論文

査読有り
2010年2月

Investigating association of brain volumes with intracranial capacity in schizophrenia

NEUROIMAGE
  • Keita Ueda
  • Hironobu Fujiwara
  • Jun Miyata
  • Kazuyuki Hirao
  • Teruyasu Saze
  • Ryosaku Kawada
  • Shinsuke Fujimoto
  • Yusuke Tanaka
  • Nobukatsu Sawamoto
  • Hidenao Fukuyama
  • Toshiya Murai
  • 全て表示

49
3
開始ページ
2503
終了ページ
2508
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuroimage.2009.09.006
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Intracranial Volume (ICV) is usually treated as a global or nuisance covariate ill almost all volumetric Studies of schizophrenia However, validation for this analytic method has seldom been accomplished In this study. we aimed to determine the effects of ICV oil gray matter (GM) and white matter (WM) volumes Sixty-three patients with schizophrenia and sixty normal controls were recruited, and high resolution TI weighted images were obtained by 3T-MRI After segmentation and normalization of the images into GM, WM, and cerebrospinal fluid (CSF). multiple regression analyses of global CM and WM Volumes were performed using explanatory variables Such as diagnosis, ICV and diagnosis-ICV interaction In addition, associations between regional GM and WM Volumes with ICV were also investigated using voxel-based morphometry (VBM) No significant interaction between diagnosis and ICV was found For global GM volume, whereas interactions were detected in restricted CM areas using VBM Oil the other hand, ail interaction between ICV and diagnosis was found in WM not only for regional volumes, but also for global WM volume The regression slope of global WM Volumes against ICV was steeper in patients with schizophrenia than in healthy controls These results imply that ICV should be carefully evaluated in the analyses Of volumetric studies of schizophrenia, especially when analyzing WM Volumes. (C) 2009 Elsevier Inc All rights reserved

リンク情報
DOI
https://doi.org/10.1016/j.neuroimage.2009.09.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19770046
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000273626400052&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neuroimage.2009.09.006
  • ISSN : 1053-8119
  • PubMed ID : 19770046
  • Web of Science ID : WOS:000273626400052

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