2006年
The dynamics of imprinted X inactivation during preimplantation development in mice
CYTOGENETIC AND GENOME RESEARCH
- ,
- 巻
- 113
- 号
- 1-4
- 開始ページ
- 318
- 終了ページ
- 324
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000090848
- 出版者・発行元
- KARGER
In the mouse, there are two forms of X chromosome inactivation (XCI), random XCI in the fetus and imprinted paternal XCI, which is limited to the extraembryonic tissues. While the mechanism of random XCI has been studied extensively using the in vitro XX ES cell differentiation system, imprinted XCI during early embryonic development has been less well characterized. Recent studies of early embryos have reported unexpected findings for the paternal X chromosome (Xp). Imprinted XCI may not be linked to meiotic silencing in the male germ line but rather to the imprinted status of the Xist gene. Furthermore, the Xp becomes inactivated in all cells of cleavage-stage embryos and then reactivated in the cells of the inner cell mass (ICM) that form the epiblast, where random XCI ensues.
- リンク情報
- ID情報
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- DOI : 10.1159/000090848
- ISSN : 1424-8581
- Web of Science ID : WOS:000238614500042