2017年8月1日
Both low and high serum ferritin levels predict mortality risk in hemodialysis patients without inflammation
Clinical and Experimental Nephrology
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- 巻
- 21
- 号
- 4
- 開始ページ
- 685
- 終了ページ
- 693
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s10157-016-1317-1
- 出版者・発行元
- SPRINGER
Background Serum ferritin concentration >100 ng/mL was associated with a higher risk of death in hemodialysis patients in Japan, whereas such an association was less clear in hemodialysis patients in Western countries. Since Japanese dialysis patients are generally less inflamed than those in Western countries, inflammation may modify the association between serum ferritin and the adverse outcomes.Methods We performed an observational cohort study using data from 2606 Japanese hemodialysis patients who participated in the Dialysis Outcomes and Practice Patterns Study (DOPPS) III (2005-2008) or DOPPS IV (2009-2012). The predictor was serum ferritin category (<50, 50-99.9, 100-199.9, and C200 ng/mL), and the primary and secondary outcomes were all-cause mortality and cardiovascular hospitalization, respectively. C-reactive protein (CRP, cut-off by 0.3 mg/dL) and serum albumin (cut-off by 3.8 g/dL) were stratification factors related to systemic inflammation.Results After adjustment for relevant confounding factors, a U-shaped association was observed between serum ferritin and all-cause mortality in the group with low CRP levels, whereas such relationship was not significant in the high CRP counterparts. In contrast, we found a linear association between serum ferritin and cardiovascular hospitalization in the low CRP and high CRP groups commonly. Similar results were obtained when the total cohort was stratified by serum albumin.Conclusions Serum ferritin showed different patterns of association with all-cause mortality in hemodialysis patients with versus without inflammation, whereas its association with cardiovascular hospitalization was similar regardless of inflammatory conditions.
- リンク情報
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- DOI
- https://doi.org/10.1007/s10157-016-1317-1
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201702221002325889
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27503345
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517589
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406035600018&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84981287647&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84981287647&origin=inward
- ID情報
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- DOI : 10.1007/s10157-016-1317-1
- ISSN : 1342-1751
- eISSN : 1437-7799
- J-Global ID : 201702221002325889
- PubMed ID : 27503345
- PubMed Central 記事ID : PMC5517589
- SCOPUS ID : 84981287647
- Web of Science ID : WOS:000406035600018