論文

査読有り 責任著者
2016年9月

Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases

JOURNAL OF NEUROLOGY
  • Hisanori Kinoshita
  • Hodaka Yamakado
  • Toshiyuki Kitano
  • Akihiro Kitamura
  • Hirofumi Yamashita
  • Masakazu Miyamoto
  • Takefumi Hitomi
  • Tomohisa Okada
  • Yuji Nakamoto
  • Nobukatsu Sawamoto
  • Akifumi Takaori-Kondo
  • Ryosuke Takahashi
  • 全て表示

263
9
開始ページ
1719
終了ページ
1726
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00415-016-8190-4
出版者・発行元
SPRINGER HEIDELBERG

Neurolymphomatosis (NL) is a rare condition involving the infiltration of lymphoma cells into the peripheral nervous system. NL can be primary or secondary in the setting of an unknown or known hematologic malignancy, respectively. Here, we report five cases in which F-18 2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (F-18 FDG-PET/CT) had great value for diagnosing NL. Two cases were rare primary NL, and the other three were secondary NL. Clinical presentations were asymmetric sensorimotor disturbances in the extremities with or without involvement of cranial nerves. Furthermore, all patients experienced spontaneous pain in the face or affected extremities. Cerebrospinal fluid analysis was cytologically negative in two of five cases. Gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) detected abnormalities in the cranial nerves, nerve roots, and cauda equina in all cases except case 1 and the recurrent stage of case 2. F-18 FDG-PET/CT showed clear visualization of almost all the lymphomatous involvement of peripheral nerves and other tissues in all patients. Furthermore, F-18 FDG-PET/CT detected abnormalities including asymptomatic lesions that were not detected with MRI, and also identified the appropriate lesion for diagnostic biopsy. However, as in case 3, the lesions in the left oculomotor nerve and the cauda equina were detected only with Gd-enhanced MRI, which has superior spatial resolution. In conclusion, F-18 FDG-PET/CT is a sensitive modality that can suggest the presence of malignancy and identify appropriate places for diagnostic biopsies. It is especially useful when combined with Gd-enhanced MRI, even in patients with primary NL that is usually difficult to diagnose.

リンク情報
DOI
https://doi.org/10.1007/s00415-016-8190-4
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201702203222413632
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27286845
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382638000004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00415-016-8190-4
  • ISSN : 0340-5354
  • eISSN : 1432-1459
  • J-Global ID : 201702203222413632
  • PubMed ID : 27286845
  • Web of Science ID : WOS:000382638000004

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