論文

査読有り
2018年5月18日

Facile Construction of Tetrahydropyrrolizines by Iron-Catalyzed Double Cyclization of Alkene-Tethered Oxime Esters with 1,2-Disubstituted Alkenes

Organic Letters
  • Takuya Shimbayashi
  • ,
  • Daiki Nakamoto
  • ,
  • Kazuhiro Okamoto
  • ,
  • Kouichi Ohe

20
10
開始ページ
3044
終了ページ
3048
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.orglett.8b01073
出版者・発行元
American Chemical Society

The iron-catalyzed cycloaddition reaction of alkene-tethered oxime esters with 1,2-disubstituted alkenes afforded tetrahydropyrrolizines, the structural motif often seen in bicyclic alkaloids. The reaction proceeds through consecutive cycloaddition reactions. These include, first, intramolecular cyclization, followed by intermolecular cyclization with a 1,2-disubstituted alkene in a regioselective manner where an imine moiety first generated plays a pivotal role.

リンク情報
DOI
https://doi.org/10.1021/acs.orglett.8b01073

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