relationship to clinical features in 172 patients over 2years. The TLR3 rs3775291 genotype was not significantly associated with disease susceptibility. However, patients with cardiac sarcoidosis (CS) significantly more frequently had the TT genotype (p<0.01) or the T allele (p<0.05) than those patients without CS. We conclude that TLR3SNP rs3775291 may affect cardiac involvement in Japanese patients with sarcoidosis.
- リンク情報
- ID情報
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- DOI : 10.1111/tan.12535
- ISSN : 0001-2815
- eISSN : 1399-0039
- Web of Science ID : WOS:000350456100008