2007年7月
Attenuated aerobic exercise capacity in CD36 deficiency.
Journal of medical genetics
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- 巻
- 44
- 号
- 7
- 開始ページ
- 445
- 終了ページ
- 7
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1136/jmg.2007.050070
- 出版者・発行元
- B M J PUBLISHING GROUP
BACKGROUND: An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency. METHODS: We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer. RESULTS: In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate. CONCLUSION: This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.
- リンク情報
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- DOI
- https://doi.org/10.1136/jmg.2007.050070
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17412877
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598008
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000247649400005&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1136/jmg.2007.050070
- ISSN : 0022-2593
- eISSN : 1468-6244
- PubMed ID : 17412877
- PubMed Central 記事ID : PMC2598008
- Web of Science ID : WOS:000247649400005