2005年3月
Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- 巻
- 35
- 号
- 3
- 開始ページ
- 158
- 終了ページ
- 161
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/jjcolhyi040
- 出版者・発行元
- OXFORD UNIV PRESS
The E-cadherin gene has been identified as having a physiological role in cellular attachment, and is hypothesized to participate in carcinogenesis. A polymorphism (an A to C substitution) in the 5'-untranslated region has a direct effect on E-cadherin gene transcriptional regulation. We explored the association between E-cadherin gene polymorphism and the risk of prostate cancer in a Japanese population. The subjects consisted of 236 patients with prostate cancer, 209 benign prostatic hyperplasia (BPH) patients and 139 male controls. A marginally significant difference was found between prostate cancer patients and male controls (P = 0.053). No significant difference was observed between prostate cancer and BPH patients. When patients with prostate cancer were divided into two groups, stage A+B and stage C+D, a significant difference was observed between progressive cancer patients (stage C+D) and male controls (odds ratio = 1.93, P = 0.016). It is possible that the presence of one A allele resulted in an increased risk of cancer progression.
- リンク情報
-
- DOI
- https://doi.org/10.1093/jjcolhyi040
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902232024399931
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15741307
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000228457100009&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1093/jjcolhyi040
- ISSN : 0368-2811
- J-Global ID : 200902232024399931
- PubMed ID : 15741307
- Web of Science ID : WOS:000228457100009