Hiroshi Kawamoto

Profile Information

Affiliation: Kyoto University

J-GLOBAL ID: 201401058964918224
researchmap Member ID: 7000009192

External link: http://kawamoto.frontier.kyoto-u.ac.jp/index.html

Research Interests

Research Areas

Life sciences / Immunology /

Papers

158

Characteristic differences in the abundance of tumor-infiltrating lymphocytes and intratumoral developing T cells in thymoma, with special reference to PD-1 expression.

Tatsuo Furuya, Shunta Ishihara, Hiroshi Ogi, Kyoko Masuda, Saya Shibata, Chiaki Nakazono, Satoru Okada, Masanori Shimomura, So Tando, Takeshi Yaoi …

Cancer immunology, immunotherapy : CII, 72(8) 2585-2596, Apr 15, 2023
Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

Yosuke Nagahata, Kyoko Masuda, Yuji Nishimura, Tomokatsu Ikawa, Shinpei Kawaoka, Toshio Kitawaki, Yasuhito Nannya, Seishi Ogawa, Hiroshi Suga, Yutaka Satou …

Blood, 140(24) 2611-2625, Dec 15, 2022
Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.

Atsushi Tanaka, Taizo A Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama …

Blood, 140(8) 875-888, Aug 25, 2022
Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.

Rin Mizuno, Hiroaki Hojo, Masatomo Takahashi, Soshiro Kashio, Sora Enya, Motonao Nakao, Riyo Konishi, Mayuko Yoda, Ayano Harata, Junzo Hamanishi …

Nature communications, 13(1) 3346-3346, Jun 15, 2022
Increase in the incidence of acute inflammatory reactions to injectable fillers during COVID-19 era.

Kiyoko Kato, Eiko Inoue, Sakae Tanaka, Hiroshi Kawamoto

Journal of cosmetic dermatology, 21(5) 1816-1821, May, 2022
Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.

Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara …

Molecular therapy oncolytics, 24 77-86, Mar 17, 2022 Peer-reviewed
A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia.

Yukiko Kimura, Eisaku Iwanaga, Kouta Iwanaga, Shinya Endo, Yoshitaka Inoue, Kenji Tokunaga, Yousuke Nagahata, Kyoko Masuda, Hiroshi Kawamoto, Masao Matsuoka

European journal of haematology, 106(3) 327-339, Mar, 2021
Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.

Takuya Maeda, Seiji Nagano, Soki Kashima, Koji Terada, Yasutoshi Agata, Hiroshi Ichise, Manami Ohtaka, Mahito Nakanishi, Fumihiro Fujiki, Haruo Sugiyama …

Molecular therapy. Methods & clinical development, 19 250-260, Dec 11, 2020 Peer-reviewed
[Mass-Production of Cytotoxic T Lymphocytes Regenerated from Pluripotent Stem Cells-To Target Solid Tumors].

Soki Kashima, Kyoko Masuda, Hiroshi Kawamoto

Gan to kagaku ryoho. Cancer & chemotherapy, 47(10) 1415-1420, Oct, 2020
カニクイザルの腫瘍浸潤T細胞から腫瘍殺傷能を有するTCR遺伝子を単離する

近藤健太, 寺田晃士, 石垣宏仁, 里岡大樹, 永野誠治, 増田喬子, 平田多佳子, 小笠原一誠, 伊藤靖, 河本宏 …

日本がん免疫学会総会プログラム・抄録集, 24回 161-161, Sep, 2020
Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer

Masayuki Nagasawa, Kosuke Tomimatsu, Koji Terada, Kenta Kondo, Kazuko Miyazaki, Masaki Miyazaki, Daisuke Motooka, Daisuke Okuzaki, Tetsuya Yoshida, Susumu Kageyama …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 526(1) 128-134, May, 2020
Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.

Soki Kashima, Takuya Maeda, Kyoko Masuda, Seiji Nagano, Takamitsu Inoue, Masashi Takeda, Yuka Kono, Takashi Kobayashi, Shigeyoshi Saito, Takahiro Higuchi …

iScience, 23(4) 100998-100998, Apr 24, 2020 Peer-reviewed
High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells.

Seiji Nagano, Takuya Maeda, Hiroshi Ichise, Soki Kashima, Manami Ohtaka, Mahito Nakanishi, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda …

Molecular therapy. Methods & clinical development, 16 126-135, Mar 13, 2020 Peer-reviewed
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells.

Meghan L Good, Raul Vizcardo, Takuya Maeda, Naritaka Tamaoki, Parisa Malekzadeh, Hiroshi Kawamoto, Nicholas P Restifo

Journal of visualized experiments : JoVE, (152), Oct 24, 2019 Peer-reviewed
Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.

Miki Arai Hojo, Kyoko Masuda, Hiroaki Hojo, Yosuke Nagahata, Keiko Yasuda, Daiya Ohara, Yusuke Takeuchi, Keiji Hirota, Yutaka Suzuki, Hiroshi Kawamoto …

Nature communications, 10(1) 2603-2603, Jun 13, 2019 Peer-reviewed
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.

Takahito Minami, Takamichi Ishii, Kentaro Yasuchika, Ken Fukumitsu, Satoshi Ogiso, Yuya Miyauchi, Hidenobu Kojima, Takayuki Kawai, Ryoya Yamaoka, Yu Oshima …

Regenerative therapy, 10 127-133, Jun, 2019 Peer-reviewed
Optimal use of antiplatelet agents, especially aspirin, in the perioperative management of colorectal cancer patients undergoing laparoscopic colorectal resection.

Yoshimoto Y, Fujikawa T, Tanaka A, Hayashi H, Shimoike N, Kawamoto H, Nakasuga C, Yamamoto T

World journal of surgical oncology, 17(1) 92-92, Jun, 2019 Peer-reviewed
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.

Bo Gong, Kazuma Kiyotani, Seiji Sakata, Seiji Nagano, Shun Kumehara, Satoko Baba, Benjamin Besse, Noriko Yanagitani, Luc Friboulet, Makoto Nishio …

The Journal of experimental medicine, 216(4) 982-1000, Apr 1, 2019 Peer-reviewed
Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.

Junko Masuda, Eiji Takayama, Tatsuo Ichinohe, Warren Strober, Masako Mizuno-Kamiya, Tomokatsu Ikawa, Atsushi Kitani, Harumi Kawaki, Ivan Fuss, Hiroshi Kawamoto …

Experimental and therapeutic medicine, 16(5) 4277-4282, Nov, 2018 Peer-reviewed
Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors

Mari Tenno, Satoshi Kojo, Divine-Fondzenyuy Lawir, Isabell Hess, Katsuyuki Shiroguchi, Takashi Ebihara, Takaho A. Endo, Sawako Muroi, Rumi Satoh, Hiroshi Kawamoto …

Journal of Experimental Medicine, 215(2) 595-610, Feb 1, 2018 Peer-reviewed

Misc.

Trends in cell medicine: from autologous cells to allogeneic universal-use cells for adoptive T cell therapies.

Hiroshi Kawamoto, Kyoko Masuda

International immunology, Jan 8, 2024
Development of Immune Cell Therapy Using T Cells Generated from Pluripotent Stem Cells.

Hiroshi Kawamoto, Kyoko Masuda, Seiji Nagano

Advances in experimental medicine and biology, 1444 207-217, 2024
細胞医薬の潮流：自家細胞から他家超汎用性細胞へ

河本宏

炎症と免疫, 31(4) 26-31, Jul, 2023
Development of "Off-the-Shelf" T Cells for Cancer Immunotherapy

50(5) 561-566, May, 2023
自然免疫と獲得免疫：リンパ球の役割

河本宏

ICUとCCU, 47(4) 243-252, Apr, 2023
医学用語解説遺伝子改変T細胞療法の現状と課題

河本宏

炎症と免疫, 31(2) 170-174, Feb, 2023
免疫応答の仕組み：自然免疫と獲得免疫の連携

河本宏

アレルギーの臨床, 43(2) 31-34, Feb, 2023
Evolutionary reversion in tumorigenesis.

Yosuke Nagahata, Hiroshi Kawamoto

Frontiers in oncology, 13 1282417-1282417, 2023
Overview: innate immunity and adaptive immunity

河本宏

臨床検査, 66(5), 2022
Cancer immunotherapy using T cells regenerated from iPS cells-Development of universal ”off-the-shelf” T cell medicine

河本宏, 増田喬子, 永野誠治

医学のあゆみ, 281(5), 2022
【COVID-19】総論 SARS-CoV-2に対する免疫応答

河本宏

小児内科, 54(1) 23-31, Jan, 2022
Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology

Hiroshi Kawamoto, Kyoko Masuda, Seiji Nagano

International Immunology, Oct 18, 2021
Evolving Paradigm for Blood Cell Differentiation 血液細胞の起源とミエロイド細胞

長畑洋佑, 増田喬子, 河本宏

臨床血液, 62(5) 512-520, May, 2021
Possible NK cell mediated immune responses against iPS-derived regenerated cells in allogenic transplantation

276(8) 809-817, Feb 20, 2021
Possible immune response against iPS-derived regenerated cells in allogenic transplantation

20(1) 16-32, Feb, 2021
Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings.

Kyoko Masuda, Hiroshi Kawamoto

Inflammation and regeneration, 41(1) 2-2, Jan 6, 2021
Development of universal “off-the-shelf” T cells for cancer immunotherapy.

河本宏, 増田喬子, 永野誠治, 永野誠治

月刊腫瘍内科, 27(5), 2021
免疫応答の基本的な仕組み (特集感染症から子どもを守るために : 新型コロナウイルス感染症からの学びとワクチンの最新情報) -- (感染症と免疫・ワクチン)

河本宏

小児科臨床 = Japanese journal of pediatrics, 73(12) 1707-1715, Dec, 2020
Current status and issues in immunology : insight from the historical viewpoint

275(7) 833-841, Nov 14, 2020
【癌と再生医療】多能性幹細胞から再生キラーT細胞を量産固形がんへの応用

嘉島相輝, 増田喬子, 河本宏

癌と化学療法, 47(10) 1415-1420, Oct, 2020

Books and Other Publications

エレガントな免疫

Richtel, Matt, 権田, 敦司, 河本, 宏

ニュートンプレス, Jan, 2022 (ISBN: 9784315525144)
臨床医が知っておくべき免疫学のいま

河本, 宏

医歯薬出版, Aug, 2021
新規の創薬モダリティ細胞医薬 : 細胞を薬として使う、新たな時代の基礎研究と治療法開発

河本, 宏, 辻, 真博

羊土社, Nov, 2020 (ISBN: 9784758103909)
がん免疫療法の突破口(ブレイクスルー)

Graeber, Charles, 中里, ピニングトン京子, 河本, 宏

早川書房, 2020 (ISBN: 9784152099204)
がん免疫療法の誕生 : 科学者25人の物語

Canavan Neil, 河本宏, 三枝小夜子

メディカル・サイエンス・インターナショナル, 2018 (ISBN: 9784815701413)
マンガでわかる免疫学

河本宏, しおざき忍, ビーコムプラス

オーム社, 2014 (ISBN: 9784274050091)
免疫の事典

桂義元, 河本宏, 小安重夫, 山本一彦

朝倉書店, 2011 (ISBN: 9784254310931)
もっとよくわかる!免疫学

河本宏

羊土社, 2011 (ISBN: 9784758122009)

Presentations

多能性幹細胞/成熟T細胞に安全かつ簡便にTCR遺伝子を導入する方法:TCRカセット法/カクテル法の開発

河本宏

第23回日本再生医療学会総会, Mar 22, 2024
血液細胞の進化的起源の探索と進化の逆行としてのがん化

河本宏

第8回日本骨免疫学会ウィンタースクール, Feb 1, 2024
iPS 細胞を材料とした即納型汎用性 T 細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

第36回日本バイオセラピィ学会学術集会総会, Dec 14, 2023
Regeneration of cytotoxic T lymphocytes from iPS cells: Development of “off-the-shelf T cells” for cell therapy targeting cancer and viral infection

Hiroshi Kawamoto

The 7th Annual International Congress of Blood and Marrow Transplantation, Sep 2, 2023
免疫を知り、免疫を創る -血液細胞の進化的起源の探索と再生T細胞を用いた細胞療法の開発-

河本宏

第40回分子病理学研究会・クラークシンポジウム, Jul 15, 2023
細胞医薬の時代の到来：多能性幹細胞を材料とした汎用性T細胞製剤によるがん免疫療法の開発

河本宏

第27回日本がん分子標的治療学会学術集会, Jun 21, 2023
細胞を薬のように使う時代が到来－T細胞製剤でがんやウイルス感染症を治す－

河本宏

令和4年度「感染・免疫・がん・炎症」全国共同研究拠点シンポジウム, Mar 29, 2023
Development of “TCR cassette method”: a new method to transduce pluripotent stem cells with exogenous TCR gene.

Hiroshi Kawamoto

ThymOz, Mar 26, 2023
SARS-Cov-2とHLA

河本宏

第21回日本組織適合性学会近畿地方会, Mar 18, 2023
血液細胞の進化的起源をたどるとマクロファージ様の単細胞生物にまで遡れた

河本宏

第7回日本骨免疫学会ウィンタースクール, Feb 1, 2023
Regeneration of cytotoxic T lymphocytes from iPS cells: Development of “off-the-shelf T cells” for cell therapy targeting cancer and viral infection.

Hiroshi Kawamoto

12th AACR-JCA Joint Conference, Dec 11, 2022
Development of off-the-shelf universal T cells derived from iPS cells.

The 81st Annual Meeting of the Japanese Cancer Association, Oct 1, 2022
iPS細胞を材料とした即納型汎用性T細胞製剤の開発－腫瘍浸潤T細胞の再生に向けて－

河本宏

シンポジウム免疫チェックポイント阻害剤ー現在そして未来－, Sep 2, 2022
iPS 細胞を材料とした即納型汎用性T 細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

第42回阿蘇シンポジウム, Jul 23, 2022
細胞医薬の時代の到来：iPS細胞を材料とした汎用性即納型T細胞製剤によるがん免疫療法の開発

河本宏

第26回日本がん免疫学会総会, Jul 21, 2022
iPS細胞由来キラーT細胞を用いたCOVID-19治療法の開発

河本宏

第43回日本炎症・再生医学会, Jul 6, 2022
アレルギーが起こる仕組み：そもそも何のためにある反応？自己免疫疾患との違いは？

河本宏

第38回日本小児臨床アレルギー学会, Jul 3, 2022
T細胞を知る、創る

河本宏

2022 (令和4年) 金沢大学十全医学会学術集会, Jun 14, 2022
腫瘍免疫のいまと今後の展望～iPS細胞技術を用いたがん抗原特異的キラーT細胞の作製～

河本宏

第19回泌尿器科再建再生研究会, Jun 4, 2022
iPS 細胞を材料とした即納型汎用性T 細胞製剤の開発－がんおよびウイルス感染症への応用－

河本宏

大阪大学先導的学際研究機構生命医科学融合フロンティア研究部門シンポジウム, Mar 28, 2022

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