論文

査読有り
2012年5月

Invariant natural killer T cells infiltrate intestinal allografts undergoing acute cellular rejection

TRANSPLANT INTERNATIONAL
  • Tatsuaki Tsuruyama
  • ,
  • Yasuhiro Fujimoto
  • ,
  • Yukihide Yonekawa
  • ,
  • Masashi Miyao
  • ,
  • Hisashi Onodera
  • ,
  • Shinji Uemoto
  • ,
  • Hironori Haga

25
5
開始ページ
537
終了ページ
544
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1432-2277.2012.01450.x
出版者・発行元
WILEY-BLACKWELL

Immunological responses in human intestinal allografts are poorly understood and accurate diagnosis of acute cellular rejection remains difficult. Here, human intestinal allografts were analyzed by multi-color quantitative fluorescent immunohistochemical morphometry in order to monitor the clinical course of rejection. Morphometry gave two-dimensional plots based on size and circularity, and identified phenotypes of individual cells infiltrating the allograft by fluorescent staining. Using this method, invariant TCRVa24+ NKT (iNKT) cells were observed in the intestinal allograft during rejection. Because these were not identified in the normal donor intestine before surgery, this finding was considered to be a signature of acute cellular rejection of the intestinal allograft. Infiltrating iNKT cells released IL-4 and IL-5, Th2-related cytokines that antagonize the Th1 responses that induce acute cellular rejection. Histological observation suggested eosinophilic enteritis in the mucosa with elevation of IL-4 and IL-5. In conclusion, iNKT cells were recruited to the intestine; however, because higher levels of IL-4 and IL-5 may contribute to eosinophilic enteritis, timely steroid administration is recommended for allograft injury due to enteritis, as well as acute cellular rejection.

リンク情報
DOI
https://doi.org/10.1111/j.1432-2277.2012.01450.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22380521
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000302475700010&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1432-2277.2012.01450.x
  • ISSN : 0934-0874
  • PubMed ID : 22380521
  • Web of Science ID : WOS:000302475700010

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