2004年1月
Epigenetic dynamics of imprinted X inactivation during early mouse development
SCIENCE
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- 巻
- 303
- 号
- 5658
- 開始ページ
- 644
- 終了ページ
- 649
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.1092727
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modi. cations and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo.
- リンク情報
- ID情報
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- DOI : 10.1126/science.1092727
- ISSN : 0036-8075
- Web of Science ID : WOS:000188530800032