論文

査読有り
2002年7月

Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
  • S Ito
  • ,
  • T Fujimori
  • ,
  • Y Hayashizaki
  • ,
  • Y Nabeshima

1576
3
開始ページ
341
終了ページ
345
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0167-4781(02)00281-6
出版者・発行元
ELSEVIER SCIENCE BV

We have identified a novel mouse gene klph (Klotho-LPH related protein; where LPH stands for lactase-phlorizin hydrolase) that encodes a novel mammalian family I glycosidase-like protein. KLPH was a putative type I membrane protein that consists of N-terminal signal sequence, glycosidase domain, transmembrane region and short cytoplasmic tail. Despite its overall structural similarity to other family I glycosidases, the glutamic acid for the acid-base catalyst was not conserved in this protein. klph mRNA was predominantly expressed in the kidney and skin. Epitope-tagged KLPH was localized to the perinuclear tubular network structure of the endoplasmic reticulum in cultured cells. (C) 2002 Elsevier Science B.V. All rights reserved.

Web of Science ® 被引用回数 : 73

リンク情報
DOI
https://doi.org/10.1016/S0167-4781(02)00281-6
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902144348714647
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12084582
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000176716400013&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0167-4781(02)00281-6
  • ISSN : 0167-4781
  • J-Global ID : 200902144348714647
  • PubMed ID : 12084582
  • Web of Science ID : WOS:000176716400013

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