論文

2019年6月

A New Detection of Biomarker Molecule of α-Synuclein for Parkinson Disease by Phospholipid Liposome-Immobilized Cantilever Microsensor with Temperature Stabilization

2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
  • Ryoko Kobayashi
  • ,
  • Masanori Sawamura
  • ,
  • Hodaka Yamakado
  • ,
  • Masayuki Sohgawa
  • ,
  • Minoru Noda

開始ページ
999
終了ページ
1001
記述言語
掲載種別
研究論文(国際会議プロシーディングス)
DOI
10.1109/TRANSDUCERS.2019.8808657

In this work, for the first time, chronological behavior of α-synuclein (aSyn) as causative agent for Parkinson Disease has been measured by phospholipid liposome-immobilized cantilever microsensor. Our goal is to detect aggregated, not a monomeric, forms of aSyn in its initial stage, as it is most toxic in patient's cerebrospinal fluid (CSF). The aSyn aggregates in phosphate buffered saline (PBS) were successfully detected compared to CSF of healthy person. With a developed temperature stabilization method at room temperature, which was stabilized within +/- 0.2/ °C, aSyn aggregation was detected down to 100 pM.

リンク情報
DOI
https://doi.org/10.1109/TRANSDUCERS.2019.8808657
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071927507&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85071927507&origin=inward
ID情報
  • DOI : 10.1109/TRANSDUCERS.2019.8808657
  • ISBN : 9781728120072
  • SCOPUS ID : 85071927507

エクスポート
BibTeX RIS