論文

査読有り 国際誌
2019年1月

Age-related remodelling of oesophageal epithelia by mutated cancer drivers.

Nature
  • Akira Yokoyama
  • Nobuyuki Kakiuchi
  • Tetsuichi Yoshizato
  • Yasuhito Nannya
  • Hiromichi Suzuki
  • Yasuhide Takeuchi
  • Yusuke Shiozawa
  • Yusuke Sato
  • Kosuke Aoki
  • Soo Ki Kim
  • Yoichi Fujii
  • Kenichi Yoshida
  • Keisuke Kataoka
  • Masahiro M Nakagawa
  • Yoshikage Inoue
  • Tomonori Hirano
  • Yuichi Shiraishi
  • Kenichi Chiba
  • Hiroko Tanaka
  • Masashi Sanada
  • Yoshitaka Nishikawa
  • Yusuke Amanuma
  • Shinya Ohashi
  • Ikuo Aoyama
  • Takahiro Horimatsu
  • Shin'ichi Miyamoto
  • Shigeru Tsunoda
  • Yoshiharu Sakai
  • Maiko Narahara
  • J B Brown
  • Yoshitaka Sato
  • Genta Sawada
  • Koshi Mimori
  • Sachiko Minamiguchi
  • Hironori Haga
  • Hiroshi Seno
  • Satoru Miyano
  • Hideki Makishima
  • Manabu Muto
  • Seishi Ogawa
  • 全て表示

565
7739
開始ページ
312
終了ページ
317
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41586-018-0811-x

Clonal expansion in aged normal tissues has been implicated in the development of cancer. However, the chronology and risk dependence of the expansion are poorly understood. Here we intensively sequence 682 micro-scale oesophageal samples and show, in physiologically normal oesophageal epithelia, the progressive age-related expansion of clones that carry mutations in driver genes (predominantly NOTCH1), which is substantially accelerated by alcohol consumption and by smoking. Driver-mutated clones emerge multifocally from early childhood and increase their number and size with ageing, and ultimately replace almost the entire oesophageal epithelium in the extremely elderly. Compared with mutations in oesophageal cancer, there is a marked overrepresentation of NOTCH1 and PPM1D mutations in physiologically normal oesophageal epithelia; these mutations can be acquired before late adolescence (as early as early infancy) and significantly increase in number with heavy smoking and drinking. The remodelling of the oesophageal epithelium by driver-mutated clones is an inevitable consequence of normal ageing, which-depending on lifestyle risks-may affect cancer development.

リンク情報
DOI
https://doi.org/10.1038/s41586-018-0811-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30602793
ID情報
  • DOI : 10.1038/s41586-018-0811-x
  • ISSN : 0028-0836
  • PubMed ID : 30602793

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