Hiroshi Kawamoto

Profile Information

Affiliation: Kyoto University

J-GLOBAL ID: 201401058964918224
researchmap Member ID: 7000009192

External link: http://kawamoto.frontier.kyoto-u.ac.jp/index.html

Research Interests

Research Areas

Life sciences / Immunology /

Papers

150

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.

Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, Yasushi Itoh, Hiroshi Kawamoto, Yasutoshi Agata

Molecular therapy oncolytics, 24 77-86, Mar 17, 2022
A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia.

Yukiko Kimura, Eisaku Iwanaga, Kouta Iwanaga, Shinya Endo, Yoshitaka Inoue, Kenji Tokunaga, Yousuke Nagahata, Kyoko Masuda, Hiroshi Kawamoto, Masao Matsuoka

European journal of haematology, 106(3) 327-339, Mar, 2021
Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.

Takuya Maeda, Seiji Nagano, Soki Kashima, Koji Terada, Yasutoshi Agata, Hiroshi Ichise, Manami Ohtaka, Mahito Nakanishi, Fumihiro Fujiki, Haruo Sugiyama, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda, Hiroshi Kawamoto

Molecular therapy. Methods & clinical development, 19 250-260, Dec 11, 2020 Peer-reviewed
[Mass-Production of Cytotoxic T Lymphocytes Regenerated from Pluripotent Stem Cells-To Target Solid Tumors].

Soki Kashima, Kyoko Masuda, Hiroshi Kawamoto

Gan to kagaku ryoho. Cancer & chemotherapy, 47(10) 1415-1420, Oct, 2020
Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer

Masayuki Nagasawa, Kosuke Tomimatsu, Koji Terada, Kenta Kondo, Kazuko Miyazaki, Masaki Miyazaki, Daisuke Motooka, Daisuke Okuzaki, Tetsuya Yoshida, Susumu Kageyama, Hiroshi Kawamoto, Akihiro Kawauchi, Yasutoshi Agata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 526(1) 128-134, May, 2020
Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.

Soki Kashima, Takuya Maeda, Kyoko Masuda, Seiji Nagano, Takamitsu Inoue, Masashi Takeda, Yuka Kono, Takashi Kobayashi, Shigeyoshi Saito, Takahiro Higuchi, Hiroshi Ichise, Yuka Kobayashi, Keiko Iwaisako, Koji Terada, Yasutoshi Agata, Kazuyuki Numakura, Mitsuru Saito, Shintaro Narita, Masaki Yasukawa, Osamu Ogawa, Tomonori Habuchi, Hiroshi Kawamoto

iScience, 23(4) 100998-100998, Apr 24, 2020 Peer-reviewed
High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells.

Seiji Nagano, Takuya Maeda, Hiroshi Ichise, Soki Kashima, Manami Ohtaka, Mahito Nakanishi, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda, Hiroshi Kawamoto

Molecular therapy. Methods & clinical development, 16 126-135, Mar 13, 2020 Peer-reviewed
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells.

Meghan L Good, Raul Vizcardo, Takuya Maeda, Naritaka Tamaoki, Parisa Malekzadeh, Hiroshi Kawamoto, Nicholas P Restifo

Journal of visualized experiments : JoVE, (152), Oct 24, 2019 Peer-reviewed
Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.

Miki Arai Hojo, Kyoko Masuda, Hiroaki Hojo, Yosuke Nagahata, Keiko Yasuda, Daiya Ohara, Yusuke Takeuchi, Keiji Hirota, Yutaka Suzuki, Hiroshi Kawamoto, Shinpei Kawaoka

Nature communications, 10(1) 2603-2603, Jun 13, 2019 Peer-reviewed
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.

Takahito Minami, Takamichi Ishii, Kentaro Yasuchika, Ken Fukumitsu, Satoshi Ogiso, Yuya Miyauchi, Hidenobu Kojima, Takayuki Kawai, Ryoya Yamaoka, Yu Oshima, Hiroshi Kawamoto, Maki Kotaka, Katsutaro Yasuda, Kenji Osafune, Shinji Uemoto

Regenerative therapy, 10 127-133, Jun, 2019 Peer-reviewed
Optimal use of antiplatelet agents, especially aspirin, in the perioperative management of colorectal cancer patients undergoing laparoscopic colorectal resection.

Yoshimoto Y, Fujikawa T, Tanaka A, Hayashi H, Shimoike N, Kawamoto H, Nakasuga C, Yamamoto T

World journal of surgical oncology, 17(1) 92-92, Jun, 2019 Peer-reviewed
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.

Bo Gong, Kazuma Kiyotani, Seiji Sakata, Seiji Nagano, Shun Kumehara, Satoko Baba, Benjamin Besse, Noriko Yanagitani, Luc Friboulet, Makoto Nishio, Kengo Takeuchi, Hiroshi Kawamoto, Naoya Fujita, Ryohei Katayama

The Journal of experimental medicine, 216(4) 982-1000, Apr 1, 2019 Peer-reviewed
Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.

Junko Masuda, Eiji Takayama, Tatsuo Ichinohe, Warren Strober, Masako Mizuno-Kamiya, Tomokatsu Ikawa, Atsushi Kitani, Harumi Kawaki, Ivan Fuss, Hiroshi Kawamoto, Akimasa Seno, Arun Vaidyanath, Naoki Umemura, Akifumi Mizutani, Tomonari Kasai, Yasuko Honjo, Ayano Satoh, Hiroshi Murakami, Yoshimoto Katsura, Nobuo Kondoh, Masaharu Seno

Experimental and therapeutic medicine, 16(5) 4277-4282, Nov, 2018 Peer-reviewed
Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors

Mari Tenno, Satoshi Kojo, Divine-Fondzenyuy Lawir, Isabell Hess, Katsuyuki Shiroguchi, Takashi Ebihara, Takaho A. Endo, Sawako Muroi, Rumi Satoh, Hiroshi Kawamoto, Thomas Boehm, Ichiro Taniuchi

Journal of Experimental Medicine, 215(2) 595-610, Feb 1, 2018 Peer-reviewed
Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells

Tomohiro Miyai, Junichiro Takano, Takaho A. Endo, Eiryo Kawakami, Yasutoshi Agata, Yasutaka Motomura, Masato Kubo, Yukie Kashima, Yutaka Suzuki, Hiroshi Kawamoto, Tomokatsu Ikawa

Genes and Development, 32(2) 112-126, Jan 15, 2018 Peer-reviewed
NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs

Hiroshi Ichise, Seiji Nagano, Takuya Maeda, Masaki Miyazaki, Yuki Miyazaki, Hiroto Kojima, Nobuyo Yawata, Makoto Yawata, Hidenori Tanaka, Hiroh Saji, Kyoko Masuda, Hiroshi Kawamoto

STEM CELL REPORTS, 9(3) 853-867, Sep, 2017 Peer-reviewed
FANTOM5 CAGE profiles of human and mouse samples.

Shuhei Noguchi, Takahiro Arakawa, Shiro Fukuda, Masaaki Furuno, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Kaoru Kaida, Ai Kaiho, Mutsumi Kanamori-Katayama, Tsugumi Kawashima, Miki Kojima, Atsutaka Kubosaki, Ri-Ichiroh Manabe, Mitsuyoshi Murata, Sayaka Nagao-Sato, Kenichi Nakazato, Noriko Ninomiya, Hiromi Nishiyori-Sueki, Shohei Noma, Eri Saijyo, Akiko Saka, Mizuho Sakai, Christophe Simon, Naoko Suzuki, Michihira Tagami, Shoko Watanabe, Shigehiro Yoshida, Peter Arner, Richard A Axton, Magda Babina, J Kenneth Baillie, Timothy C Barnett, Anthony G Beckhouse, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, Ailsa J Carlisle, Hans C Clevers, Carrie A Davis, Michael Detmar, Taeko Dohi, Albert S B Edge, Matthias Edinger, Anna Ehrlund, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Afsaneh Eslami, Michela Fagiolini, Lynsey Fairbairn, Mary C Farach-Carson, Geoffrey J Faulkner, Carmelo Ferrai, Malcolm E Fisher, Lesley M Forrester, Rie Fujita, Jun-Ichi Furusawa, Teunis B Geijtenbeek, Thomas Gingeras, Daniel Goldowitz, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Yuki Hasegawa, Meenhard Herlyn, Peter Heutink, Kelly J Hitchens, David A Hume, Tomokatsu Ikawa, Yuri Ishizu, Chieko Kai, Hiroshi Kawamoto, Yuki I Kawamura, Judith S Kempfle, Tony J Kenna, Juha Kere, Levon M Khachigian, Toshio Kitamura, Sarah Klein, S Peter Klinken, Alan J Knox, Soichi Kojima, Haruhiko Koseki, Shigeo Koyasu, Weonju Lee, Andreas Lennartsson, Alan Mackay-Sim, Niklas Mejhert, Yosuke Mizuno, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Kelly J Morris, Hozumi Motohashi, Christine L Mummery, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Tadasuke Nozaki, Soichi Ogishima, Naganari Ohkura, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A Ovchinnikov, Robert Passier, Margaret Patrikakis, Ana Pombo, Swati Pradhan-Bhatt, Xian-Yang Qin, Michael Rehli, Patrizia Rizzu, Sugata Roy, Antti Sajantila, Shimon Sakaguchi, Hiroki Sato, Hironori Satoh, Suzana Savvi, Alka Saxena, Christian Schmidl, Claudio Schneider, Gundula G Schulze-Tanzil, Anita Schwegmann, Guojun Sheng, Jay W Shin, Daisuke Sugiyama, Takaaki Sugiyama, Kim M Summers, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Andru Tomoiu, Hiroo Toyoda, Marc van de Wetering, Linda M van den Berg, Roberto Verardo, Dipti Vijayan, Christine A Wells, Louise N Winteringham, Ernst Wolvetang, Yoko Yamaguchi, Masayuki Yamamoto, Chiyo Yanagi-Mizuochi, Misako Yoneda, Yohei Yonekura, Peter G Zhang, Silvia Zucchelli, Imad Abugessaisa, Erik Arner, Jayson Harshbarger, Atsushi Kondo, Timo Lassmann, Marina Lizio, Serkan Sahin, Thierry Sengstag, Jessica Severin, Hisashi Shimoji, Masanori Suzuki, Harukazu Suzuki, Jun Kawai, Naoto Kondo, Masayoshi Itoh, Carsten O Daub, Takeya Kasukawa, Hideya Kawaji, Piero Carninci, Alistair R R Forrest, Yoshihide Hayashizaki

Scientific data, 4 170112-170112, Aug 29, 2017 Peer-reviewed
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia

Masafumi Seki, Shunsuke Kimura, Tomoya Isobe, Kenichi Yoshida, Hiroo Ueno, Yaeko Nakajima-Takagi, Changshan Wang, Lin Lin, Ayana Kon, Hiromichi Suzuki, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Kyoko Masuda, Hiroshi Kawamoto, Kentaro Ohki, Motohiro Kato, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Hiroshi Moritake, Masaharu Akiyama, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Akira Oka, Yasuhide Hayashi, Masatoshi Takagi, Atsushi Manabe, Akira Ohara, Keizo Horibe, Masashi Sanada, Atsushi Iwama, Hiroyuki Mano, Satoru Miyano, Seishi Ogawa, Junko Takita

NATURE GENETICS, 49(8) 1274-+, Aug, 2017 Peer-reviewed
The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development

Masaki Miyazaki, Kazuko Miyazaki, Kenian Chen, Yi Jin, Jacob Turner, Amanda J. Moore, Rintaro Saito, Kenichi Yoshida, Seishi Ogawa, Hans-Reimer Rodewald, Yin C. Lin, Hiroshi Kawamoto, Cornelis Murre

IMMUNITY, 46(5) 818-+, May, 2017 Peer-reviewed
Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting

Junko Masuda, Hiroshi Kawamoto, Warren Strober, Eiji Takayama, Akifumi Mizutani, Hiroshi Murakami, Tomokatsu Ikawa, Atsushi Kitani, Narumi Maeno, Tsukasa Shigehiro, Ayano Satoh, Akimasa Seno, Vaidyanath Arun, Tomonari Kasai, Ivan J. Fuss, Yoshimoto Katsura, Masaharu Seno

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 180(8) 1559-1573, Dec, 2016 Peer-reviewed

Misc.

【COVID-19】総論 SARS-CoV-2に対する免疫応答

河本宏

小児内科, 54(1) 23-31, Jan, 2022
Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology

Hiroshi Kawamoto, Kyoko Masuda, Seiji Nagano

International Immunology, Oct 18, 2021
Evolving Paradigm for Blood Cell Differentiation 血液細胞の起源とミエロイド細胞

長畑洋佑, 増田喬子, 河本宏

臨床血液, 62(5) 512-520, May, 2021
Possible NK cell mediated immune responses against iPS-derived regenerated cells in allogenic transplantation

276(8) 809-817, Feb 20, 2021
Possible immune response against iPS-derived regenerated cells in allogenic transplantation

20(1) 16-32, Feb, 2021
Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings.

Kyoko Masuda, Hiroshi Kawamoto

Inflammation and regeneration, 41(1) 2-2, Jan 6, 2021
Development of universal “off-the-shelf” T cells for cancer immunotherapy.

河本宏, 増田喬子, 永野誠治, 永野誠治

月刊腫瘍内科, 27(5), 2021
免疫応答の基本的な仕組み (特集感染症から子どもを守るために : 新型コロナウイルス感染症からの学びとワクチンの最新情報) -- (感染症と免疫・ワクチン)

河本宏

小児科臨床 = Japanese journal of pediatrics, 73(12) 1707-1715, Dec, 2020
Current status and issues in immunology : insight from the historical viewpoint

275(7) 833-841, Nov 14, 2020
【癌と再生医療】多能性幹細胞から再生キラーT細胞を量産固形がんへの応用

嘉島相輝, 増田喬子, 河本宏

癌と化学療法, 47(10) 1415-1420, Oct, 2020
Framework of immune response : cooperation of innate immunity and adaptive immunity

274(3) 309-318, Jul 18, 2020
Development of cancer immunotherapy using CTLs regenerated from iPS cells : To target solid tumor expressing WT1 antigen

273(5) 450-459, May 2, 2020
Development of off-the-shelf T cells for cancer immunotherapy

河本宏, 増田喬子

実験医学, 38(17), 2020
History of cell therapy

河本宏

実験医学, 38(17), 2020
iPS細胞技術を用いたがん抗原特異的CTLの量産他家移植用再生T細胞製剤の開発

河本宏, 永野誠治

癌と化学療法, 46(11) 1677-1682, Nov, 2019
がんと再生医療多能性幹細胞からキラーT細胞を再生他家移植用即納型T細胞製剤の開発

河本宏

日本癌治療学会学術集会抄録集, 57回 SSY15-4, Oct, 2019
【がん免疫療法の個別化を支える新・腫瘍免疫学】第I部腫瘍免疫応答の基本とその制御メカニズム (第2章)腫瘍免疫応答の制御法多能性幹細胞由来免疫細胞を用いたがん免疫療法

河本宏, 増田喬子

実験医学, 37(15) 2562-2570, Sep, 2019
免疫療法の効果と耐性多能幹細胞からCTLを再生即納型T細胞製剤の開発(Cancer immunotherapy sensitivity and resistance Generation of CTLs from pluripotent stem cells: toward the development of "off-the-shelf T cells")

河本宏

日本癌学会総会記事, 78回 S19-4, Sep, 2019
再生医療とがん免疫療法の現状と問題点再生T細胞を用いたがんの免疫細胞療法の開発

河本宏

耳鼻咽喉科免疫アレルギー, 37(2) 29-29, Jun, 2019
【再生医療up to date】【レギュレートリーサイエンス】iPS細胞由来再生細胞を他家移植で用いたときに起こりうる免疫反応

増田喬子, 河本宏

腎と透析, 86(3) 348-355, Mar, 2019

Books and Other Publications

エレガントな免疫

Richtel, Matt, 権田, 敦司, 河本, 宏

ニュートンプレス, Jan, 2022 (ISBN: 9784315525144)
臨床医が知っておくべき免疫学のいま

河本, 宏

医歯薬出版, Aug, 2021
新規の創薬モダリティ細胞医薬 : 細胞を薬として使う、新たな時代の基礎研究と治療法開発

河本, 宏, 辻, 真博

羊土社, Nov, 2020 (ISBN: 9784758103909)
がん免疫療法の突破口(ブレイクスルー)

Graeber, Charles, 中里, ピニングトン京子, 河本, 宏

早川書房, 2020 (ISBN: 9784152099204)
がん免疫療法の誕生 : 科学者25人の物語

Canavan Neil, 河本宏, 三枝小夜子

メディカル・サイエンス・インターナショナル, 2018 (ISBN: 9784815701413)
マンガでわかる免疫学

河本宏, しおざき忍, ビーコムプラス

オーム社, 2014 (ISBN: 9784274050091)
免疫の事典

桂義元, 河本宏, 小安重夫, 山本一彦

朝倉書店, 2011 (ISBN: 9784254310931)
もっとよくわかる!免疫学

河本宏

羊土社, 2011 (ISBN: 9784758122009)

Presentations

iPS 細胞を材料とした即納型汎用性T 細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

大阪大学先導的学際研究機構生命医科学融合フロンティア研究部門シンポジウム, Mar 28, 2022
他家再生細胞を用いた時に起こりうる免疫反応とその制御法の開発

河本宏

第21回日本再生医療学会総会, Mar 19, 2022
TCRカセット法の開発：iPS細胞に安全かつ簡便にTCR遺伝子を導入

河本宏

第21回日本再生医療学会総会, Mar 18, 2022
iPS細胞由来キラーT細胞を用いたCOVID-19治療法の開発

河本宏

第21回日本再生医療学会総会, Mar 17, 2022
即納型T細胞製剤によるがん免疫療法の開発

河本宏

第1回京都大学ウイルス・再生医科学研究所附属ヒトE S細胞研究センターシンポジウム, Mar 9, 2022
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

第34回バイオセラピィ学会学術集会総会, Dec 17, 2021
iPS細胞から作製したT細胞製剤－がんおよびウイルス感染症への応用－

河本宏

第32回日本消化器癌発生学会総会, Nov 27, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－がん免疫療法およびウイルス感染症治療への応用－

河本宏

第39回日本ヒト細胞学会学術集会, Oct 30, 2021
免疫学の基礎と最前線:自己免疫疾患-がん免疫療法から新型コロナ感染症まで-

河本宏

第30回日本小児リウマチ学会学術集会, Oct 16, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－急性骨髄性白血病を対象とした臨床試験に向けて－

河本宏

第29回日本組織適合性学会大会, Sep 3, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－急性骨髄性白血病を対象とした臨床試験に向けて－

河本宏

第42回日本炎症･再生医学会, Jul 8, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－急性骨髄性白血病を対象とした臨床試験に向けて

河本宏

第13回日本血液疾患免疫療法学会学術集会, Jun 19, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－急性骨髄性白血病を対象とした臨床試験に向けて－

河本宏

第30回日本癌病態治療研究会, Jun 11, 2021
iPS細胞を材料とした汎用性即納型T細胞製剤による白血病治療法の開発

河本宏

第18回日本免疫治療学会学術集会, May 23, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－臨床試験に向けた開発と次世代型を目指した改良－

河本宏

第85回インターフェロン・サイトカイン学会学術集会, May 21, 2021
iPS細胞に安全かつ簡便にTCR遺伝子を導入する方法：TCRカセット法の開発

河本宏

第20回日本再生医療学会総会, Mar 13, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－急性骨髄性白血病を対象とした臨床試験に向けて

河本宏

第20回日本再生医療学会総会, Mar 11, 2021
他家再生細胞を用いた時に起こりうる免疫反応とその頻度の予測

河本宏

第20回日本再生医療学会総会, Mar 11, 2021
即納型再生T細胞製剤を用いたがんおよびウイルス感染症の治療法の開発

河本宏

第100回山口県臨床細胞学会学術集会, Mar 7, 2021
Generation of cytotoxic T lymphocytes from iPS cells: Development of “off-the-shelf T cells” for cell therapy targeting cancer and viral infection.

Hiroshi Kawamoto

Japan Healthcare Update Conference, Mar 4, 2021

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Misc.

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