論文

査読有り
2007年9月

Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: A diffusion tensor imaging study

SCHIZOPHRENIA RESEARCH
  • Hironobu Fujiwara
  • ,
  • Chihiro Namiki
  • ,
  • Kazuyuki Hirao
  • ,
  • Jun Miyata
  • ,
  • Mitsuaki Shimizu
  • ,
  • Hidenao Fukuyama
  • ,
  • Nobukatsu Sawamoto
  • ,
  • Takuji Hayashi
  • ,
  • Toshiya Murai

95
1-3
開始ページ
215
終了ページ
222
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.schres.2007.05.044
出版者・発行元
ELSEVIER SCIENCE BV

Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus may play a role in the pathophysiology of schizophrenia. The cingulum bundles (CBs; posterior and anterior) are the most prominent white matter tracts in the limbic system, furnishing both input and output to the cingulate gyrus. In previous diffusion tensor imaging (DTI) studies, abnormal integrity has been demonstrated in the anterior CB portion, but not the posterior, in schizophrenia. As well, the relationships between the abnormalities of CB integrity and the psychopathology of schizophrenia remain to be elucidated. Using DTI acquired on a 3 T MRI machine, we examined fractional anisotropy (FA) in the anterior and posterior CBs of 42 patients with schizophrenia and 24 group-matched controls. Moreover, we investigated the relationships between CB abnormalities and the psychopathology of schizophrenia. Bilaterally reduced FA was demonstrated in both anterior and posterior CBs in schizophrenia patients. However, the pattern of FA reduction was different between anterior and posterior CBs: the reduction in FA was leftaccentuated in anterior CBs, while no such lateralized abnormality was found in posterior ones. Finally, FA in posterior CBs correlated with positive symptom scores in patients with schizophrenia. These findings suggest that CB abnormalities in schizophrenia are not restricted to the anterior CB, but include the posterior as well. Pathology in the posterior CB would be one of the possible neural underpinnings of positive symptoms in schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.schres.2007.05.044
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17664062
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000249836900028&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.schres.2007.05.044
  • ISSN : 0920-9964
  • PubMed ID : 17664062
  • Web of Science ID : WOS:000249836900028

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