2015年1月
Synthesis of steroidal derivatives bearing a small ring using a catalytic [2+2] cycloaddition and a ring-contraction rearrangement
TETRAHEDRON
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- 巻
- 71
- 号
- 2
- 開始ページ
- 233
- 終了ページ
- 244
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tet.2014.11.065
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Fixing conformation by introducing a ring structure is a common strategy in drug development We demonstrate a synthesis that installs a small carbocyclic ring as a structurally-rigid unit in drug lead compounds. Both trans- and cis-cyclobutane rings were constructed in excellent selectivities by controlling the reaction temperature of an EtAlCl2-catalyzed [2+2] cycloaddition between a silyl enol ether and an alpha,beta-unsaturated ester. Spirocyclopropane rings were stereospecifically formed by our previously reported ring-contraction rearrangement of fused cyclobutanols. This strategy allowed stereodivergent access to a new class of steroidal derivatives bearing a small ring. (C) 2014 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tet.2014.11.065
- ISSN : 0040-4020
- J-Global ID : 201502247214699812
- Web of Science ID : WOS:000348083200002