1991年1月1日
Effects of TJ-35 (Shigyaku-san) on Gastric Mucosal Injury Induced by Isefaemia-Reperfusion and Its Oxygen-Derived Free Radical-Scavenging Activities
Journal of Clinical Biochemistry and Nutrition
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- 巻
- 10
- 号
- 開始ページ
- 189
- 終了ページ
- 196
- DOI
- 10.3164/jcbn.10.189
We investigated the effects of TJ-35 (Shigyaku-san) on gastric mucosal injury induced by ischemia-reperfusion in rats; and using the electron spin resonance (ESR) spin trapping method, we also assessed its oxygen-derived free radical-scavenging activities. The increase in mucosal lesions and in thiobarbituric acid-reactive substances (as an index of lipid peroxidation) was significantly inhibited by the oral administration of 500 mg/kg of TJ-35; and in addition, TJ-35 demonstrated superoxide and hydroxyl radical-scavenging activities in vitro. These results suggest the possibility that the effects of TJ-35 on gastric mucosal injury induced by ischemia-reperfusion may be the result of its free radical-scavenging activities. © 1991, SOCIETY FOR FREE RADICAL RESEARCH JAPAN. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.3164/jcbn.10.189
- ISSN : 0912-0009
- SCOPUS ID : 84998344259