2005年10月
Natural killer cells in breast cancer cell growth and metastasis in SCID mice
BIOMEDICINE & PHARMACOTHERAPY
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- 巻
- 59
- 号
- SUPPL. 2
- 開始ページ
- S375
- 終了ページ
- S379
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0753-3322(05)80082-4
- 出版者・発行元
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Natural killer (NK) cell is an important component of the innate immune system and plays a central role in host defense against tumor and virus-infected cells. This review briefly summarizes the role of murine NK cells in tumor growth and metastasis of breast cancer cells in severe combined immunodeficiency (SCID) mice. Conventional SCID and NOD-SCID strains have been used to study for xenotransplantion of human tumors. SCID mice models of cancer mimic human diseases and have provided valuable information. However, these mice strains have some residual immunity such as NK cells that somewhat limit post-transplantation growth and metastasis of human xenografts. In contrast, NOD/SCID/gamma c(null) (NOG) mice without common gamma-chain inoculated with breast cancer cells were most efficient in the formation of a large tumor and metastasis. NOG mouse strain without NK activity appears to be more promising as tool for xenotransplantion of human cancer. This new xenotransplant model is relevant and can be recommended for use in clarifying the mechanism of growth of cancer cells as well as for developing new therapeutic strategies against cancer. (c) 2005 Elsevier SAS. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0753-3322(05)80082-4
- ISSN : 0753-3322
- eISSN : 1950-6007
- Web of Science ID : WOS:000234423600043