Takashi Mino

Profile Information

Affiliation: Kyoto University

Degree: 博士(工学)(京都大学)

ORCID ID: https://orcid.org/0000-0002-9562-008X
J-GLOBAL ID: 201401051154453867
researchmap Member ID: 7000009274

Research Interests

Research Areas

Research History

Apr, 2019 - Present

Assistant Professor, Graduate School of Medicine, Kyoto University
Oct, 2016 - Mar, 2019

Assistant Professor, Institute for Frontier Life and Medical Sciences, Kyoto University
Jun, 2012 - Sep, 2016

Assistant Professor, Institute for Virus Research, Kyoto University
Apr, 2010 - Jun, 2012

Specially Appointed Researcher, WPI Immunology Frontier Research Center, Osaka University
Apr, 2009 - Mar, 2010

Postdoctoral Fellow, School of Medicine, The University of California, San Diego
Apr, 2007 - Mar, 2009

JSPS Research Fellow, Graduate School of Engineering Department of Synthetic Chemistry and Biological Chemistry, Kyoto University

Education

Apr, 2006 - Mar, 2009

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
Apr, 2004 - Mar, 2006

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
Apr, 2002 - Mar, 2004

School of Industrial Chemistry, Faculty of Engineering, Kyoto University

Awards

Papers

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.

Takuya Uehata, Shinnosuke Yamada, Daisuke Ori, Alexis Vandenbon, Amir Giladi, Adam Jelinski, Yasuhiro Murakawa, Hitomi Watanabe, Kazuhiro Takeuchi, Kazunori Toratani …

Blood, Nov 3, 2023
Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.

Ai Yaku, Tadakatsu Inagaki, Ryotaro Asano, Makoto Okazawa, Hiroyoshi Mori, Ayuko Sato, Fabian Hia, Takeshi Masaki, Yusuke Manabe, Tomohiko Ishibashi …

Circulation, 101161CIRCULATIONAHA122059435, Aug 23, 2022 Peer-reviewed
DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex

Kotaro Akaki, Takashi Mino, Osamu Takeuchi

BIO-PROTOCOL, 12(15), Aug, 2022 Peer-reviewed
Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases.

Ka Man Tse, Alexis Vandenbon, Xiaotong Cui, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga …

Science translational medicine, 14(644) eabo2137, May 11, 2022
Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism.

Yee Kien Chong, Sarang Tartey, Yuki Yoshikawa, Koshi Imami, Songling Li, Masanori Yoshinaga, Ai Hirabayashi, Guohao Liu, Alexis Vandenbon, Fabian Hia …

Science signaling, 15(729) eabm5011, Apr 12, 2022
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

Kotaro Akaki, Kosuke Ogata, Yuhei Yamauchi, Noriki Iwai, Ka Man Tse, Fabian Hia, Atsushi Mochizuki, Yasushi Ishihama, Takashi Mino, Osamu Takeuchi

eLife, 10, Oct 12, 2021
Regnase-1-related endoribonucleases in health and immunological diseases.

Takashi Mino, Osamu Takeuchi

Immunological reviews, Sep 12, 2021
Extracellular mRNA transported to the nucleus exerts translation-independent function.

Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-Ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi …

Nature communications, 12(1) 3655-3655, Jun 16, 2021
Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1

Yoshinari Nakatsuka, Ai Yaku, Tomohiro Handa, Alexis Vandenbon, Yuki Hikichi, Yasutaka Motomura, Ayuko Sato, Masanori Yoshinaga, Kiminobu Tanizawa, Kizuku Watanabe …

European Respiratory Journal, 57(3) 2000018-2000018, Sep 25, 2020 Peer-reviewed
N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

Daichi Yamasoba, Kei Sato, Takuya Ichinose, Tomoko Imamura, Lennart Koepke, Simone Joas, Elisabeth Reith, Dominik Hotter, Naoko Misawa, Kotaro Akaki …

Nature Microbiology, 4(9) 1532-1544, Sep, 2019 Peer-reviewed
Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs

Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki …

Nucleic Acids Research, 47(16)(16) 8838-8859, Jul 22, 2019 Peer-reviewedLead author
Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.

Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato …

Mucosal immunology, 11(4) 1203-1218, Jul, 2018 Peer-reviewed
Post-transcriptional regulation of immune responses by RNA binding proteins

Takashi Mino, Osamu Takeuchi

Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 94(6) 248-258, 2018 Peer-reviewed
NSD3 keeps IRF3 active

Takashi Mino, Osamu Takeuchi

JOURNAL OF EXPERIMENTAL MEDICINE, 214(12) 3475-3476, Dec, 2017 Peer-reviewedInvited
Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis

Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata …

JOURNAL OF IMMUNOLOGY, 199(12) 4066-4077, Dec, 2017 Peer-reviewed
Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs

Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi

CELL REPORTS, 19(8) 1614-1630, May, 2017 Peer-reviewed
Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin

Takashi Mino, Osamu Takeuchi

Folia Pharmacologica Japonica, 147(6) 351-356, 2016 Peer-reviewed
Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses

Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi

JOURNAL OF IMMUNOLOGY, 195(2) 519-527, Jul, 2015 Peer-reviewed
Regnase-1 and Roquin regulate inflammatory mRNAs

Takashi Mino, Osamu Takeuchi

ONCOTARGET, 6(20) 17869-17870, Jul, 2015 Peer-reviewedInvited
Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki …

CELL, 161(5) 1058-1073, May, 2015 Peer-reviewed

Misc.

鉄代謝を制御する転写後調節機構の解明

吉永正憲, 三野享史, BASSIK Michael C, 竹内理

日本RNA学会年会要旨集, 20th, 2018
Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

吉永正憲, 三野享史, 竹内理

日本分子生物学会年会プログラム・要旨集(Web), 41st, 2018
Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity

Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi

CYTOKINE, 100 39-39, Dec, 2017
Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

吉永正憲, 三野享史, 竹内理

日本生化学会大会(Web), 90th, 2017
Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

吉永正憲, 三野享史, 竹内理

日本RNA学会年会要旨集, 19th, 2017
Regnase-1は翻訳に依存して炎症関連mRNAを分解する

三野享史, 深尾亜喜良, 藤原俊伸, 竹内理

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo

Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto

CYTOKINE, 63(3) 284-284, Sep, 2013

Professional Memberships

Research Projects

Analysis of immune regulatory mechanisms mediated by mRNA metabolism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2023
Study of mRNA translation in immune system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Mino Takahsi
Study of UPF1-mediated mRNA regulation in immune system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MINO Takashi, TAKEUCHI Osamu
Analysis of posttranscriptional mechanisms of Regnase-1-mediated mRNA decay in innate immune system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

MINO Takashi

Industrial Property Rights

特開2019-073466 IMMUNOSTIMULANTS

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Professional Memberships

Research Projects

Industrial Property Rights

Menu

Coauthors