MISC

2008年11月

Protective Effects of Urinary Trypsin Inhibitor on Systemic Inflammatory Response Induced by Lipopolysaccharide

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
  • Ken-ichiro Inoue
  • ,
  • Hirohisa Takano
  • ,
  • Rie Yanagisawa
  • ,
  • Toshikazu Yoshikawa

43
3
開始ページ
139
終了ページ
142
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
出版者・発行元
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION

Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used in Japan as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation (DIC), shock, and pancreatitis. Recent in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties beyond their inhibition of neutrophil elastase at the site of inflammation. However, the therapeutic effects of UTI in vivo remain unclear. In this review, we introduce the roles of UTI in the experimental systemic inflammatory response induced by both intraperitoneal and intratracheal administration of lipopolysaccharide using UTI deficient and wild-type mice. Our experiments suggest that UTI can protect against systemic inflammatory response and subsequent organ injury induced by bacterial endotoxin, at least partly, through the inhibition of proinflammatory cytokine and chemokine expression. UTI may therefore present an attractive "rescue" therapeutic option for systemic inflammatory response syndromes such as DIC, acute lung injury, and multiple organ dysfunction.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000261350800002&DestApp=WOS_CPL
ID情報
  • ISSN : 0912-0009
  • eISSN : 1880-5086
  • Web of Science ID : WOS:000261350800002

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