論文

査読有り
2009年2月

Intestinal Hypoxia-inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

CELL METABOLISM
  • Yatrik M. Shah
  • ,
  • Tsutomu Matsubara
  • ,
  • Shinji Ito
  • ,
  • Sun-Hee Yim
  • ,
  • Frank J. Gonzalez

9
2
開始ページ
152
終了ページ
164
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cmet.2008.12.012
出版者・発行元
CELL PRESS

Iron deficiency and iron overload are among the most prevalent nutritional disorders worldwide. Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators of iron absorption. Their expression is increased during high systemic requirements for iron, but the molecular mechanisms that regulate DcytB and DMT1 expression are undefined. Hypoxia-inducible factor (HIF) signaling was induced in the intestine following acute iron deficiency in the duodenum, resulting in activation of DcytB and DMT1 expression and an increase in iron uptake. DcytB and DMT1 were demonstrated as direct HIF-2 alpha target genes. Genetic disruption of HIF signaling in the intestine abolished the adaptive induction of iron absorption following iron deficiency, resulting in low systemic iron and hematological defects. These results demonstrate that HIF signaling in the intestine is a critical regulator of systemic iron homeostasis.

Web of Science ® 被引用回数 : 264

リンク情報
DOI
https://doi.org/10.1016/j.cmet.2008.12.012
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000263269400007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.cmet.2008.12.012
  • ISSN : 1550-4131
  • Web of Science ID : WOS:000263269400007

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