2020年6月1日
Highly swellable hydrogel of regioselectively aminated (1→3)-α-D-glucan crosslinked with ethylene glycol diglycidyl ether
Carbohydrate Polymers
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- 巻
- 237
- 号
- 開始ページ
- 116189
- 終了ページ
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.carbpol.2020.116189
© 2020 Elsevier Ltd (1→3)-α-D-glucan synthesized by glucosyltransferase J (GtfJ) cloned from Streptococcus salivarius was regioselectively aminated as 6-amino-6-deoxy-(1→3)-α-D-glucan (aminoglucan) through three steps: bromination, azidation, and reduction. The degree of substitution of the amino group was determined by elemental analysis to be 0.97 and the molecular weight was 3.74×104 as measured by size exclusion chromatography. The regioselective amination at the C6 position of every pyranose ring was confirmed by 1H/13C NMR and solid state 15N cross polarization/magic angle spinning NMR spectroscopy. Aminoglucan was characterized by FT-IR, X-ray diffraction and thermogravimetric analysis. Solubility of aminoglucan in various solvents was investigated and confirmed in aqueous solution at pH ≤ 11. Therefore, aminoglucan was crosslinked with ethylene glycol diglycidyl ether (EGDE) by an epoxy-ring opening reaction under alkaline conditions. The obtained EGDE-crosslinked aminoglucan hydrogels were highly swellable in water owing to a strong water-holding ability and no water was released on compression and breaking of the gels.
- リンク情報
- ID情報
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- DOI : 10.1016/j.carbpol.2020.116189
- ISSN : 0144-8617
- PubMed ID : 32241412
- SCOPUS ID : 85082624444