2012年5月
Invariant natural killer T cells infiltrate intestinal allografts undergoing acute cellular rejection
TRANSPLANT INTERNATIONAL
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- 巻
- 25
- 号
- 5
- 開始ページ
- 537
- 終了ページ
- 544
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1432-2277.2012.01450.x
- 出版者・発行元
- WILEY-BLACKWELL
Immunological responses in human intestinal allografts are poorly understood and accurate diagnosis of acute cellular rejection remains difficult. Here, human intestinal allografts were analyzed by multi-color quantitative fluorescent immunohistochemical morphometry in order to monitor the clinical course of rejection. Morphometry gave two-dimensional plots based on size and circularity, and identified phenotypes of individual cells infiltrating the allograft by fluorescent staining. Using this method, invariant TCRVa24+ NKT (iNKT) cells were observed in the intestinal allograft during rejection. Because these were not identified in the normal donor intestine before surgery, this finding was considered to be a signature of acute cellular rejection of the intestinal allograft. Infiltrating iNKT cells released IL-4 and IL-5, Th2-related cytokines that antagonize the Th1 responses that induce acute cellular rejection. Histological observation suggested eosinophilic enteritis in the mucosa with elevation of IL-4 and IL-5. In conclusion, iNKT cells were recruited to the intestine; however, because higher levels of IL-4 and IL-5 may contribute to eosinophilic enteritis, timely steroid administration is recommended for allograft injury due to enteritis, as well as acute cellular rejection.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1432-2277.2012.01450.x
- ISSN : 0934-0874
- PubMed ID : 22380521
- Web of Science ID : WOS:000302475700010