MISC

2009年

Metallothionein as an Anti-Inflammatory Mediator

MEDIATORS OF INFLAMMATION
  • Ken-ichiro Inoue
  • ,
  • Hirohisa Takano
  • ,
  • Akinori Shimada
  • ,
  • Masahiko Satoh

記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.1155/2009/101659
出版者・発行元
HINDAWI PUBLISHING CORPORATION

The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. MT expression is induced/enhanced in various tissues by a number of physiological mediators. The cellular accumulation of MT depends on the availability of cellular zinc derived from the diet. MT modulates the binding and exchange/transport of heavy metals such as zinc, cadmium, or copper under physiological conditions and cytoprotection from their toxicities, and the release of gaseous mediators such as hydroxyl radicals or nitric oxide. In addition, MT reportedly affects a number of cellular processes, such as gene expression, apoptosis, proliferation, and differentiation. Given the genetic approach, the apparently healthy status of MT-deficient mice argues against an essential biological role for MT; however, this molecule may be critical in cells/tissues/organs in times of stress, since MT expression is also evoked/enhanced by various stresses. In particular, because metallothionein (MT) is induced by inflammatory stress, its roles in inflammation are implied. Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases. In this paper, we review the role of MT of various inflammatory conditions. Copyright (C) 2009 Ken-ichiro Inoue et al.

リンク情報
DOI
https://doi.org/10.1155/2009/101659
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000266377700001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1155/2009/101659
  • ISSN : 0962-9351
  • Web of Science ID : WOS:000266377700001

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