2016年4月
Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types
PLOS ONE
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- 巻
- 11
- 号
- 4
- 開始ページ
- e0154134
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.pone.0154134
- 出版者・発行元
- PUBLIC LIBRARY SCIENCE
Exosome is an extracellular vesicle released from multivesicular endosomes and contains micro (mi) RNAs and functional proteins derived from the donor cells. Exosomal miRNAs act as an effector during communication with appropriate recipient cells, this can aid in the utilization of the exosomes in a drug delivery system for various disorders including malignancies. Differences in the miRNA distribution pattern between exosomes and donor cells indicate the active translocation of miRNAs into the exosome cargos in a miRNA sequence-dependent manner, although the molecular mechanism is little known. In this study, we statistically analyzed the miRNA microarray data and revealed that the guanine (G)-rich sequence is a dominant feature of exosome-dominant miRNAs, across the mammalian species-specificity and the cell types. Our results provide important information regarding the potential use of exosome cargos to develop miRNA-based drugs for the treatment of human diseases.
- リンク情報
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- DOI
- https://doi.org/10.1371/journal.pone.0154134
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27101102
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839687
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000374898500154&DestApp=WOS_CPL
- URL
- http://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/214497
- ID情報
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- DOI : 10.1371/journal.pone.0154134
- ISSN : 1932-6203
- PubMed ID : 27101102
- PubMed Central 記事ID : PMC4839687
- Web of Science ID : WOS:000374898500154