論文

査読有り
2013年11月

Copper-Catalyzed C-H Cyanation of Terminal Alkynes with Cyanogen Iodide

ORGANIC LETTERS
  • Kazuhiro Okamoto
  • ,
  • Masahito Watanabe
  • ,
  • Naoki Sakata
  • ,
  • Masahito Murai
  • ,
  • Kouichi Ohe

15
22
開始ページ
5810
終了ページ
5813
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/ol402863g
出版者・発行元
AMER CHEMICAL SOC

A copper-catalyzed reaction of terminal alkynes with cyanogen iodide (ICN) that produces alkynyl cyanides has been developed. The use of tetramethylpiperidine as a sterically congested base was successful in this reaction. Some control experiments revealed that the reaction involves the noncatalyzed formation of alkynyl iodides followed by copper-catalyzed cyanation of the iodides without the formation of copper(I) acetylide. This observation contrasts with what is normally observed in various copper-mediated reactions using terminal alkynes.

Web of Science ® 被引用回数 : 27

リンク情報
DOI
https://doi.org/10.1021/ol402863g
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000327175500050&DestApp=WOS_CPL

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