論文

査読有り 国際誌
2007年7月

Attenuated aerobic exercise capacity in CD36 deficiency.

Journal of medical genetics
  • Hidekatsu Yanai
  • ,
  • Ichiro Watanabe
  • ,
  • Kojiro Ishii
  • ,
  • Mie Morimoto
  • ,
  • Hironobu Fujiwara
  • ,
  • Shigeru Yoshida
  • ,
  • Shu-Ping Hui
  • ,
  • Kazuhiko Matsuno
  • ,
  • Hitoshi Chiba

44
7
開始ページ
445
終了ページ
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1136/jmg.2007.050070
出版者・発行元
B M J PUBLISHING GROUP

BACKGROUND: An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency. METHODS: We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer. RESULTS: In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate. CONCLUSION: This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.

リンク情報
DOI
https://doi.org/10.1136/jmg.2007.050070
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17412877
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598008
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000247649400005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1136/jmg.2007.050070
  • ISSN : 0022-2593
  • eISSN : 1468-6244
  • PubMed ID : 17412877
  • PubMed Central 記事ID : PMC2598008
  • Web of Science ID : WOS:000247649400005

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