論文

査読有り 国際誌
1997年10月30日

Wnt signalling required for expansion of neural crest and CNS progenitors.

Nature
  • M Ikeya
  • ,
  • S M Lee
  • ,
  • J E Johnson
  • ,
  • A P McMahon
  • ,
  • S Takada

389
6654
開始ページ
966
終了ページ
70
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/40146
出版者・発行元
MACMILLAN MAGAZINES LTD

Interactions between cells help to elaborate pattern within the vertebrate central nervous system (CNS). The genes Wnt-1 and Wnt-3a, which encode members of the Wnt family of cysteine-rich secreted signals, are coexpressed at the dorsal midline of the developing neural tube, coincident with dorsal patterning. Each signal is essential for embryonic development, Wnt-1 for midbrain patterning, and Wnt-3a for formation of the paraxial mesoderm, but the absence of a dorsal neural-tube phenotype in each mutant suggests that Wnt signalling may be redundant. Here we demonstrate that in the absence of both Wnt- and Wnt-3a there is a marked deficiency in neural crest derivatives, which originate from the dorsal neural tube, and a pronounced reduction in dorsolateral neural precursors within the neural tube itself. These phenotypes do not seem to result from a disruption in the mechanisms responsible for establishing normal dorsoventral polarity. Rather, our results are consistent with a model in which local Wnt signalling regulates the expansion of dorsal neural precursors. Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS.

リンク情報
DOI
https://doi.org/10.1038/40146
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9353119
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1997YD29900055&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/40146
  • ISSN : 0028-0836
  • PubMed ID : 9353119
  • Web of Science ID : WOS:A1997YD29900055

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