2012年2月
Asymmetric bilateral effect of the supplementary motor area proper in the human motor system
CLINICAL NEUROPHYSIOLOGY
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- 巻
- 123
- 号
- 2
- 開始ページ
- 324
- 終了ページ
- 334
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.clinph.2011.06.011
- 出版者・発行元
- ELSEVIER IRELAND LTD
Objective: This study aimed to clarify the function of human supplementary motor area proper (SMA) by the single-pulse electric stimulation method and its clinical usefulness for SMA mapping.
Methods: We studied five patients with epilepsy or brain tumour who underwent invasive functional mapping with subdural electrodes. Single-pulse electric stimulation of primary motor area (MI) and SMA was carried out through pairs of subdural electrodes, and motor-evoked potentials (MEPs) were recorded from surface electromyogram on both sides and also cortico-cortical-evoked potentials (CCEPs) from electrocorticogram.
Results: SMA stimulation elicited: (1) MEPs and following silent periods (SPs) in the contralateral upper and lower extremities, (2) SPs with or without minimal MEPs in the ipsilateral upper extremity and (3) CCEPs in the somatotopically corresponding region of the ipsilateral MI. Compared with MI stimulation, SMA stimulation required higher stimulus intensities (mean 14.2 mA (SMA) vs. 8.5 mA (MI)) to elicit MEPs and showed significantly longer onset latencies in upper extremity (range: 4-10 ms).
Conclusions: The results demonstrated an asymmetric bilateral effect of human SMA upon the corticospinal pathway.
Significance: Single-pulse electric cortical stimulation would be clinically useful for distinguishing SMA from MI. The asymmetric bilateral effect of SMA might be conveyed through the direct descending pathway. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Methods: We studied five patients with epilepsy or brain tumour who underwent invasive functional mapping with subdural electrodes. Single-pulse electric stimulation of primary motor area (MI) and SMA was carried out through pairs of subdural electrodes, and motor-evoked potentials (MEPs) were recorded from surface electromyogram on both sides and also cortico-cortical-evoked potentials (CCEPs) from electrocorticogram.
Results: SMA stimulation elicited: (1) MEPs and following silent periods (SPs) in the contralateral upper and lower extremities, (2) SPs with or without minimal MEPs in the ipsilateral upper extremity and (3) CCEPs in the somatotopically corresponding region of the ipsilateral MI. Compared with MI stimulation, SMA stimulation required higher stimulus intensities (mean 14.2 mA (SMA) vs. 8.5 mA (MI)) to elicit MEPs and showed significantly longer onset latencies in upper extremity (range: 4-10 ms).
Conclusions: The results demonstrated an asymmetric bilateral effect of human SMA upon the corticospinal pathway.
Significance: Single-pulse electric cortical stimulation would be clinically useful for distinguishing SMA from MI. The asymmetric bilateral effect of SMA might be conveyed through the direct descending pathway. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.clinph.2011.06.011
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201202222722749782
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21798800
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000299118600020&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.clinph.2011.06.011
- ISSN : 1388-2457
- J-Global ID : 201202222722749782
- PubMed ID : 21798800
- Web of Science ID : WOS:000299118600020