2011年2月
Hypofractionated stereotactic radiotherapy for acoustic neuromas: safety and effectiveness over 8 years of experience
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
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- 巻
- 16
- 号
- 1
- 開始ページ
- 27
- 終了ページ
- 32
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s10147-010-0122-1
- 出版者・発行元
- SPRINGER JAPAN KK
Little information is available about long-term outcomes of hypofractionated stereotactic radiotherapy (hypo-FSRT) for acoustic neuromas. In this study, the safety and effectiveness of hypo-FSRT for unilateral acoustic neuroma were reviewed over 8 years of experience at our institution.Between May 1998 and October 2006, 27 patients were consecutively treated by linear accelerator-based hypo-FSRT. Two patients were excluded from this study because they were lost to follow-up within 12 months. The median follow-up period for the rest was 59 (range 24-133) months. Two types of treatment schedules were adopted. Thirteen patients received 30-39 Gy, given in 10-13 fractions (regimen A), whereas after July 2003, 12 patients received 20-24 Gy, given in 5-6 fractions at the tumor periphery (regimen B). These treatments were scheduled to be delivered in three fractions per week (Monday, Wednesday, Friday). The median planning target volume was 2.0, with 1.7 ml (range 0.7-10.6) in regimen A and 5.2 ml (range 0.9-9.3) in regimen B. In the pretreatment audiogram, seven patients (two in regimen A and five in regimen B) had serviceable hearing (Gardner-Robertson Class I-II).Local control rates were 100% with regimen A and 92% with regimen B. Serviceable hearing was preserved in four of five patients in regimen B but no patients in regimen A at the last follow-up. No permanent facial or trigeminal nerve morbidity was observed following treatment, and no salvage surgery was needed.Hypo-FSRT for acoustic neuromas achieved a high local control rate with minimal facial and trigeminal nerve morbidity.
- リンク情報
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- DOI
- https://doi.org/10.1007/s10147-010-0122-1
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201102200254251576
- CiNii Articles
- http://ci.nii.ac.jp/naid/10028173537
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20830603
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000287212500004&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1007/s10147-010-0122-1
- ISSN : 1341-9625
- eISSN : 1437-7772
- J-Global ID : 201102200254251576
- CiNii Articles ID : 10028173537
- PubMed ID : 20830603
- Web of Science ID : WOS:000287212500004