2019年6月
A New Detection of Biomarker Molecule of α-Synuclein for Parkinson Disease by Phospholipid Liposome-Immobilized Cantilever Microsensor with Temperature Stabilization
2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
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- 開始ページ
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- 終了ページ
- 1001
- 記述言語
- 掲載種別
- 研究論文(国際会議プロシーディングス)
- DOI
- 10.1109/TRANSDUCERS.2019.8808657
In this work, for the first time, chronological behavior of α-synuclein (aSyn) as causative agent for Parkinson Disease has been measured by phospholipid liposome-immobilized cantilever microsensor. Our goal is to detect aggregated, not a monomeric, forms of aSyn in its initial stage, as it is most toxic in patient's cerebrospinal fluid (CSF). The aSyn aggregates in phosphate buffered saline (PBS) were successfully detected compared to CSF of healthy person. With a developed temperature stabilization method at room temperature, which was stabilized within +/- 0.2/ °C, aSyn aggregation was detected down to 100 pM.
- リンク情報
- ID情報
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- DOI : 10.1109/TRANSDUCERS.2019.8808657
- ISBN : 9781728120072
- SCOPUS ID : 85071927507