2014年3月
Differential Gene Expression in Relation to the Clinical Characteristics of Human Brain Arteriovenous Malformations
NEUROLOGIA MEDICO-CHIRURGICA
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- 巻
- 54
- 号
- 3
- 開始ページ
- 163
- 終了ページ
- 175
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2176/nmc.oa2012-0422
- 出版者・発行元
- JAPAN NEUROSURGICAL SOC
Arteriovenous malformations (AVMs) of the central nervous system are considered as congenital disorders. They are composed of abnormally developed dilated arteries and veins and are characterized microscopically by the absence of a capillary network. We previously reported DNA fragmentation and increased expression of apoptosis-related factors in AVM lesions. In this article, we used microarray analysis to examine differential gene expression in relation to clinical manifestations in 11 AVM samples from Japanese patients. We categorized the genes with altered expression into four groups: death-related, neuron-related, inflammation-related, and other. The death-related differentially expressed genes were MMP9, LIF, SOD2, BCL2A1, MMP12, and HSPA6. The neuron-related genes were NPY, S100A9, NeuroD2, S100Abeta, CAMK2A, SYNPR, CHRM2, and CAMKV. The inflammation-related genes were PTX3, IL8, IL6, CXCL10, GBP1, CHRM3, CXCL1, IL1R2, CCL18, and CCL13. In addition, we compared gene expression in those with or without clinical characteristics including deep drainer, embolization, and high-flow nidus. We identified a small number of genes. Using these microarray data we are able to generate and test new hypotheses to explore AVM pathophysiology. Microarray analysis is a useful technique to study clinical specimens from patients with brain vascular malformations.
- リンク情報
- ID情報
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- DOI : 10.2176/nmc.oa2012-0422
- ISSN : 0470-8105
- eISSN : 1349-8029
- PubMed ID : 24162243
- Web of Science ID : WOS:000349355100001