論文

査読有り 筆頭著者 責任著者 国際誌
2018年

Impact of Donor Age on Recipient Survival in Adult-to-Adult Living-donor Liver Transplantation

Annals of Surgery
  • Kubota, T
  • Hata, K
  • Doubl
  • autho
  • Sozu, T
  • Ueda, Y
  • Hirao, H
  • Okamura, Y
  • Tamaki, I
  • Yoshikawa, J
  • Kusakabe, J
  • Tanaka, H
  • Kageyama, S
  • Anazawa, T
  • Yoshizawa, A
  • Yagi, S
  • Yamashiki, N
  • Okajima, H
  • Kaido, T
  • Uemoto, S
  • 全て表示

267
6
開始ページ
1126
終了ページ
1133
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/SLA.0000000000002194

OBJECTIVE: To investigate the influence of donor age on recipient outcome after living-donor partial liver transplantation (LDLT). BACKGROUND: Donor age is a well-known prognostic factor in deceased donor liver transplantation; however, its role in LDLT remains unclear. METHODS: We retrospectively analyzed 315 consecutive cases of primary adult-to-adult LDLT in our center between April 2006 and March 2014. Recipients were divided into 5 groups according to the donor age: D-20s (n = 60); D-30s (n = 72); D-40s (n = 57); D-50s (n = 94); and D-60s (n = 32). The recipient survival and the association with various clinical factors were investigated. RESULTS: Recipient survival proportions were significantly higher in D-20s compared with all the other groups (P = 0.008, < 0.001, < 0.001, and = 0.006, vs D-30s, -40s, -50s, and -60s, respectively), whereas there was no association between recipient survival and their own age. There are 3 typical relationships between donors and recipients in adult-to-adult LDLT: from child-to-parent, between spouses/siblings, and from parent-to-child. The overall survival in child-to-parent was significantly higher than in spouses/siblings (P = 0.002) and in parent-to-child (P = 0.005), despite significantly higher recipient age in child-to-parent [59 (42-69) years, P < 0.001]. Contrastingly, parent-to-child exhibited the lowest survival, despite the youngest recipient age [26 (20-43) years, P < 0.001]. In addition, younger donor age exhibited significantly better recipient survival both in hepatitis C virus-related and in non-hepatitis C virus diseases. Univariate and multivariate analyses both demonstrated that donor age and graft-type (right-sided livers) are independent prognostic factors for recipient survival. CONCLUSIONS: Donor age is an independent, strong prognostic factor in adult-to-adult LDLT.

リンク情報
DOI
https://doi.org/10.1097/SLA.0000000000002194
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28288061
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85015044747&partnerID=MN8TOARS
ID情報
  • DOI : 10.1097/SLA.0000000000002194
  • ISSN : 0003-4932
  • ORCIDのPut Code : 74839399
  • PubMed ID : 28288061
  • SCOPUS ID : 85015044747

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