Hiroshi Kawamoto

Profile Information

Affiliation: Kyoto University

J-GLOBAL ID: 201401058964918224
researchmap Member ID: 7000009192

External link: http://kawamoto.frontier.kyoto-u.ac.jp/index.html

Research Interests

Research Areas

Life sciences / Immunology /

Papers

157

Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

Yosuke Nagahata, Kyoko Masuda, Yuji Nishimura, Tomokatsu Ikawa, Shinpei Kawaoka, Toshio Kitawaki, Yasuhito Nannya, Seishi Ogawa, Hiroshi Suga, Yutaka Satou, Akifumi Takaori-Kondo, Hiroshi Kawamoto

Blood, 140(24) 2611-2625, Dec 15, 2022
Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.

Atsushi Tanaka, Taizo A Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue

Blood, 140(8) 875-888, Aug 25, 2022
Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.

Rin Mizuno, Hiroaki Hojo, Masatomo Takahashi, Soshiro Kashio, Sora Enya, Motonao Nakao, Riyo Konishi, Mayuko Yoda, Ayano Harata, Junzo Hamanishi, Hiroshi Kawamoto, Masaki Mandai, Yutaka Suzuki, Masayuki Miura, Takeshi Bamba, Yoshihiro Izumi, Shinpei Kawaoka

Nature communications, 13(1) 3346-3346, Jun 15, 2022
Increase in the incidence of acute inflammatory reactions to injectable fillers during COVID-19 era.

Kiyoko Kato, Eiko Inoue, Sakae Tanaka, Hiroshi Kawamoto

Journal of cosmetic dermatology, 21(5) 1816-1821, May, 2022
Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.

Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, Yasushi Itoh, Hiroshi Kawamoto, Yasutoshi Agata

Molecular therapy oncolytics, 24 77-86, Mar 17, 2022 Peer-reviewed
A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia.

Yukiko Kimura, Eisaku Iwanaga, Kouta Iwanaga, Shinya Endo, Yoshitaka Inoue, Kenji Tokunaga, Yousuke Nagahata, Kyoko Masuda, Hiroshi Kawamoto, Masao Matsuoka

European journal of haematology, 106(3) 327-339, Mar, 2021
Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.

Takuya Maeda, Seiji Nagano, Soki Kashima, Koji Terada, Yasutoshi Agata, Hiroshi Ichise, Manami Ohtaka, Mahito Nakanishi, Fumihiro Fujiki, Haruo Sugiyama, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda, Hiroshi Kawamoto

Molecular therapy. Methods & clinical development, 19 250-260, Dec 11, 2020 Peer-reviewed
[Mass-Production of Cytotoxic T Lymphocytes Regenerated from Pluripotent Stem Cells-To Target Solid Tumors].

Soki Kashima, Kyoko Masuda, Hiroshi Kawamoto

Gan to kagaku ryoho. Cancer & chemotherapy, 47(10) 1415-1420, Oct, 2020
カニクイザルの腫瘍浸潤T細胞から腫瘍殺傷能を有するTCR遺伝子を単離する

近藤健太, 寺田晃士, 石垣宏仁, 里岡大樹, 永野誠治, 増田喬子, 平田多佳子, 小笠原一誠, 伊藤靖, 河本宏, 縣保年

日本がん免疫学会総会プログラム・抄録集, 24回 161-161, Sep, 2020
Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer

Masayuki Nagasawa, Kosuke Tomimatsu, Koji Terada, Kenta Kondo, Kazuko Miyazaki, Masaki Miyazaki, Daisuke Motooka, Daisuke Okuzaki, Tetsuya Yoshida, Susumu Kageyama, Hiroshi Kawamoto, Akihiro Kawauchi, Yasutoshi Agata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 526(1) 128-134, May, 2020
Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.

Soki Kashima, Takuya Maeda, Kyoko Masuda, Seiji Nagano, Takamitsu Inoue, Masashi Takeda, Yuka Kono, Takashi Kobayashi, Shigeyoshi Saito, Takahiro Higuchi, Hiroshi Ichise, Yuka Kobayashi, Keiko Iwaisako, Koji Terada, Yasutoshi Agata, Kazuyuki Numakura, Mitsuru Saito, Shintaro Narita, Masaki Yasukawa, Osamu Ogawa, Tomonori Habuchi, Hiroshi Kawamoto

iScience, 23(4) 100998-100998, Apr 24, 2020 Peer-reviewed
High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells.

Seiji Nagano, Takuya Maeda, Hiroshi Ichise, Soki Kashima, Manami Ohtaka, Mahito Nakanishi, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda, Hiroshi Kawamoto

Molecular therapy. Methods & clinical development, 16 126-135, Mar 13, 2020 Peer-reviewed
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells.

Meghan L Good, Raul Vizcardo, Takuya Maeda, Naritaka Tamaoki, Parisa Malekzadeh, Hiroshi Kawamoto, Nicholas P Restifo

Journal of visualized experiments : JoVE, (152), Oct 24, 2019 Peer-reviewed
Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.

Miki Arai Hojo, Kyoko Masuda, Hiroaki Hojo, Yosuke Nagahata, Keiko Yasuda, Daiya Ohara, Yusuke Takeuchi, Keiji Hirota, Yutaka Suzuki, Hiroshi Kawamoto, Shinpei Kawaoka

Nature communications, 10(1) 2603-2603, Jun 13, 2019 Peer-reviewed
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.

Takahito Minami, Takamichi Ishii, Kentaro Yasuchika, Ken Fukumitsu, Satoshi Ogiso, Yuya Miyauchi, Hidenobu Kojima, Takayuki Kawai, Ryoya Yamaoka, Yu Oshima, Hiroshi Kawamoto, Maki Kotaka, Katsutaro Yasuda, Kenji Osafune, Shinji Uemoto

Regenerative therapy, 10 127-133, Jun, 2019 Peer-reviewed
Optimal use of antiplatelet agents, especially aspirin, in the perioperative management of colorectal cancer patients undergoing laparoscopic colorectal resection.

Yoshimoto Y, Fujikawa T, Tanaka A, Hayashi H, Shimoike N, Kawamoto H, Nakasuga C, Yamamoto T

World journal of surgical oncology, 17(1) 92-92, Jun, 2019 Peer-reviewed
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.

Bo Gong, Kazuma Kiyotani, Seiji Sakata, Seiji Nagano, Shun Kumehara, Satoko Baba, Benjamin Besse, Noriko Yanagitani, Luc Friboulet, Makoto Nishio, Kengo Takeuchi, Hiroshi Kawamoto, Naoya Fujita, Ryohei Katayama

The Journal of experimental medicine, 216(4) 982-1000, Apr 1, 2019 Peer-reviewed
Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.

Junko Masuda, Eiji Takayama, Tatsuo Ichinohe, Warren Strober, Masako Mizuno-Kamiya, Tomokatsu Ikawa, Atsushi Kitani, Harumi Kawaki, Ivan Fuss, Hiroshi Kawamoto, Akimasa Seno, Arun Vaidyanath, Naoki Umemura, Akifumi Mizutani, Tomonari Kasai, Yasuko Honjo, Ayano Satoh, Hiroshi Murakami, Yoshimoto Katsura, Nobuo Kondoh, Masaharu Seno

Experimental and therapeutic medicine, 16(5) 4277-4282, Nov, 2018 Peer-reviewed
Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors

Mari Tenno, Satoshi Kojo, Divine-Fondzenyuy Lawir, Isabell Hess, Katsuyuki Shiroguchi, Takashi Ebihara, Takaho A. Endo, Sawako Muroi, Rumi Satoh, Hiroshi Kawamoto, Thomas Boehm, Ichiro Taniuchi

Journal of Experimental Medicine, 215(2) 595-610, Feb 1, 2018 Peer-reviewed
Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells

Tomohiro Miyai, Junichiro Takano, Takaho A. Endo, Eiryo Kawakami, Yasutoshi Agata, Yasutaka Motomura, Masato Kubo, Yukie Kashima, Yutaka Suzuki, Hiroshi Kawamoto, Tomokatsu Ikawa

Genes and Development, 32(2) 112-126, Jan 15, 2018 Peer-reviewed

Misc.

Overview: innate immunity and adaptive immunity

河本宏

臨床検査, 66(5), 2022
Cancer immunotherapy using T cells regenerated from iPS cells-Development of universal ”off-the-shelf” T cell medicine

河本宏, 増田喬子, 永野誠治

医学のあゆみ, 281(5), 2022
【COVID-19】総論 SARS-CoV-2に対する免疫応答

河本宏

小児内科, 54(1) 23-31, Jan, 2022
Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology

Hiroshi Kawamoto, Kyoko Masuda, Seiji Nagano

International Immunology, Oct 18, 2021
Evolving Paradigm for Blood Cell Differentiation 血液細胞の起源とミエロイド細胞

長畑洋佑, 増田喬子, 河本宏

臨床血液, 62(5) 512-520, May, 2021
Possible NK cell mediated immune responses against iPS-derived regenerated cells in allogenic transplantation

276(8) 809-817, Feb 20, 2021
Possible immune response against iPS-derived regenerated cells in allogenic transplantation

20(1) 16-32, Feb, 2021
Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings.

Kyoko Masuda, Hiroshi Kawamoto

Inflammation and regeneration, 41(1) 2-2, Jan 6, 2021
Development of universal “off-the-shelf” T cells for cancer immunotherapy.

河本宏, 増田喬子, 永野誠治, 永野誠治

月刊腫瘍内科, 27(5), 2021
免疫応答の基本的な仕組み (特集感染症から子どもを守るために : 新型コロナウイルス感染症からの学びとワクチンの最新情報) -- (感染症と免疫・ワクチン)

河本宏

小児科臨床 = Japanese journal of pediatrics, 73(12) 1707-1715, Dec, 2020
Current status and issues in immunology : insight from the historical viewpoint

275(7) 833-841, Nov 14, 2020
【癌と再生医療】多能性幹細胞から再生キラーT細胞を量産固形がんへの応用

嘉島相輝, 増田喬子, 河本宏

癌と化学療法, 47(10) 1415-1420, Oct, 2020
Framework of immune response : cooperation of innate immunity and adaptive immunity

274(3) 309-318, Jul 18, 2020
Development of cancer immunotherapy using CTLs regenerated from iPS cells : To target solid tumor expressing WT1 antigen

273(5) 450-459, May 2, 2020
Development of off-the-shelf T cells for cancer immunotherapy

河本宏, 増田喬子

実験医学, 38(17), 2020
History of cell therapy

河本宏

実験医学, 38(17), 2020
iPS細胞技術を用いたがん抗原特異的CTLの量産他家移植用再生T細胞製剤の開発

河本宏, 永野誠治

癌と化学療法, 46(11) 1677-1682, Nov, 2019
がんと再生医療多能性幹細胞からキラーT細胞を再生他家移植用即納型T細胞製剤の開発

河本宏

日本癌治療学会学術集会抄録集, 57回 SSY15-4, Oct, 2019
【がん免疫療法の個別化を支える新・腫瘍免疫学】第I部腫瘍免疫応答の基本とその制御メカニズム (第2章)腫瘍免疫応答の制御法多能性幹細胞由来免疫細胞を用いたがん免疫療法

河本宏, 増田喬子

実験医学, 37(15) 2562-2570, Sep, 2019
免疫療法の効果と耐性多能幹細胞からCTLを再生即納型T細胞製剤の開発(Cancer immunotherapy sensitivity and resistance Generation of CTLs from pluripotent stem cells: toward the development of "off-the-shelf T cells")

河本宏

日本癌学会総会記事, 78回 S19-4, Sep, 2019

Books and Other Publications

エレガントな免疫

Richtel, Matt, 権田, 敦司, 河本, 宏

ニュートンプレス, Jan, 2022 (ISBN: 9784315525144)
臨床医が知っておくべき免疫学のいま

河本, 宏

医歯薬出版, Aug, 2021
新規の創薬モダリティ細胞医薬 : 細胞を薬として使う、新たな時代の基礎研究と治療法開発

河本, 宏, 辻, 真博

羊土社, Nov, 2020 (ISBN: 9784758103909)
がん免疫療法の突破口(ブレイクスルー)

Graeber, Charles, 中里, ピニングトン京子, 河本, 宏

早川書房, 2020 (ISBN: 9784152099204)
がん免疫療法の誕生 : 科学者25人の物語

Canavan Neil, 河本宏, 三枝小夜子

メディカル・サイエンス・インターナショナル, 2018 (ISBN: 9784815701413)
マンガでわかる免疫学

河本宏, しおざき忍, ビーコムプラス

オーム社, 2014 (ISBN: 9784274050091)
免疫の事典

桂義元, 河本宏, 小安重夫, 山本一彦

朝倉書店, 2011 (ISBN: 9784254310931)
もっとよくわかる!免疫学

河本宏

羊土社, 2011 (ISBN: 9784758122009)

Presentations

Development of “TCR cassette method”: a new method to transduce pluripotent stem cells with exogenous TCR gene.

Hiroshi Kawamoto

ThymOz, Mar 26, 2023
血液細胞の進化的起源をたどるとマクロファージ様の単細胞生物にまで遡れた

河本宏

第7回日本骨免疫学会ウィンタースクール, Feb 1, 2023
Regeneration of cytotoxic T lymphocytes from iPS cells: Development of “off-the-shelf T cells” for cell therapy targeting cancer and viral infection.

Hiroshi Kawamoto

12th AACR-JCA Joint Conference, Dec 11, 2022
Development of off-the-shelf universal T cells derived from iPS cells.

The 81st Annual Meeting of the Japanese Cancer Association, Oct 1, 2022
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－腫瘍浸潤T細胞の再生に向けて－

河本宏

シンポジウム免疫チェックポイント阻害剤ー現在そして未来－, Sep 2, 2022
iPS 細胞を材料とした即納型汎用性T 細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

第42回阿蘇シンポジウム, Jul 23, 2022
細胞医薬の時代の到来：iPS細胞を材料とした汎用性即納型T細胞製剤によるがん免疫療法の開発

河本宏

第26回日本がん免疫学会総会, Jul 21, 2022
iPS細胞由来キラーT細胞を用いたCOVID-19治療法の開発

河本宏

第43回日本炎症・再生医学会, Jul 6, 2022
アレルギーが起こる仕組み：そもそも何のためにある反応？自己免疫疾患との違いは？

河本宏

第38回日本小児臨床アレルギー学会, Jul 3, 2022
T細胞を知る、創る

河本宏

2022 (令和4年) 金沢大学十全医学会学術集会, Jun 14, 2022
腫瘍免疫のいまと今後の展望～iPS細胞技術を用いたがん抗原特異的キラーT細胞の作製～

河本宏

第19回泌尿器科再建再生研究会, Jun 4, 2022
iPS 細胞を材料とした即納型汎用性T 細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

大阪大学先導的学際研究機構生命医科学融合フロンティア研究部門シンポジウム, Mar 28, 2022
他家再生細胞を用いた時に起こりうる免疫反応とその制御法の開発

河本宏

第21回日本再生医療学会総会, Mar 19, 2022
TCRカセット法の開発：iPS細胞に安全かつ簡便にTCR遺伝子を導入

河本宏

第21回日本再生医療学会総会, Mar 18, 2022
iPS細胞由来キラーT細胞を用いたCOVID-19治療法の開発

河本宏

第21回日本再生医療学会総会, Mar 17, 2022
即納型T細胞製剤によるがん免疫療法の開発

河本宏

第1回京都大学ウイルス・再生医科学研究所附属ヒトE S細胞研究センターシンポジウム, Mar 9, 2022
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

第34回バイオセラピィ学会学術集会総会, Dec 17, 2021
iPS細胞から作製したT細胞製剤－がんおよびウイルス感染症への応用－

河本宏

第32回日本消化器癌発生学会総会, Nov 27, 2021
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－がん免疫療法およびウイルス感染症治療への応用－

河本宏

第39回日本ヒト細胞学会学術集会, Oct 30, 2021
免疫学の基礎と最前線:自己免疫疾患-がん免疫療法から新型コロナ感染症まで-

河本宏

第30回日本小児リウマチ学会学術集会, Oct 16, 2021

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