Ruka Setoguchi

Profile Information

J-GLOBAL ID: 201401022606917424
researchmap Member ID: 7000009149

Research Interests

Research Areas

Life sciences / Immunology / immunological memory, memory CD8 T cells

Research History

Education

2001 - 2005

医学研究科博士課程病理系専攻, 京都大学大学院
1999 - 2001

農学生命科学研究科修士課程応用動物科学専攻, 東京大学大学院
1995 - 1999

Keio University

Committee Memberships

2021 - Present

評議員, 日本免疫学会
2020 - Present

運営委員, Kyoto T Cell Conference

Awards

2018

ベストプレゼンテーション賞, 第 47回日本免疫学会学術集会

瀬戸口留可
2002

Melchers' Travel Award, 日本免疫学会

瀬戸口留可

Papers

Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.

Norihito Hayatsu, Takahisa Miyao, Masashi Tachibana, Ryuichi Murakami, Akihiko Kimura, Takako Kato, Eiryo Kawakami, Takaho A Endo, Ruka Setoguchi, Hiroshi Watarai, Takeshi Nishikawa, Takuwa Yasuda, Hisahiro Yoshida, Shohei Hori

Immunity, 47(2) 268-283, Aug 15, 2017 Peer-reviewed
IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature.

Ruka Setoguchi

International immunology, 28(6) 293-305, Jun, 2016 Peer-reviewed
mTOR signaling promotes a robust and continuous production of IFN-gamma by human memory CD8(+) T cells and their proliferation

Ruka Setoguchi, Yui Matsui, Kousuke Mouri

EUROPEAN JOURNAL OF IMMUNOLOGY, 45(3) 893-902, Mar, 2015 Peer-reviewed
Plasticity of Foxp3(+) T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

Takahisa Miyao, Stefan Floess, Ruka Setoguchi, Herve Luche, Hans Joerg Fehling, Herman Waldmann, Jochen Huehn, Shohei Hori

IMMUNITY, 36(2) 262-275, Feb, 2012 Peer-reviewed
ThPOK Derepression Is Required for Robust CD8 T cell Responses to Viral Infection

Ruka Setoguchi, Ichiro Taniuchi, Michael J. Bevan

JOURNAL OF IMMUNOLOGY, 183(7) 4467-4474, Oct, 2009 Peer-reviewed
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development

Ruka Setoguchi, Masashi Tachibana, Yoshinori Naoe, Sawako Muroi, Kaori Akiyama, Chieko Tezuka, Tsukasa Okuda, Ichiro Taniuchi

SCIENCE, 319(5864) 822-825, Feb, 2008 Peer-reviewed
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells

Atsushi Hijikata, Hiroshi Kitamura, Yayoi Kimura, Ryo Yokoyama, Yuichi Aiba, Yanyuan Bao, Shigeharu Fujita, Koji Hase, Shohei Hori, Yasuyuki Ishii, Osami Kanagawa, Hiroshi Kawamoto, Kazuya Kawano, Haruhiko Koseki, Masato Kubo, Ai Kurita-Miki, Tomohiro Kurosaki, Kyoko Masuda, Mitsumasa Nakata, Keisuke Oboki, Hiroshi Ohno, Mariko Okamoto, Yoshimichi Okayama, Jiyang O-Wang, Hirohisa Saito, Takashi Saito, Machie Sakuma, Katsuaki Sato, Kaori Sato, Ken-Ichiro Seino, Ruka Setoguchi, Yuki Tamura, Masato Tanaka, Masaru Taniguchi, Ichiro Taniuchi, Annabelle Teng, Takeshi Watanabe, Hiroshi Watarai, Sho Yamasaki, Osamu Ohara

BIOINFORMATICS, 23(21) 2934-2941, Nov, 2007 Peer-reviewed
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

Yoshinori Naoe, Ruka Setoguchi, Kaori Akiyama, Sawako Muroi, Masahiko Kuroda, Farah Hatam, Dan R. Littman, Ichiro Taniuchi

JOURNAL OF EXPERIMENTAL MEDICINE, 204(8) 1749-1755, Aug, 2007 Peer-reviewed
Foxp3(+)CD25(+)CD4(+) natural regulatory T cells in dominant self-tolerance and autoimmune disease

Shimon Sakaguchi, Masahiro Ono, Ruka Setoguchi, Haruhiko Yagi, Shohei Hori, Zoltan Fehervari, Jun Shimizu, Takeshi Takahashi, Takashi Nomura

IMMUNOLOGICAL REVIEWS, 212 8-27, Aug, 2006 Peer-reviewed
Naturally arising Foxp3-expressing CD25(+)CD4(+) regulatory T cells in self-tolerance and autoimmune disease

S Sakaguchi, R Setoguchi, H Yagi, T Nomura

CURRENT CONCEPTS IN AUTOIMMUNITY AND CHRONIC INFLAMATION, 305 51-66, 2006 Peer-reviewed
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

R Setoguchi, S Hori, T Takahashi, S Sakaguchi

JOURNAL OF EXPERIMENTAL MEDICINE, 201(5) 723-735, Mar, 2005 Peer-reviewed
IL - 2 and autoimmunity : homeostatic maintenance of CD25＋4＋ regulatory T cells via IL - 2 secreted by other T cells and induction of autoimmune desease by IL - 2 neutralization.

Ruka Setoguchi, Shohei Hori, Takeshi Takahashi, Shimon Sakaguchi

Keystone Symposia Cellular Senescence and Cell Death（2005 3. 3－8. Colorado,USA）, 2005 Peer-reviewed
Setoguchi, R., Hori, S., Takahashi, T., and Sakaguchi, S. A crucial role of IL-2 in the homeostatic maintenance of CD25＋ \nCD4＋ regulatory T cells : induction of autoimmune disease by neutralization of IL-2.

Setoguchi, R, Hori, S, Takahashi, T, Sakaguchi, S

J. Exp. Med. 201 : 723－735,, 2005 Peer-reviewed
内在性制御性T 細胞とサイトカイン実験医学増刊

瀬戸口留可, 坂口志文

実験医学増刊 Vol. 23 No. 20（84－88）, 2005 Peer-reviewed
内在性制御性T 細胞と自己免疫疾患医学のあゆみ

瀬戸口留可, 坂口志文

2005 Vol. 213 No. 1（69－73）, 2005 Peer-reviewed
成熟Ｔ細胞分化と疾患内在性制御性Ｔ細胞と免疫自己寛容

瀬戸口留可, 坂口志文

医学のあゆみ, 211(6) 634-636, Nov 6, 2004 Peer-reviewed
Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3(+)CD25(+)CD4(+) regulatory T cells

E Nishimura, T Sakihama, R Setoguchi, K Tanaka, S Sakaguchi

INTERNATIONAL IMMUNOLOGY, 16(8) 1189-1201, Aug, 2004 Peer-reviewed
Neutralization of IL-2 Breaks Immunological Self-Tolerance by Reducing \nCD25＋4＋ Regulatory T Cells.

R Setoguchi, S Hori, T Takahashi, S Sakaguchi

12th International Congress of Immunology（2004.7.18－23. Montreal Canada）, 2004 Peer-reviewed
Neutralization of IL-2 breaks immunological self-tolerance by reducing the \nnumber of CD25＋4＋regulatory T cells.

Ruka Setoguchi, Shimon Sakaguchi

Keystone Symposia Regulatory/Suppressor T Cells（2004.3.10－15. Banff Canada）, 2004 Peer-reviewed
A crucial role of IL-2 in the homeostatic maintenance of CD25(+)CD4(+) regulatory T cells

R Setoguchi, S Hori, T Takahashi, S Sakaguchi

IMMUNOLOGY 2004: CYTOKINE NETWORK, REGULATORY CELLS, SIGNALING, AND APOPTOSIS, 341-344, 2004 Peer-reviewed

Books and Other Publications

実験医学増刊免疫記憶の制御と疾患治療

瀬戸口留可

羊土社, 2011
Current concepts in autoimmunity and chronic inflammation

Sakaguchi S, Setoguchi R, Yagi H, Nomura T

Springer, 2006
Molecular Medicine 臨時増刊号免疫 2006

瀬戸口留可, 坂口志文

中山書店, 2005
実験医学増刊サイトカインの多彩な機能と臨床応用

瀬戸口留可, 坂口志文

羊土社, 2005
医学のあゆみ

瀬戸口留可、坂口志文

医歯薬出版, 2005

Presentations

Chronic IFN- stimulation impairs memory CD8 T cell maintenance

Ruka Setoguchi

Sep 4, 2020 Invited
持続的な IFN-γシグナルはメモリーCD8T細胞の恒常性破綻を誘導する

瀬戸口留可

第 28 回東京免疫フォーラム, Mar 7, 2019 Invited
メモリーCD8T細胞の恒常性維持機構

瀬戸口留可

第 7 回生命科学阿波おどりシンポジウム, Aug 16, 2017 Invited
IL-15 reverses functionally compromised state of human memory CD8+ T cells

Ruka Setoguchi

Jan 4, 2016 Invited
CD8T細胞の生体内での恒常性維持機構

瀬戸口留可

東京大学農学生命科学研究科獣医学専攻第 44 回獣医学特論, Jun 14, 2014 Invited
MHC class II molecules promote memory CD8 T cell maintenance independently of CD4 help

Ruka Setoguchi

Dec 4, 2010 Invited

Teaching Experience

Research Projects

メモリーCD8T細胞の恒常性を維持するMHCクラスII依存的新規制御機構の解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

瀬戸口留可
Elucidating the molecular basis of memory CD8+ T cell maintenance

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Setoguchi Ruka
メモリーCD8T細胞の恒常性維持機構の解明

加藤記念財団助成金, 加藤記念財団, 2011 - 2012
How MHC class II molecules promote memory CD8 T cell homeostasis

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

SETOGUCHI Ruka
内藤記念海外研究留学助成金, 内藤記念科学振興財団

2006

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Books and Other Publications

Presentations

Teaching Experience

Research Projects

Menu

Coauthors