2010年2月
Investigating association of brain volumes with intracranial capacity in schizophrenia
NEUROIMAGE
- 巻
- 49
- 号
- 3
- 開始ページ
- 2503
- 終了ページ
- 2508
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuroimage.2009.09.006
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Intracranial Volume (ICV) is usually treated as a global or nuisance covariate ill almost all volumetric Studies of schizophrenia However, validation for this analytic method has seldom been accomplished In this study. we aimed to determine the effects of ICV oil gray matter (GM) and white matter (WM) volumes Sixty-three patients with schizophrenia and sixty normal controls were recruited, and high resolution TI weighted images were obtained by 3T-MRI After segmentation and normalization of the images into GM, WM, and cerebrospinal fluid (CSF). multiple regression analyses of global CM and WM Volumes were performed using explanatory variables Such as diagnosis, ICV and diagnosis-ICV interaction In addition, associations between regional GM and WM Volumes with ICV were also investigated using voxel-based morphometry (VBM) No significant interaction between diagnosis and ICV was found For global GM volume, whereas interactions were detected in restricted CM areas using VBM Oil the other hand, ail interaction between ICV and diagnosis was found in WM not only for regional volumes, but also for global WM volume The regression slope of global WM Volumes against ICV was steeper in patients with schizophrenia than in healthy controls These results imply that ICV should be carefully evaluated in the analyses Of volumetric studies of schizophrenia, especially when analyzing WM Volumes. (C) 2009 Elsevier Inc All rights reserved
- リンク情報
- ID情報
-
- DOI : 10.1016/j.neuroimage.2009.09.006
- ISSN : 1053-8119
- PubMed ID : 19770046
- Web of Science ID : WOS:000273626400052