BEGUM Nasim (Nasim Begum) - マイポータル

基本情報

所属: 京都大学

学位: PhD in Biochemistry (Enzymology)

J-GLOBAL ID: 201401007771167341
researchmap会員ID: 7000008861

研究キーワード

研究分野

経歴

学歴

地方独立行政法人大阪府立病院機構大阪府立成人病センター研究所
University of Massachusetts Medical Center, Worcester, USA;, Postdoctoral Training (Cancer Biology; Gene Regulation; Prognostic Marker)
Indian Institute of Chemical Biology and Jadavpur University, Calcutta, India, ( Ph D in Biochemistry )
Visva Bharati University, West Bengal, India, ( B Sc & M Sc in Life Science )

論文

HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

Ahmed M. Refaat, Mikiyo Nakata, Afzal Husain, Hidetaka Kosako, Tasuku Honjo, Nasim A. Begum

Cell Reports 42(3) 112284-112284 2023年3月
Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition.

Nasim A Begum, Farazul Haque, Andre Stanlie, Afzal Husain, Samiran Mondal, Mikiyo Nakata, Takako Taniguchi, Hisaaki Taniguchi, Tasuku Honjo

The EMBO journal 40(12) e106393 2021年6月15日
SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination

Afzal Husain, Jianliang Xu, Hodaka Fujii, Mikiyo Nakata, Maki Kobayashi, Ji-Yang Wang, Jan Rehwinkel, Tasuku Honjo, Nasim A Begum

The EMBO Journal 39(15) 2020年8月3日
RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase

Ziwei Yin, Maki Kobayashi, Wenjun Hu, Koichi Higashi, Nasim A. Begum, Ken Kurokawa, Tasuku Honjo

Proceedings of the National Academy of Sciences 117(21) 11624-11635 2020年5月26日
Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells

Afzal Husain, Nasim Begum, Maki Kobayashi, Tasuku Honjo

BIO-PROTOCOL 10(23) 2020年
Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination

Azza Al Ismail, Afzal Husain, Maki Kobayashi, Tasuku Honjo, Nasim A Begum

International Immunology 29(11) 525-537 2017年12月30日
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins

Samiran Mondal, Nasim A. Begum, Wenjun Hu, Tasuku Honjo

Proceedings of the National Academy of Sciences 113(11) E1545-E1554 2016年3月15日
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi, Tasuku Honjo

Nature Communications 7(1) 2016年2月4日
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase

Wenjun Hu, Nasim A. Begum, Samiran Mondal, Andre Stanlie, Tasuku Honjo

Proceedings of the National Academy of Sciences 112(18) 5791-5796 2015年4月
Molecular Mechanisms of AID Function

Nasim A. Begum, Hitoshi Nagaoka, Maki Kobayashi, Tasuku Honjo

Molecular Biology of B Cells 305-344 2015年
Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination

A. S. Yousif, A. Stanlie, N. A. Begum, T. Honjo

International Immunology 26(10) 575-578 2014年7月3日
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining

Andre Stanlie, Ashraf S. Yousif, Hideo Akiyama, Tasuku Honjo, Nasim A. Begum

Molecular Cell 55(1) 97-110 2014年7月
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase

A. S. Yousif, A. Stanlie, S. Mondal, T. Honjo, N. A. Begum

Proceedings of the National Academy of Sciences 111(11) E1016-E1024 2014年3月3日
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion

Somayeh Sabouri, Maki Kobayashi, Nasim A. Begum, Jianliang Xu, Kouji Hirota, Tasuku Honjo

Proceedings of the National Academy of Sciences 111(6) 2253-2258 2014年2月11日
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation

M. Aida, N. Hamad, A. Stanlie, N. A. Begum, T. Honjo

Proceedings of the National Academy of Sciences 110(19) 7784-7789 2013年4月
The Non-Canonical function of UNG in AID induced Antibody Gene Diversification

Yousif Ashraf, Begum Nasim, Honjo Tasuku

Frontiers in Immunology 4 2013年
The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation

Nasim A. Begum, Andre Stanlie, Mikiyo Nakata, Hideo Akiyama, Tasuku Honjo

Journal of Biological Chemistry 287(39) 32415-32429 2012年7月
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability

Nasim A. Begum, Tasuku Honjo

Biochemistry 51(26) 5243-5256 2012年6月
An Evolutionary View of the Mechanism for Immune and Genome Diversity

Lucia Kato, Andre Stanlie, Nasim A. Begum, Maki Kobayashi, Masatoshi Aida, Tasuku Honjo

The Journal of Immunology 188(8) 3559-3566 2012年4月4日
The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination

Andre Stanlie, Nasim A. Begum, Hideo Akiyama, Tasuku Honjo, Dale A. Ramsden

PLoS Genetics 8(4) 2012年4月

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