論文

査読有り
2018年1月22日

Asymmetric Synthesis of 2H-Azirines with a Tetrasubstituted Stereocenter by Enantioselective Ring Contraction of Isoxazoles

Angewandte Chemie - International Edition
  • Kazuhiro Okamoto
  • ,
  • Atsushi Nanya
  • ,
  • Akira Eguchi
  • ,
  • Kouichi Ohe

57
4
開始ページ
1039
終了ページ
1043
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/anie.201710920
出版者・発行元
Wiley-VCH Verlag

Highly strained 2H-azirines with a tetrasubstituted stereocenter were synthesized by the enantioselective isomerization of isoxazoles with a chiral diene–rhodium catalyst system. The effect of ligands and the coordination behavior support the proposed catalytic cycle in which the coordination site is fixed in favor of efficient enantiodiscrimination by a bulky substituent of the ligand. In silico studies also support the existence of a rhodium–imido complex as a key intermediate for enantiodiscrimination.

リンク情報
DOI
https://doi.org/10.1002/anie.201710920

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