2013年1月
Major T Cell Response to a Mycolyl Glycolipid Is Mediated by CD1c Molecules in Rhesus Macaques
INFECTION AND IMMUNITY
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- 巻
- 81
- 号
- 1
- 開始ページ
- 311
- 終了ページ
- 316
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/IAI.00871-12
- 出版者・発行元
- AMER SOC MICROBIOLOGY
Human CD1b molecules contain a maze of hydrophobic pockets and a tunnel capable of accommodating the unusually long, branched acyl chain of mycolic acids, an essential fatty acid component of the cell wall of mycobacteria. It has been accepted that CD1b-bound mycolic acids constitute a scaffold for mycolate-containing (glyco) lipids stimulating CD1b-restricted T cells. Remarkable homology in amino acid sequence is observed between human and monkey CD1b molecules, and indeed, monkey CD1b molecules are able to bind glucose monomycolate (GMM), a glucosylated species of mycolic acids, and present it to specific human T cells in vitro. Nevertheless, we found, unexpectedly, that Mycobacterium bovis bacillus Calmette-Guerin (BCG)-vaccinated monkeys exhibited GMM-specific T cell responses that were restricted by CD1c rather than CD1b molecules. GMM-specific, CD1c-restricted T cells were detected in the circulation of all 4 rhesus macaque monkeys tested after but not before vaccination with BCG. The circulating GMM-specific T cells were detected broadly in both CD4(+) and CD8(+) cell populations, and upon antigenic stimulation, a majority of the GMM-specific T cells produced both gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha), two major host protective cytokines functioning against infection with mycobacteria. Furthermore, the GMM-specific T cells were able to extravasate and approach the site of infection where CD1c(+) cells accumulated. These observations indicate a previously inconceivable role for primate CD1c molecules in eliciting T cell responses to mycolate-containing antigens.
- リンク情報
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- DOI
- https://doi.org/10.1128/IAI.00871-12
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201302229577664333
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/23132493
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000316298000032&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1128/IAI.00871-12
- ISSN : 0019-9567
- eISSN : 1098-5522
- J-Global ID : 201302229577664333
- PubMed ID : 23132493
- Web of Science ID : WOS:000316298000032